Commentary: The Impact of the Time Interval Between Radiation and Hyperthermia on Clinical Outcome in Patients With Locally Advanced Cervical Cancer.

Kroesen, Michiel; Mulder, H. Tim; van Rhoon, Gerard C.; Franckena, Martine

We thank Crezee et al. for their opinion article concerning the impact of the time interval between radiotherapy (RT) and hyperthermia (HT), elicited by our recent publication showing no effect of the time interval on clinical outcome ([1]). We welcome the discussion, as time interval between RT and HT is one of the important issues to solve for the hyperthermia community in the near future. Also, from a patient perspective, receiving a daily radiotherapy fraction nearby and only traveling to a more distant located hyperthermia facility once a week is preferable and could increase acceptance and tolerance of the thermoradiotherapy treatment. First at the clinical level, prospective and uniform measurements and registration on all aspects of hyperthermia treatments, including standardized thermal dose and time interval measurements, should be performed across multiple hyperthermia centers.

CERVICAL cancer; FEVER; RADIATION

Frontiers in Oncology, 2019, Vol 9, p1

2234-943X

Academic Journal

10.3389/fonc.2019.01387