Comparative Antimicrobial Activities of some Monosaccharide and Disaccharide Acetates.

Matin, M. M.; Bhuiyan, M. M. H.; Afrin, A.; Debnath, D. C.

A number of furanose (2,4) and pyranose (5,7,9,11,13) acetates were prepared by direct acetylation method. For comparative antimicrobial studies sucrose octaacetate (14) was also prepared. All the compounds (1-14) were screened for in vitro antibacterial activity against ten human pathogenic bacteria viz. Bacillus subtilis, Bacillus cereus, Bacillus megaterium, Staphylococcus aureus, Escherichia coli, INABA ET (Vibrio), Pseudomonas species, Salmonella paratyphi, Salmonella typhi and Shigella dysenteriae. These compounds were also screened for in vitro antifungal activity against four pathogenic fungi viz. Aspergillus niger, Alternaria alternata, Curvularia lunata and Fusarium equiseti. The study revealed that the pyranose acetate derivatives (5,7,9,11,13) are more prone towards antimicrobial functionality than those of the furanose acetates (2,4) and sucrose octaacetate (14).

FURANOSIDES; ACETYLATION; SUCROSE; ASPERGILLUS niger; GLUCOPYRANOSE

Journal of Scientific Research, 2013, Vol 5, Issue 3, p515

2070-0237

Academic Journal

10.3329/jsr.v5i3.15695