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Title

ТР53 ТА ІОНІЗУЮЧЕ ВИПРОМІНЮВАННЯ: РОЛЬ В ПАТОГЕНЕЗІ І ПРОГНОЗУВАННІ ПЕРЕБІГУ ГОСТРОЇ МІЄЛОЇДНОЇ ЛЕЙКЕМІЇ (огляд літератури)

Authors

Любарець, Т. Ф.

Abstract

The review presents literature data on the role of the ТР53 gene and ionizing radiation (IR) in the pathogenesis of acute myeloid leukemia (AML). The violation of ТР53 functioning as a promoter of AML induction under the influence of negative external factors (IR, chemotherapeutic agents) was analyzed. New directions of AML stratification are presented, which will allow to optimize the future therapy and extend the life expectancy of this category of patients.

Subjects

ACUTE myeloid leukemia; IONIZING radiation; LIFE expectancy; CANCER chemotherapy; PATHOGENESIS

Publication

Problems of Radiation Medicine & Radiobiology, 2024, Issue 29, p67

ISSN

2304-8336

Publication type

Academic Journal

DOI

10.33145/2304-8336-2024-29-67-78

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