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Title: RETRACTED: Cancer-Associated Fibroblasts-Derived Exosomes Suppress Immune Cell Function in Breast Cancer via the miR-92/PD-L1 Pathway.
Abstract: This article, titled "RETRACTED: Cancer-Associated Fibroblasts-Derived Exosomes Suppress Immune Cell Function in Breast Cancer via the miR-92/PD-L1 Pathway," explores the role of cancer-associated fibroblasts (CAFs) in breast cancer and their ability to suppress immune cell function. The study found that CAF-derived exosomes promote the expression of miR-92 and programmed cell death receptor ligand 1 (PD-L1) in breast cancer cells, leading to the apoptosis of T cells and impaired function of natural killer (NK) cells. The study provides insights into a novel mechanism of immune suppression in the tumor microenvironment. However, it is important to note that this article has been retracted.
Subjects: PROGRAMMED death-ligand 1; PROGRAMMED cell death 1 receptors; POLYACRYLAMIDE gel electrophoresis; GENE expression; LIFE sciences; RENILLA luciferase; CANCER cell growth
Publication: Frontiers in Immunology, 2024, p1
ISSN: 1664-3224
Publication type: Academic Journal
DOI: 10.3389/fimmu.2020.02026

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RETRACTED: Cancer-Associated Fibroblasts-Derived Exosomes Suppress Immune Cell Function in Breast Cancer via the miR-92/PD-L1 Pathway.