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- Title
Editorial: Inborn Errors of Immunity (IEI) breaking immune homeostasis and tolerance: a key role for T regulatory cells.
- Authors
De Rosa, Veronica; Sogkas, Georgios; Bacchetta, Rosa
- Abstract
The editorial in Frontiers in Immunology discusses Inborn Errors of Immunity (IEI) and their impact on immune homeostasis and tolerance, with a focus on T regulatory cells. IEI are caused by mutations in genes regulating immune processes, leading to susceptibility to infections and immune-related complications. The article highlights the classification of IEI into 9 groups and introduces the concept of Primary Immune Regulatory Disorders (PIRDs) and Tregopathies. It also explores the role of Tregs in various immune disorders and potential therapeutic approaches for IEI.
- Subjects
REGULATORY T cells; REGULATORY B cells; IMMUNOLOGIC memory; IMMUNITY; TRANSCRIPTION factors
- Publication
Frontiers in Immunology, 2025, p1
- ISSN
1664-3224
- Publication type
Academic Journal
- DOI
10.3389/fimmu.2024.1532079