Title: Oncolytic Viruses and Cancer, Do You Know the Main Mechanism?
Authors: Kooti, Wesam; Esmaeili Gouvarchin Ghaleh, Hadi; Farzanehpour, Mahdieh; Dorostkar, Ruhollah; Jalali Kondori, Bahman; Bolandian, Masoumeh
Abstract: The global rate of cancer has increased in recent years, and cancer is still a threat to human health. Recent developments in cancer treatment have yielded the understanding that viruses have a high potential in cancer treatment. Using oncolytic viruses (OVs) is a promising approach in the treatment of malignant tumors. OVs can achieve their targeted treatment effects through selective cell death and induction of specific antitumor immunity. Targeting tumors and the mechanism for killing cancer cells are among the critical roles of OVs. Therefore, evaluating OVs and understanding their precise mechanisms of action can be beneficial in cancer therapy. This review study aimed to evaluate OVs and the mechanisms of their effects on cancer cells.
Subjects: ONCOGENIC viruses; CANCER treatment; CELL death; CANCER cells; TUMOR treatment
Publication: Frontiers in Oncology, 2021, Vol 11, p1
ISSN: 2234-943X
Publication type: Academic Journal
DOI: 10.3389/fonc.2021.761015

Oncolytic Viruses and Cancer, Do You Know the Main Mechanism?

Kooti, Wesam; Esmaeili Gouvarchin Ghaleh, Hadi; Farzanehpour, Mahdieh; Dorostkar, Ruhollah; Jalali Kondori, Bahman; Bolandian, Masoumeh