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Title

The Molecular Basis and Therapeutic Aspects of Cisplatin Resistance in Oral Squamous Cell Carcinoma.

Authors

Cheng, Yali; Li, Shaoming; Gao, Ling; Zhi, Keqian; Ren, Wenhao

Abstract

Oral squamous cell carcinoma (OSCC) is a kind of malignant tumors with low survival rate and prone to have early metastasis and recurrence. Cisplatin is an alkylating agent which induces DNA damage through the formation of cisplatin-DNA adducts, leading to cell cycle arrest and apoptosis. In the management of advanced OSCC, cisplatin-based chemotherapy or chemoradiotherapy has been considered as the first-line treatment. Unfortunately, only a portion of OSCC patients can benefit from cisplatin treatment, both inherent resistance and acquired resistance greatly limit the efficacy of cisplatin and even cause treatment failure. Herein, this review outline the underlying mechanisms of cisplatin resistance in OSCC from the aspects of DNA damage and repair, epigenetic regulation, transport processes, programmed cell death and tumor microenvironment. In addition, this review summarizes the strategies applicable to overcome cisplatin resistance, which can provide new ideas to improve the clinical therapeutic outcome of OSCC.

Subjects

SQUAMOUS cell carcinoma; CISPLATIN; ALKYLATING agents; SURVIVAL rate; TREATMENT failure; OTOTOXICITY

Publication

Frontiers in Oncology, 2021, Vol 11, p1

ISSN

2234-943X

Publication type

Academic Journal

DOI

10.3389/fonc.2021.761379

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