Title: Multicomponent Reactions: Microwave-assisted Efficient Synthesis of Dihydropyrimidinones (thiones) and Quinazolinones under Green Chemistry Protocol as Probes for Antimicrobial Activities.
Authors: Bhuiyan, M. M. H.; Hamidunnessa; Mahmud, M. M.
Abstract: Microwave promoted diammonium hydrogen phosphate, (NH4)2HPO4, catalyzed three-component Biginelli reaction between an aldehyde, a 1,3-dicarbonyl compound and urea or thiourea under solvent-free conditions afforded the corresponding dihydropyrimidinones and quinazolinones in high yields. The synthesized compounds have been screened for their antimicrobial activity against Pseudomonas aeruginosa, Staphylococcus aureus, Vibrio choloriae, Shigella dysenteriae, Salmonella typhi bacteria and Aspargilllus flavus, Saccharomyces cerevisiae and Candida albicans fungi respectively. Some of the synthesized compounds exhibited pronounced antimicrobial activities.
Subjects: ALDEHYDES; QUINAZOLINONES; PSEUDOMONAS aeruginosa; SACCHAROMYCES cerevisiae; ANTI-infective agents
Publication: Journal of Scientific Research, 2012, Vol 4, Issue 1, p143
ISSN: 2070-0237
Publication type: Academic Journal
DOI: 10.3329/jsr.v4i1.8688

Multicomponent Reactions: Microwave-assisted Efficient Synthesis of Dihydropyrimidinones (thiones) and Quinazolinones under Green Chemistry Protocol as Probes for Antimicrobial Activities.

Bhuiyan, M. M. H.; Hamidunnessa; Mahmud, M. M.