Works matching DE "SECRETASES"

Results: 311

Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and Presenilin.

Published in:

Experimental Brain Research, 2012, v. 217, n. 3/4, p. 331, doi. 10.1007/s00221-011-2952-0

By:

Prox, Johannes;
Rittger, Andrea;
Saftig, Paul

Publication type:

Article

Regulation of alpha-secretase ADAM10 expression and activity.

Published in:

Experimental Brain Research, 2012, v. 217, n. 3/4, p. 343, doi. 10.1007/s00221-011-2885-7

By:

Endres, Kristina;
Fahrenholz, Falk

Publication type:

Article

Advances in the cell biology of the trafficking and processing of amyloid precursor protein: impact of familial Alzheimer’s disease mutations.

Published in:

Biochemical Journal, 2024, v. 481, n. 19, p. 1297, doi. 10.1042/BCJ20240056

By:

Jingqi Wang;
Fourriere, Lou;
Gleeson, Paul A.

Publication type:

Article

Delta Secretase and BDNF Signalling in Alzheimer's Disease.

Published in:

Experimed, 2023, v. 13, n. 1, p. 1, doi. 10.26650/experimed.1231893

By:

Unlu, Buse;
Ildiz, Sumeyra;
Ak, Duygu Gezen;
Dursun, Erdinc

Publication type:

Article

The role of ATP‐binding cassette transporter G1 (ABCG1) in Alzheimer's disease: A review of the mechanisms.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2024, v. 134, n. 4, p. 423, doi. 10.1111/bcpt.13981

By:

Yazdi, Mohsen Karbasi;
Alavi, Mohaddeseh Sadat;
Roohbakhsh, Ali

Publication type:

Article

[3H]-L685,458 Binding Sites are Abundant in Multiple Peripheral Organs in Rats: Implications for Safety Assessment of Putative γ-Secretase Targeting Drugs.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2014, v. 115, n. 6, p. 518, doi. 10.1111/bcpt.12271

By:

Yang, Zhi‐Ying;
Li, Jian‐Ming;
Xiao, Ling;
Mou, Lin;
Cai, Yan;
Huang, He;
Luo, Xue‐Gang;
Yan, Xiao‐Xin

Publication type:

Article

The Effect of Genistein on the Content and Activity of α- and β-Secretase and Protein Kinase C in Aβ-Injured Hippocampal Neurons.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2013, v. 112, n. 3, p. 182, doi. 10.1111/bcpt.12009

By:

Liao, Weiliang;
Jin, Guifang;
Zhao, Meishun;
Yang, Hong

Publication type:

Article

The function of Notch1 intracellular domain in the differentiation of gastric cancer.

Published in:

Oncology Letters, 2018, v. 15, n. 5, p. 6171, doi. 10.3892/ol.2018.8118

By:

Hu, Sunkuan;
Chen, Qiuxiang;
Lin, Tiesu;
Hong, Wandong;
Wu, Wenzhi;
Wu, Ming;
Du, Xiaojing;
Jin, Rong

Publication type:

Article

Inhibition of γ-secretase induces G2/M arrest and triggers apoptosis in renal cell carcinoma.

Published in:

Oncology Letters, 2014, v. 8, n. 1, p. 55, doi. 10.3892/ol.2014.2078

By:

KERONG WU;
LI ZHANG;
YIWEI LIN;
KAI YANG;
YUE CHENG

Publication type:

Article

Immunohistochemical characterization of γ-secretase activating protein expression in Alzheimer's disease brains.

Published in:

Neuropathology & Applied Neurobiology, 2012, v. 38, n. 2, p. 132, doi. 10.1111/j.1365-2990.2011.01206.x

By:

Satoh, J.;
Tabunoki, H.;
Ishida, T.;
Saito, Y.;
Arima, K.

Publication type:

Article

Gamma-secretase subunits associate in intracellular membrane compartments in Arabidopsis thaliana.

Published in:

Journal of Experimental Botany, 2014, v. 65, n. 12, p. 1, doi. 10.1093/jxb/eru147

By:

Smolarkiewicz, Michalina;
Skrzypczak, Tomasz;
Michalak, Michał;
Leśniewicz, Krzysztof;
Walker, J. Ross;
Ingram, Gwyneth;
Wojtaszek, Przemysław

Publication type:

Article

BACE1 Inhibition Using 2'-OMePS Steric Blocking Antisense Oligonucleotides.

Published in:

Genes, 2019, v. 10, n. 9, p. 705, doi. 10.3390/genes10090705

By:

Chakravarthy, Madhuri;
Veedu, Rakesh N

Publication type:

Article

Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons.

Published in:

Molecular Brain, 2015, v. 8, p. 1, doi. 10.1186/s13041-015-0163-5

By:

Naomi Mamada;
Daisuke Tanokashira;
Ai Hosaka;
Fuyuki Kametani;
Akira Tamaoka;
Wataru Araki

Publication type:

Article

Cigarette smoke extracts and cadmium induce COX-2 expression through γ-secretase-mediated p38 MAPK activation in C6 astroglia cells.

Published in:

PLoS ONE, 2019, v. 14, n. 2, p. 1, doi. 10.1371/journal.pone.0212749

By:

Lim, Hyun Joung;
Park, Jung Hyun;
Jo, Chulman;
Yoon, Keejung;
Koh, Young Ho

Publication type:

Article

Gamma secretase dependent release of the CD44 cytoplasmic tail upregulates IFI16 in cd44-/- tumor cells, MEFs and macrophages.

Published in:

PLoS ONE, 2018, v. 13, n. 12, p. 1, doi. 10.1371/journal.pone.0207358

By:

Schultz, Kristin;
Grieger (Lindner), Christina;
Li, Yong;
Urbánek, Pavel;
Ruschel, Anne;
Minnich, Kerstin;
Bruder, Dunja;
Gereke, Marcus;
Sechi, Antonio;
Herrlich, Peter

Publication type:

Article

Dissecting conformational changes in APP’s transmembrane domain linked to ε-efficiency in familial Alzheimer’s disease.

Published in:

PLoS ONE, 2018, v. 13, n. 7, p. 1, doi. 10.1371/journal.pone.0200077

By:

Götz, Alexander;
Scharnagl, Christina

Publication type:

Article

APP-BACE1 Interaction and Intracellular Localization Regulate Aβ Production in iPSC-Derived Cortical Neurons.

Published in:

Cellular & Molecular Neurobiology, 2023, v. 43, n. 7, p. 3653, doi. 10.1007/s10571-023-01374-0

By:

Roselli, Sandra;
Satir, Tugce Munise;
Camacho, Rafael;
Fruhwürth, Stefanie;
Bergström, Petra;
Zetterberg, Henrik;
Agholme, Lotta

Publication type:

Article

The Molecular Mechanisms of Action of Photobiomodulation Against Neurodegenerative Diseases: A Systematic Review.

Published in:

Cellular & Molecular Neurobiology, 2022, v. 42, n. 4, p. 955, doi. 10.1007/s10571-020-01016-9

By:

Bathini, Mayukha;
Raghushaker, Chandavalli Ramappa;
Mahato, Krishna Kishore

Publication type:

Article

The Distinct Role of ADAM17 in APP Proteolysis and Microglial Activation Related to Alzheimer's Disease.

Published in:

Cellular & Molecular Neurobiology, 2016, v. 36, n. 4, p. 471, doi. 10.1007/s10571-015-0232-4

By:

Qian, Meng;
Shen, Xiaoqiang;
Wang, Huanhuan

Publication type:

Article

In vitro streptozotocin model for modeling Alzheimer-like changes: effect on amyloid precursor protein secretases and glycogen synthase kinase-3.

Published in:

Journal of Neural Transmission, 2015, v. 122, n. 4, p. 551, doi. 10.1007/s00702-014-1319-7

By:

Plaschke, Konstanze;
Kopitz, Jürgen

Publication type:

Article

Calsenilin Contributes to Neuronal Cell Death in Ischemic Stroke.

Published in:

Brain Pathology, 2013, v. 23, n. 4, p. 402, doi. 10.1111/bpa.12013

By:

Park, Jong‐Sung;
Manzanero, Silvia;
Chang, Jae‐Woong;
Choi, Yuri;
Baik, Sang‐Ha;
Cheng, Yi‐Lin;
Li, Yu‐I;
Gwon, A‐Ryeong;
Woo, Ha‐Na;
Jang, Jiyeon;
Choi, In‐Young;
Lee, Joo‐Yong;
Jung, Yong‐Keun;
Tang, Sung‐Chun;
Sobey, Christopher G.;
Arumugam, Thiruma V.;
Jo, Dong‐Gyu

Publication type:

Article

Involvement of the γ-Secretase-Mediated EphA4 Signaling Pathway in Synaptic Pathogenesis of Alzheimer's Disease.

Published in:

Brain Pathology, 2012, v. 22, n. 6, p. 776, doi. 10.1111/j.1750-3639.2012.00587.x

By:

Matsui, Chiyuki;
Inoue, Eiji;
Kakita, Akiyoshi;
Arita, Kohei;
Deguchi-Tawarada, Maki;
Togawa, Aki;
Yamada, Akio;
Takai, Yoshimi;
Takahashi, Hitoshi

Publication type:

Article

PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases.

Published in:

Nature Medicine, 2013, v. 19, n. 9, p. 1124, doi. 10.1038/nm.3302

By:

Pietri, Mathéa;
Dakowski, Caroline;
Hannaoui, Samia;
Alleaume-Butaux, Aurélie;
Hernandez-Rapp, Julia;
Ragagnin, Audrey;
Mouillet-Richard, Sophie;
Haik, Stéphane;
Bailly, Yannick;
Peyrin, Jean-Michel;
Launay, Jean-Marie;
Kellermann, Odile;
Schneider, Benoit

Publication type:

Article

?-arrestin 2 regulates A? generation and ?-secretase activity in Alzheimer's disease.

Published in:

Nature Medicine, 2013, v. 19, n. 1, p. 43, doi. 10.1038/nm.3023

By:

Thathiah, Amantha;
Horré, Katrien;
Snellinx, An;
Vandewyer, Elke;
Huang, Yunhong;
Ciesielska, Marta;
De Kloe, Gerdien;
Munck, Sebastian;
De Strooper, Bart

Publication type:

Article

β-Secretase inhibition by C-methylisoflavones from Abronia nana.

Published in:

Natural Product Research, 2019, v. 33, n. 12, p. 1705, doi. 10.1080/14786419.2018.1431637

By:

Yang, Eun-Ju;
Lee, Taeho;
Song, Kyung-Sik

Publication type:

Article

Embedded in the Membrane: How Lipids Confer Activity and Specificity to Intramembrane Proteases.

Published in:

2018

By:

Paschkowsky, Sandra;
Oestereich, Felix;
Munter, Lisa Marie

Publication type:

journal article

η-Secretase processing of APP inhibits neuronal activity in the hippocampus.

Published in:

Nature, 2015, v. 526, n. 7573, p. 443, doi. 10.1038/nature14864

By:

Willem, Michael;
Tahirovic, Sabina;
Busche, Marc Aurel;
Ovsepian, Saak V.;
Chafai, Magda;
Kootar, Scherazad;
Hornburg, Daniel;
Evans, Lewis D. B.;
Moore, Steven;
Daria, Anna;
Hampel, Heike;
Müller, Veronika;
Giudici, Camilla;
Nuscher, Brigitte;
Wenninger-Weinzierl, Andrea;
Kremmer, Elisabeth;
Heneka, Michael T.;
Thal, Dietmar R.;
Giedraitis, Vilmantas;
Lannfelt, Lars

Publication type:

Article

An atomic structure of human γ-secretase.

Published in:

Nature, 2015, v. 525, n. 7568, p. 212, doi. 10.1038/nature14892

By:

Bai, Xiao-chen;
Yan, Chuangye;
Yang, Guanghui;
Lu, Peilong;
Ma, Dan;
Sun, Linfeng;
Zhou, Rui;
Scheres, Sjors H. W.;
Shi, Yigong

Publication type:

Article

Corrigendum.

Published in:: Experimental Dermatology, 2017, v. 26, n. 5, p. 467, doi. 10.1111/exd.13351
Publication type:: Article

Role of cholesterol in substrate recognition by γ-secretase.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-94618-2

By:

Nierzwicki, Łukasz;
Olewniczak, Michał;
Chodnicki, Paweł;
Czub, Jacek

Publication type:

Article

HSV-1 and Alzheimer's disease: more than a hypothesis.

Published in:

Frontiers in Pharmacology, 2014, v. 5, p. 1, doi. 10.3389/fphar.2014.00097

By:

Piacentini, Roberto;
De Chiara, Giovanna;
Li Puma, Domenica D.;
Ripoli, Cristian;
Marcocci, Maria E.;
Garaci, Enrico;
Palamara, Anna T.;
Grassi, Claudio;
Arancio, Ottavio;
Manservigi, Roberto

Publication type:

Article

Presenilin 1/γ-secretase modulates P-cadherin processing and influences cell adhesion in oral squamous cell carcinoma cell lines.

Published in:

Carcinogenesis, 2013, v. 34, n. 11, p. 2622, doi. 10.1093/carcin/bgt211

By:

Bauer, Karin;
Gosau, Martin;
Reinders, Jörg;
Oefner, Peter;
Reichert, Torsten E.;
Bauer, Richard

Publication type:

Article

The Benzodiazepine-Dementia Disorders Link: Current State of Knowledge.

Published in:

2016

By:

Pariente, Antoine;
Gage, Sophie;
Moore, Nicholas;
Bégaud, Bernard;
de Gage, Sophie Billioti

Publication type:

journal article

Transcriptional and post-transcriptional regulation of β-secretase.

Published in:

IUBMB Life, 2012, v. 64, n. 12, p. 943, doi. 10.1002/iub.1099

By:

Tamagno, Elena;
Guglielmotto, M.;
Monteleone, D.;
Vercelli, A.;
Tabaton, M.

Publication type:

Article

Erratum.

Published in:: 2011
Publication type:: Erratum

The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1).

Published in:

PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0129047

By:

von Einem, Bjoern;
Wahler, Anke;
Schips, Tobias;
Serrano-Pozo, Alberto;
Proepper, Christian;
Boeckers, Tobias M.;
Rueck, Angelika;
Wirth, Thomas;
Hyman, Bradley T.;
Danzer, Karin M.;
Thal, Dietmar R.;
von Arnim, Christine A. F.

Publication type:

Article

The Resveratrol Trimer Miyabenol C Inhibits β-Secretase Activity and β-Amyloid Generation.

Published in:

PLoS ONE, 2015, v. 10, n. 1, p. 1, doi. 10.1371/journal.pone.0115973

By:

Hu, Jin;
Lin, Ting;
Gao, Yuehong;
Xu, Junyue;
Jiang, Chao;
Wang, Guanghui;
Bu, Guojun;
Xu, Huaxi;
Chen, Haifeng;
Zhang, Yun-wu

Publication type:

Article

Independent Relationship between Amyloid Precursor Protein (APP) Dimerization and γ-Secretase Processivity.

Published in:

PLoS ONE, 2014, v. 9, n. 10, p. 1, doi. 10.1371/journal.pone.0111553

By:

Jung, Joo In;
Premraj, Sasha;
Cruz, Pedro E.;
Ladd, Thomas B.;
Kwak, Yewon;
Koo, Edward H.;
Felsenstein, Kevin M.;
Golde, Todd E.;
Ran, Yong

Publication type:

Article

High Resolution Imaging Study of Interactions between the 37 kDa/67 kDa Laminin Receptor and APP, Beta-Secretase and Gamma-Secretase in Alzheimer's Disease.

Published in:

PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0100373

By:

Jovanovic, Katarina;
Loos, Ben;
Da Costa Dias, Bianca;
Penny, Clement;
Weiss, Stefan F. T.

Publication type:

Article

Efavirenz Promotes β-Secretase Expression and Increased Aβ1-40,42 via Oxidative Stress and Reduced Microglial Phagocytosis: Implications for HIV Associated Neurocognitive Disorders (HAND).

Published in:

PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0095500

By:

Brown, Lecia A. M.;
Jin, Jingji;
Ferrell, Darren;
Sadic, Edin;
Obregon, Demian;
Smith, Adam J.;
Tan, Jun;
Giunta, Brian

Publication type:

Article

Increased γ-Secretase Activity in Idiopathic Normal Pressure Hydrocephalus Patients with β-Amyloid Pathology.

Published in:

PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0093717

By:

Laiterä, Tiina;
Sarajärvi, Timo;
Haapasalo, Annakaisa;
Puli, Lakshman;
Kauppinen, Tarja;
Mäkinen, Petra;
Rauramaa, Tuomas;
Tanila, Heikki;
Jääskeläinen, Juha E.;
Alafuzoff, Irina;
Soininen, Hilkka;
Leinonen, Ville;
Hiltunen, Mikko

Publication type:

Article

Postsynaptic Target Specific Synaptic Dysfunctions in the CA3 Area of BACE1 Knockout Mice.

Published in:

PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0092279

By:

Wang, Hui;
Megill, Andrea;
Wong, Philip C.;
Kirkwood, Alfredo;
Lee, Hey-Kyoung

Publication type:

Article

Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors.

Published in:

PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0084547

By:

Sproul, Andrew A.;
Jacob, Samson;
Pre, Deborah;
Kim, Soong Ho;
Nestor, Michael W.;
Navarro-Sobrino, Miriam;
Santa-Maria, Ismael;
Zimmer, Matthew;
Aubry, Soline;
Steele, John W.;
Kahler, David J.;
Dranovsky, Alex;
Arancio, Ottavio;
Crary, John F.;
Gandy, Sam;
Noggle, Scott A.

Publication type:

Article

The MEK/ERK Pathway Promotes NOTCH Signalling in Pancreatic Cancer Cells.

Published in:

PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0085502

By:

Tremblay, Isabelle;
Paré, Emanuel;
Arsenault, Dominique;
Douziech, Mélanie;
Boucher, Marie-Josée

Publication type:

Article

Analysis of the Overall Structure of the Multi-Domain Amyloid Precursor Protein (APP).

Published in:

PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0081926

By:

Coburger, Ina;
Dahms, Sven O.;
Roeser, Dirk;
Gührs, Karl-Heinz;
Hortschansky, Peter;
Than, Manuel E.

Publication type:

Article

γ-Secretase Components as Predictors of Breast Cancer Outcome.

Published in:

PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0079249

By:

Peltonen, Hanna M.;
Haapasalo, Annakaisa;
Hiltunen, Mikko;
Kataja, Vesa;
Kosma, Veli-Matti;
Mannermaa, Arto

Publication type:

Article

Suppression of Alzheimer’s Disease-Related Phenotypes by Geranylgeranylacetone in Mice.

Published in:

PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0076306

By:

Hoshino, Tatsuya;
Suzuki, Koichiro;
Matsushima, Takahide;
Yamakawa, Naoki;
Suzuki, Toshiharu;
Mizushima, Tohru

Publication type:

Article

GPR3 Stimulates Aβ Production via Interactions with APP and β-Arrestin2.

Published in:

PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0074680

By:

Nelson, Christopher D.;
Sheng, Morgan

Publication type:

Article

High Glucose Promotes Aβ Production by Inhibiting APP Degradation.

Published in:

PLoS ONE, 2013, v. 8, n. 7, p. 1, doi. 10.1371/journal.pone.0069824

By:

Yang, Yi;
Wu, Yili;
Zhang, Shuting;
Song, Weihong

Publication type:

Article

Turnover of Amyloid Precursor Protein Family Members Determines Their Nuclear Signaling Capability.

Published in:

PLoS ONE, 2013, v. 8, n. 7, p. 1, doi. 10.1371/journal.pone.0069363

By:

Gersbacher, Manuel T.;
Goodger, Zoë V.;
Trutzel, Annette;
Bundschuh, Diana;
Nitsch, Roger M.;
Konietzko, Uwe

Publication type:

Article