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Title

High Dose Involved Field Radiation Therapy as Salvage for Loco-Regional Recurrence of Non-Small Cell Lung Cancer.

Authors

Sun Hyun Bae; Yong Chan Ahn; Heerim Nam; Hee Chul Park; Hong Ryull Pyo; Young Mog Shim; Jhingook Kim; Kwhanmien Kim; Jin Seok Ahn; Myung-Ju Ahn; Keunchil Park

Abstract

Purpose: To determine the effectiveness of salvage radiation therapy (RT) in patients with loco-regional recurrences (LRR) following initial complete resection of non-small cell lung cancer (NSCLC) and assess prognostic factors affecting survivals. Materials and Methods: Between 1994 and 2007, 64 patients with LRR after surgery of NSCLC were treated with high dose RT alone (78.1%) or concurrent chemo-radiation therapy (CCRT, 21.9%) at Samsung Medical Center. Twenty-nine patients (45.3%) had local recurrence, 26 patients (40.6%) had regional recurrence and 9 patients (14.1%) had recurrence of both components. The median RT dose was 54 Gy (range, 44-66 Gy). The radiation target volume included the recurrent lesions only. Results: The median follow-up time from the start of RT in survivors was 32.0 months. The rates of in-field failure free survival, intra-thoracic failure free survival and extra-thoracic failure free survival at 2 years were 52.3%, 33.9% and 59.4%, respectively. The median survival after RT was 18.5 months, and 2-year overall survival (OS) rate was 47.9%. On both univariate and multivariate analysis, the interval from surgery till recurrence and CCRT were significant prognostic factors for OS. Conclusion: The current study demonstrates that involved field salvage RT is effective for LRR of NSCLC following surgery.

Subjects

LUNG cancer treatment; CANCER radiotherapy; SALVAGE therapy; SURVIVAL analysis (Biometry); CANCER relapse; RADIATION doses

Publication

Yonsei Medical Journal, 2012, Vol 53, Issue 6, p1120

ISSN

0513-5796

Publication type

Academic Journal

DOI

10.3349/ymj.2012.53.6.1120

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