Different Sensitivity of Miniature Endplate Currents of the Rat Extensor Digitorum Longus, Soleus and Diaphragm Muscles to a Novel Acetylcholinesterase Inhibitor C-547.

Petrov, K. A.; Kovyazina, I. V.; Zobov, V. V.; Bukharaeva, E. A.; Nikolsky, E. E.; Vyskočil, F.

A novel derivative of 6-methyluracil, C-547, increased the amplitude and prolonged the duration of miniature endplate currents (MEPCs) which is typical for acetylcholinesterase inhibition. In the soleus and extensor digitorum longus significant potentiation was detected at nanomolar concentrations. In contrast, in the diaphragm muscle, the increase in the amplitudes of the MEPCs and the decay time constant τ appeared only when the concentration of C-547 was elevated to 1x10-7 M. Possible consequences for the exploitation of this drug, which can selectively inhibit AChE in particular synapses, are discussed.

ACETYLCHOLINESTERASE; CHOLINESTERASE inhibitors; DIAPHRAGM (Anatomy); SYNAPSES; NERVES

Physiological Research, 2006, Vol 55, Issue 5, p585

0862-8408

Academic Journal

10.33549/physiolres.930980