Title: Salivary N1-Methyl-2-Pyridone-5-Carboxamide, a Biomarker for Uranium Uptake, in Kuwaiti Children Exhibiting Exceptional Weight Gain.
Authors: Goodson, Jo Max; Hardt, Markus; Hartman, Mor-Li; Alqaderi, Hend; Green, Daniel; Tavares, Mary; Mutawa, Al-Sabiha; Ariga, Jitendra; Soparkar, Pramod; Behbehani, Jawad; Behbehani, Kazem
Abstract: In a longitudinal study of 6,158 Kuwaiti children, we selected 94 for salivary metabolomic analysis who were neither obese (by waist circumference) nor metabolic syndrome (MetS) positive (238U and measured salivary 2PY was highest in the area where military activity was highest. The prevalence pattern of adult diabetes in Kuwait suggests that a transient diabetogenic factor has been introduced into the Kuwaiti population. Although we did not measure uranium in our study, the presence of a salivary biomarker for uranium consumption suggests potential toxicity related to obesity in children.
Subjects: KUWAIT; UNITED States; EXCEPTIONAL children; WEIGHT gain; URANIUM; WAIST circumference; METABOLIC syndrome
Publication: Frontiers in Endocrinology, 2019, pN.PAG
ISSN: 1664-2392
Publication type: Academic Journal
DOI: 10.3389/fendo.2019.00382

Salivary N1-Methyl-2-Pyridone-5-Carboxamide, a Biomarker for Uranium Uptake, in Kuwaiti Children Exhibiting Exceptional Weight Gain.

Goodson, Jo Max; Hardt, Markus; Hartman, Mor-Li; Alqaderi, Hend; Green, Daniel; Tavares, Mary; Mutawa, Al-Sabiha; Ariga, Jitendra; Soparkar, Pramod; Behbehani, Jawad; Behbehani, Kazem