EBSCO Logo
Connecting you to content on EBSCOhost
Results
Title

Boron Neutron Capture Therapy: Current Status and Challenges.

Authors

Wang, Song; Zhang, Zhengchao; Miao, Lele; Li, Yumin

Abstract

Boron neutron capture therapy (BNCT) is a re-emerging therapy with the ability to selectively kill tumor cells. After the boron delivery agents enter the tumor tissue and enrich the tumor cells, the thermal neutrons trigger the fission of the boron atoms, leading to the release of boron atoms and then leading to the release of the α particles (4He) and recoil lithium particles (7Li), along with the production of large amounts of energy in the narrow region. With the advantages of targeted therapy and low toxicity, BNCT has become a unique method in the field of radiotherapy. Since the beginning of the last century, BNCT has been emerging worldwide and gradually developed into a technology for the treatment of glioblastoma multiforme, head and neck cancer, malignant melanoma, and other cancers. At present, how to develop and innovate more efficient boron delivery agents and establish a more accurate boron-dose measurement system have become the problem faced by the development of BNCT. We discuss the use of boron delivery agents over the past several decades and the corresponding clinical trials and preclinical outcomes. Furthermore, the discussion brings recommendations on the future of boron delivery agents and this therapy.

Subjects

BORON-neutron capture therapy; THERMAL neutrons; GLIOBLASTOMA multiforme

Publication

Frontiers in Oncology, 2022, Vol 12, p1

ISSN

2234-943X

Publication type

Academic Journal

DOI

10.3389/fonc.2022.788770

EBSCO Connect | Privacy policy | Terms of use | Copyright | Manage my cookies
Journals | Subjects | Sitemap
© 2025 EBSCO Industries, Inc. All rights reserved