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- Title
Different Sensitivity of Miniature Endplate Currents in Rat External and Internal Intercostal Muscles to the Acetylcholinesterase Inhibitor C-547 as Compared with Diaphragm and Extensor Digitorum Longus.
- Authors
PETROV, K.; KOVYAZINA, I.; ZOBOV, V.; BUKHARAEVA, E.; NIKOLSKY, E. E.; VYSKOCIL, F.
- Abstract
Derivative of 6-methyluracil, selective cholinesterase inhibitor C- 547 potentiates miniature endplate currents (MEPCs) in rat external intercostal muscles (external ICM) more effectively than in internal intercostal muscles (internal ICM). Effect of the C-547 on intercostal muscles was compared with those on extensor digitorum longus (EDL) and diaphragm muscles. Half-effective concentrations for t of MEPC decay arranged in increasing order were as follows: EDL, locomotor muscle, most sensitive = 1.3 nM, external ICM, inspiration muscle = 6.8 nM, diaphragm, main inspiration muscle = 28 nM, internal ICM, expiration muscle = 71 nM. External ICM might therefore be inhibited, similarly as the limb muscles, by nanomolar concentrations of the drug and do not participate in inspiration in the presence of the C-547. Moreover, internal ICM inhibition can hinder the expiration during exercise-induced fast breathing of C-547- treated experimental animals.
- Subjects
LABORATORY rats; ACETYLCHOLINESTERASE; MUSCULOSKELETAL system; INTERCOSTAL muscles; MUSCLES
- Publication
Physiological Research, 2009, Vol 58, Issue 1, p149
- ISSN
0862-8408
- Publication type
Academic Journal
- DOI
10.33549/physiolres.931698