Works matching DE "SECRETASE inhibitors"

Results: 232

Sterubin: Enantioresolution and Configurational Stability, Enantiomeric Purity in Nature, and Neuroprotective Activity in Vitro and in Vivo.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 32, p. 7299, doi. 10.1002/chem.202001264

By:

Hofmann, Julian;
Fayez, Shaimaa;
Scheiner, Matthias;
Hoffmann, Matthias;
Oerter, Sabrina;
Appelt‐Menzel, Antje;
Maher, Pamela;
Maurice, Tangui;
Bringmann, Gerhard;
Decker, Michael

Publication type:

Article

Supramolecular Regulation of Polydopamine Formation by Amyloid Fibers.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 24, p. 5500, doi. 10.1002/chem.202000437

By:

Shin, J. H.;
Le, Nghia T. K.;
Jang, Hongje;
Lee, Taehoon;
Kang, Kyungtae

Publication type:

Article

Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3β Inhibitors.

Published in:

Angewandte Chemie, 2015, v. 127, n. 5, p. 1598, doi. 10.1002/ange.201410456

By:

Prati, Federica;
De Simone, Angela;
Bisignano, Paola;
Armirotti, Andrea;
Summa, Maria;
Pizzirani, Daniela;
Scarpelli, Rita;
Perez, Daniel I.;
Andrisano, Vincenza;
Perez-Castillo, Ana;
Monti, Barbara;
Massenzio, Francesca;
Polito, Letizia;
Racchi, Marco;
Favia, Angelo D.;
Bottegoni, Giovanni;
Martinez, Ana;
Bolognesi, Maria Laura;
Cavalli, Andrea

Publication type:

Article

VEGF combined with DAPT promotes tissue regeneration and remodeling in vascular grafts.

Published in:

Regenerative Biomaterials, 2023, v. 10, p. 1, doi. 10.1093/rb/rbad088

By:

Yang, Tao;
Li, Guangxu;
Li, Xifeng;
Wei, Boyang;
Su, Hengxian;
Liu, Wenchao;
Guo, Shenquan;
Yang, Nan;
Xu, Tao;
Duan, Chuanzhi

Publication type:

Article

[3H]-L685,458 Binding Sites are Abundant in Multiple Peripheral Organs in Rats: Implications for Safety Assessment of Putative γ-Secretase Targeting Drugs.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2014, v. 115, n. 6, p. 518, doi. 10.1111/bcpt.12271

By:

Yang, Zhi‐Ying;
Li, Jian‐Ming;
Xiao, Ling;
Mou, Lin;
Cai, Yan;
Huang, He;
Luo, Xue‐Gang;
Yan, Xiao‐Xin

Publication type:

Article

Impact of Drying Processes on Phenolics and In Vitro Health-Related Activities of Indigenous Plants in Thailand.

Published in:

Plants (2223-7747), 2022, v. 11, n. 3, p. 294, doi. 10.3390/plants11030294

By:

Sirichai, Pandaree;
Kittibunchakul, Suwapat;
Thangsiri, Sirinapa;
On-Nom, Nattira;
Chupeerach, Chaowanee;
Temviriyanukul, Piya;
Inthachat, Woorawee;
Nuchuchua, Onanong;
Aursalung, Amornrat;
Sahasakul, Yuraporn;
Charoenkiatkul, Somsri;
Suttisansanee, Uthaiwan

Publication type:

Article

Inhibition of ཫ-secretase activity synergistically enhances tumour necrosis factor-related apoptosis-inducing ligand induced apoptosis in T-cell acute lymphoblastic leukemia cells via upregulation of death receptor 5.

Published in:

Oncology Letters, 2016, v. 12, n. 4, p. 2900, doi. 10.3892/ol.2016.5011

By:

GREENE, LISA M.;
NATHWANI, SEEMA M.;
ZISTERER, DANIELA M.

Publication type:

Article

Gastric tumor-initiating CD44+ cells and epithelial-mesenchymal transition are inhibited by γ-secretase inhibitor DAPT.

Published in:

Oncology Letters, 2015, v. 10, n. 5, p. 3293, doi. 10.3892/ol.2015.3727

By:

LU-CHUN LI;
DONG-LIN WANG;
YONG-ZHONG WU;
WEI-QI NIAN;
ZHI-JUAN WU;
YAN LI;
HUI-WEN MA;
JIANG-HE SHAO

Publication type:

Article

Gastric cancer cell growth and epithelial-mesenchymal transition are inhibited by γ-secretase inhibitor DAPT.

Published in:

Oncology Letters, 2014, v. 7, n. 6, p. 2160, doi. 10.3892/ol.2014.1980

By:

LU-CHUN LI;
YANG PENG;
YAN-MIM LIU;
LU-LU WANG;
XIAO-LING WU

Publication type:

Article

Experimental and Theoretical Approaches in the Study of Phenanthroline‐Tetrahydroquinolines for Alzheimer's Disease.

Published in:

ChemistryOpen, 2019, v. 8, n. 5, p. 627, doi. 10.1002/open.201900073

By:

Duarte, Yorley;
Gutierrez, Margarita;
Álvarez, Rocío;
Alzate‐Morales, Jans H.;
Soto‐Delgado, Jorge

Publication type:

Article

Acetylcholinesterase Inhibition Activity of Hippeastrum papilio (Ravenna) Van Scheepen (Amaryllidaceae) Using Zebrafish Brain Homogenates.

Published in:

Life (2075-1729), 2023, v. 13, n. 8, p. 1721, doi. 10.3390/life13081721

By:

Tallini, Luciana R.;
da Silva, Camila Rockenbach;
Jung, Tatiana;
Alves, Elen de Oliveira;
Baldin, Samira Leila;
Apel, Miriam;
Timmers, Luis F. S. M.;
Rico, Eduardo Pacheco;
Bastida, Jaume;
Zuanazzi, José Angelo S.

Publication type:

Article

ID 217. In silico Evaluation of Acetylcholinesterase Inhibitory Effect of Selected Flavanones.

Published in:

Journal of Pharmacy & Bioallied Sciences, 2020, v. 12, p. 925

By:

Law Su Hui;
Shukkoor, Mohamed Saleem Abdul

Publication type:

Article

Anthraquinones extracted from Rubia cordifolia Linn as potential ligands to treat Alzheimer's disease.

Published in:

Thai Journal of Pharmaceutical Sciences, 2021, v. 45, n. 3, p. 178

By:

Srinivasulu, Pottella;
Babu, Janga Ramesh;
Kumar, T. N. V. Ganesh;
Kumar, Padarthi Pavan;
Vidyadhara, S.

Publication type:

Article

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.

Published in:

Nature Genetics, 2014, v. 46, n. 4, p. 364, doi. 10.1038/ng.2913

By:

Knoechel, Birgit;
Roderick, Justine E;
Williamson, Kaylyn E;
Zhu, Jiang;
Lohr, Jens G;
Cotton, Matthew J;
Gillespie, Shawn M;
Fernandez, Daniel;
Ku, Manching;
Wang, Hongfang;
Piccioni, Federica;
Silver, Serena J;
Jain, Mohit;
Pearson, Daniel;
Kluk, Michael J;
Ott, Christopher J;
Shultz, Leonard D;
Brehm, Michael A;
Greiner, Dale L;
Gutierrez, Alejandro

Publication type:

Article

Notch signalling pathway as an oncogenic factor involved in cancer development.

Published in:

Contemporary Oncology / Współczesna Onkologia, 2016, v. 20, n. 4, p. 267, doi. 10.5114/wo.2016.61845

By:

Brzozowa-Zasada, Marlena;
Piecuch, Adam;
Dittfeld, Anna;
Mielańczyk, Łukasz;
Michalski, Marek;
Wyrobiec, Grzegorz;
Harabin-Słowińska, Marzena;
Kurek, Józef;
Wojnicz, Romuald

Publication type:

Article

FHL1C induces apoptosis in notch1-dependent T-ALL cells through an interaction with RBP-J.

Published in:

BMC Cancer, 2014, v. 14, p. 1, doi. 10.1186/1471-2407-14-463

By:

Wei Fu;
Kai Wang;
Jun-Long Zhao;
Heng-Chao Yu;
San-Zhong Li;
Yan Lin;
Liang Liang;
Si-Yong Huang;
Ying-Min Liang;
Hua Han;
Hong-Yan Qin

Publication type:

Article

Loss of Notch dimerization perturbs intestinal homeostasis by a mechanism involving HDAC activity.

Published in:

PLoS Genetics, 2024, v. 20, n. 12, p. 1, doi. 10.1371/journal.pgen.1011486

By:

Dai, Quanhui;
Preusse, Kristina;
Yu, Danni;
Kovall, Rhett A.;
Thorner, Konrad;
Lin, Xinhua;
Kopan, Raphael

Publication type:

Article

Metal–Organic Frameworks Harness Cu Chelating and Photooxidation Against Amyloid β Aggregation in Vivo.

Published in:

Chemistry - A European Journal, 2019, v. 25, n. 14, p. 3489, doi. 10.1002/chem.201805835

By:

Yu, Dongqin;
Guan, Yijia;
Bai, Fuquan;
Du, Zhi;
Gao, Nan;
Ren, Jinsong;
Qu, Xiaogang

Publication type:

Article

A Versatile Approach to CF3-Containing 2-Pyrrolidones by Tandem Michael Addition-Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors.

Published in:

2015

By:

Mateu, Natalia;
Ciordia, Myriam;
Delgado, Oscar;
Sánchez ‐ Roselló, María;
Trabanco, Andrés A.;
Van Gool, Michiel;
Tresadern, Gary;
Pérez ‐ Benito, Laura;
Fustero, Santos

Publication type:

Other

Drugs targeting TGF-β/Notch interaction attenuate hypertrophic scar formation by optic atrophy 1-mediated mitochondrial fusion.

Published in:

Molecular & Cellular Biochemistry, 2024, v. 479, n. 11, p. 3049, doi. 10.1007/s11010-023-04912-y

By:

Huo, Da;
Bi, Xin-yu;
Zeng, Jun-ling;
Dai, Da-mao;
Dong, Xiang-lin

Publication type:

Article

Inhibition of Notch signaling facilitates the differentiation of human-induced pluripotent stem cells into neural stem cells.

Published in:

Molecular & Cellular Biochemistry, 2014, v. 395, n. 1/2, p. 291, doi. 10.1007/s11010-014-2130-3

By:

Chen, Chun-Yuan;
Liao, Wei;
Lou, Yuan-Lei;
Li, Qing;
Hu, Bin;
Wang, Yang;
Deng, Zhi-Feng

Publication type:

Article

Synthesis of carbon-14 and stable isotope labeled Avagacestat: a novel gamma secretase inhibitor for the treatment of Alzheimer's disease.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2014, v. 57, n. 10, p. 600, doi. 10.1002/jlcr.3224

By:

Burrell, Richard C.;
Easter, John A.;
Cassidy, Michael P.;
Gillman, Kevin W.;
Olson, Richard E.;
Bonacorsi, Samuel J.

Publication type:

Article

NICD/Hes1 影响心肌梗死后小鼠缺血心肌的血管新生.

Published in:

Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu, 2023, v. 27, n. 23, p. 3635, doi. 10.12307/2023.588

By:

卢鹏飞;
施伟丽

Publication type:

Article

The genetic landscape for amyloid beta fibril nucleation accurately discriminates familial Alzheimer's disease mutations.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.63364

By:

Seuma, Mireia;
Faure, Andre J.;
Badia, Marta;
Lehner, Ben;
Bolognesi, Benedetta

Publication type:

Article

BACE inhibitor treatment of mice induces hyperactivity in a Seizure-related gene 6 family dependent manner without altering learning and memory.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-94369-0

By:

Nash, A.;
Gijsen, H. J. M.;
Hrupka, B. J.;
Teng, K. S.-L.;
Lichtenthaler, S. F.;
Takeshima, H.;
Gunnersen, J. M.;
Munro, K. M.

Publication type:

Article

Top Notch Targeting Strategies in Cancer: A Detailed Overview of Recent Insights and Current Perspectives.

Published in:

Cells (2073-4409), 2020, v. 9, n. 6, p. 1503, doi. 10.3390/cells9061503

By:

Moore, Gillian;
Annett, Stephanie;
McClements, Lana;
Robson, Tracy

Publication type:

Article

The protein–surfactant stoichiometry governs the conformational switching and amyloid nucleation kinetics of tau K18.

Published in:

European Biophysics Journal, 2020, v. 49, n. 6, p. 425, doi. 10.1007/s00249-020-01447-8

By:

Kaur, Jaspreet;
Giri, Anjali;
Bhattacharya, Mily

Publication type:

Article

Maintenance of Mouse Nephron Progenitor Cells in Aggregates with Gamma-Secretase Inhibitor.

Published in:

PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0129242

By:

Yuri, Shunsuke;
Nishikawa, Masaki;
Yanagawa, Naomi;
Jo, Oak D.;
Yanagawa, Norimoto

Publication type:

Article

Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors.

Published in:

PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0128619

By:

Ran, Yong;
Ladd, Gabriela Z.;
Ceballos-Diaz, Carolina;
Jung, Joo In;
Greenbaum, Doron;
Felsenstein, Kevin M.;
Golde, Todd E.

Publication type:

Article

Transcriptional Profiling of Ectoderm Specification to Keratinocyte Fate in Human Embryonic Stem Cells.

Published in:

PLoS ONE, 2015, v. 10, n. 4, p. 1, doi. 10.1371/journal.pone.0122493

By:

Tadeu, Ana Mafalda Baptista;
Lin, Samantha;
Hou, Lin;
Chung, Lisa;
Zhong, Mei;
Zhao, Hongyu;
Horsley, Valerie

Publication type:

Article

A γ-Secretase Inhibitor, but Not a γ-Secretase Modulator, Induced Defects in BDNF Axonal Trafficking and Signaling: Evidence for a Role for APP.

Published in:

PLoS ONE, 2015, v. 10, n. 2, p. 1, doi. 10.1371/journal.pone.0118379

By:

Weissmiller, April M.;
Natera-Naranjo, Orlangie;
Reyna, Sol M.;
Pearn, Matthew L.;
Zhao, Xiaobei;
Nguyen, Phuong;
Cheng, Soan;
Goldstein, Lawrence S. B.;
Tanzi, Rudolph E.;
Wagner, Steven L.;
Mobley, William C.;
Wu, Chengbiao

Publication type:

Article

Evidence of a Novel Mechanism for Partial γ-Secretase Inhibition Induced Paradoxical Increase in Secreted Amyloid β Protein.

Published in:

PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0091531

By:

Barnwell, Eliza;
Padmaraju, Vasudevaraju;
Baranello, Robert;
Pacheco-Quinto, Javier;
Crosson, Craig;
Ablonczy, Zsolt;
Eckman, Elizabeth;
Eckman, Christopher B.;
Ramakrishnan, Viswanathan;
Greig, Nigel H.;
Pappolla, Miguel A.;
Sambamurti, Kumar

Publication type:

Article

Notch γ-Secretase Inhibitor Dibenzazepine Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm in ApoE Knockout Mice by Multiple Mechanisms.

Published in:

PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0083310

By:

Zheng, Yue-Hong;
Li, Fang-Da;
Tian, Cui;
Ren, Hua-Liang;
Du, Jie;
Li, Hui-Hua

Publication type:

Article

Amyloid-β and APP Deficiencies Cause Severe Cerebrovascular Defects: Important Work for an Old Villain.

Published in:

PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0075052

By:

Luna, Salvadore;
Cameron, D. Joshua;
Ethell, Douglas W.

Publication type:

Article

532 nm Low-Power Laser Irradiation Recovers γ-Secretase Inhibitor-Mediated Cell Growth Suppression and Promotes Cell Proliferation via Akt Signaling.

Published in:

PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0070737

By:

Fukuzaki, Yumi;
Sugawara, Haruna;
Yamanoha, Banri;
Kogure, Shinichi

Publication type:

Article

Visualizing Active Enzyme Complexes Using a Photoreactive Inhibitor for Proximity Ligation – Application on γ-Secretase

Published in:

PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0063962

By:

Schedin-Weiss, Sophia;
Inoue, Mitsuhiro;
Teranishi, Yasuhiro;
Yamamoto, Natsuko Goto;
Karlström, Helena;
Winblad, Bengt;
Tjernberg, Lars O.

Publication type:

Article

Prion Protein Is Decreased in Alzheimer's Brain and Inversely Correlates with BACE1 Activity, Amyloid-β Levels and Braak Stage.

Published in:

PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0059554

By:

Whitehouse, Isobel J.;
Miners, J. Scott;
Glennon, Elizabeth B. C.;
Kehoe, Patrick G.;
Love, Seth;
Kellett, Katherine A. B.;
Hooper, Nigel M.

Publication type:

Article

Differential Roles of Hath1, MUC2 and P27Kip1 in Relation with Gamma-Secretase Inhibition in Human Colonic Carcinomas: A Translational Study.

Published in:

PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0055904

By:

Souazé, Frédérique;
Bou-Hanna, Chantal;
Kandel, Christine;
Leclair, François;
Devallière, Julie;
Charreau, Béatrice;
Bézieau, Stéphane;
Mosnier, Jean-François;
Laboisse, Christian L.

Publication type:

Article

Long-Term Treatment of Thalidomide Ameliorates Amyloid-Like Pathology through Inhibition of β-Secretase in a Mouse Model of Alzheimer’s Disease.

Published in:

PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0055091

By:

He, Ping;
Cheng, Xin;
Staufenbiel, Matthias;
Li, Rena;
Shen, Yong

Publication type:

Article

Loss of RBPj in Postnatal Excitatory Neurons Does Not Cause Neurodegeneration or Memory Impairments in Aged Mice.

Published in:

PLoS ONE, 2012, v. 7, n. 10, p. 1, doi. 10.1371/journal.pone.0048180

By:

Sato, Chihiro;
Turkoz, Mustafa;
Dearborn, Joshua T.;
Wozniak, David F.;
Kopan, Raphael;
Hass, Matthew R.

Publication type:

Article

The Novel Gamma Secretase Inhibitor RO4929097 Reduces the Tumor Initiating Potential of Melanoma.

Published in:

PLoS ONE, 2011, v. 6, n. 9, p. 1, doi. 10.1371/journal.pone.0025264

By:

Huynh, Chanh;
Poliseno, Laura;
Segura, Miguel F.;
Medicherla, Ratna;
Haimovic, Adele;
Menendez, Silvia;
Shulian Shang;
Pavlick, Anna;
Yongzhao Shao;
Darvishian, Farbod;
Boylan, John F.;
Osman, Iman;
Hernando, Eva

Publication type:

Article

Iron‐Catalyzed Regioselective Synthesis of 2‐Arylbenzoxazoles and 2‐Arylbenzothiazoles via Alternative Reaction Pathways.

Published in:

European Journal of Organic Chemistry, 2020, v. 2020, n. 19, p. 2819, doi. 10.1002/ejoc.202000014

By:

Henry, Martyn C.;
Abbinante, Vincenzo Mirco;
Sutherland, Andrew

Publication type:

Article

Jean‐Pierre Sauvage: The Lord of the Rings (II).

Published in:

European Journal of Organic Chemistry, 2020, v. 2020, n. 14, p. 2007, doi. 10.1002/ejoc.202000404

By:

Martín, Nazario

Publication type:

Article

Phase 2 study of RO4929097, a gamma-secretase inhibitor, in metastatic melanoma: SWOG 0933.

Published in:

Cancer (0008543X), 2015, v. 121, n. 3, p. 432, doi. 10.1002/cncr.29055

By:

Lee, Sylvia M.;
Moon, James;
Redman, Bruce G.;
Chidiac, Tarek;
Flaherty, Lawrence E.;
Zha, Yuanyuan;
Othus, Megan;
Ribas, Antoni;
Sondak, Vernon K.;
Gajewski, Thomas F.;
Margolin, Kim A.

Publication type:

Article

In Silico Design of Beta-Secretase Inhibitors in Alzheimer's Disease.

Published in:

Chemical Biology & Drug Design, 2015, v. 86, n. 3, p. 284, doi. 10.1111/cbdd.12492

By:

Semighini, Evandro Pizeta

Publication type:

Article

The Discovery of Novel β-Secretase Inhibitors: Pharmacophore Modeling, Virtual Screening, and Docking Studies.

Published in:

Chemical Biology & Drug Design, 2012, v. 79, n. 6, p. 972, doi. 10.1111/j.1747-0285.2012.01367.x

By:

Niu, Yan;
Ma, Chao;
Jin, Hongwei;
Xu, Fengrong;
Gao, Haifei;
Liu, Peng;
Li, Yongjian;
Wang, Chao;
Yang, Guanyu;
Xu, Ping

Publication type:

Article

Dimensionality-reduction techniques for complex mass spectrometric datasets: application to laboratory atmospheric organic oxidation experiments.

Published in:

Atmospheric Chemistry & Physics Discussions, 2019, p. 1, doi. 10.5194/acp-2019-469

By:

Koss, Abigail R.;
Canagaratna, Manjula R.;
Zaytsev, Alexander;
Krechmer, Jordan E.;
Breitenlechner, Martin;
Nihill, Kevin;
Lim, Christopher;
Rowe, James C.;
Roscioli, Joseph R.;
Keutsch, Frank N.;
Kroll, Jesse H.

Publication type:

Article

Gamma-secretase inhibitor DAPT suppresses glioblastoma growth via uncoupling of tumor vessel density from vessel function.

Published in:

Clinical & Experimental Medicine, 2013, v. 13, n. 4, p. 271, doi. 10.1007/s10238-012-0203-8

By:

Zou, Yuhui;
Cao, Yiqun;
Yue, Zhijian;
Liu, Jianmin

Publication type:

Article

Herbal Mixture of Carthamus tinctorius L. Seed and Taraxacum coreanum Attenuates Amyloid Beta-Induced Cognitive Dysfunction In Vivo.

Published in:

Foods, 2022, v. 11, n. 2, p. 142, doi. 10.3390/foods11020142

By:

He, Meitong;
Kim, Jihyun;
Park, Chanhum;
Cho, Eunju

Publication type:

Article

Tongluo Xingnao effervescent tablet reverses memory deficit and reduces plaque load in APPswe/PS1dE9 mice.

Published in:

Experimental & Therapeutic Medicine, 2018, v. 15, n. 4, p. 4005, doi. 10.3892/etm.2018.5897

By:

Fu, Wenjun;
Dai, Yuan;
Ma, Tao;
Wei, Jiangping;
Chen, Huan;
Xu, Shijun

Publication type:

Article