Results
Title

Hepatoprotective effect of Chenopodium murale in mice.

Authors

Saleem, Mohammad; Ahmed, Bilal; Qadir, M. Imran; Mahrukh; Rafiq, Maria; Ahmad, Mubasher; Ahmad, Bashir

Abstract

Discovery of drugs has its roots in medicinal plants that appeal researchers to identify new therapeutical entities from plants. The current study was conducted to determine its hepatoprotective activity. The results showed that aqueous methanolic extract of Chenopodium murale (200 and 500 mg/kg) produced significant (p<0.001) decrease in paracetamol induced increased levels of liver enzymes (alanin transaminase, aspartate transaminase, alkaline phosphatase) and total bilirubin. These findings were further supported by histopathological investigations by microscope and detection of phytoconstituents having hepatoprotective potential e.g. qurecetin, kaempferol and gallic acid by HPLC. Conclusively aqueous methanolic extract of C. murale possess hepatoprotective activity against paracetamol induced liver damage in mice.

Subjects

AMARANTHACEAE; MEDICINAL plants; LIVER injuries; THERAPEUTICS; THERAPEUTIC use of plant extracts; ACETAMINOPHEN; ASPARTATE aminotransferase

Publication

Bangladesh Journal of Pharmacology, 2014, Vol 9, Issue 1, p124

ISSN

1991-007X

Publication type

Academic Journal

DOI

10.3329/bjp.v9i1.17785