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- Title
Regulation of microglial responses after pediatric traumatic brain injury: exploring the role of SHIP-1.
- Authors
Chu, Erskine; Mychasiuk, Richelle; Green, Tabitha R F; Zamani, Akram; Dill, Larissa K; Sharma, Rishabh; Raftery, April L; Tsantikos, Evelyn; Hibbs, Margaret L; Semple, Bridgette D
- Abstract
Severe traumatic brain injury (TBI) is the world's leading cause of permanent neurological disability in children. TBI-induced neurological deficits may be driven by neuroinflammation post-injury. Abnormal activity of SH2 domain-containing inositol 5' phosphatase-1 (SHIP-1) has been associated with dysregulated immunological responses, but the role of SHIP-1 in the brain remains unclear. The current study investigated the immunoregulatory role of SHIP-1 in a mouse model of moderate-severe pediatric TBI.
- Publication
Frontiers in neuroscience, 2023, Vol 17, p1276495
- ISSN
1662-4548
- Publication type
Journal Article
- DOI
10.3389/fnins.2023.1276495