We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Mitochondrial Unfolded Protein Response as a non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond.
- Authors
Kenny, Timothy C.; Manfredi, Giovanni; Germain, Doris
- Abstract
Upon accumulation of misfolded proteins in the mitochondria, the mitochondrial unfolded protein response (UPRmt) is activated. This review focuses on the role of this response in cancer. We discuss evidence that during transformation, the UPRmt may play an essential role in the maintenance of the integrity of the mitochondria in the face of increased oxidative stress. However, the role of the UPRmt in other diseases is also emerging and is therefore also briefly discussed.
- Subjects
ONCOGENES; OXIDATIVE stress; MITOCHONDRIAL proteins
- Publication
Frontiers in Oncology, 2017, p1
- ISSN
2234-943X
- Publication type
Academic Journal
- DOI
10.3389/fonc.2017.00159