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- Title
ЗАКОНОМІРНОСТІ РОЗВИТКУ КЛІНІЧНИХ, ФУНКЦІОНАЛЬНИХ ПОРУШЕНЬ СТАНУ БРОНХОЛЕГЕНЕВОЇ СИСТЕМИ У ПІІСЛЯАВАРІЙНОМУ ПЕРІОДІ В ОСІБ, ЯКІ ЗАЗНАЛИ ВПЛИВУ ІОНІЗУЮЧОГО ВИПРОМІНЮВАННЯ
- Authors
Швайко, Л. І.; Базика, К. Д.; Шиленко, М. В.; Савченко, А. А.; Ткачук, Н. А.
- Abstract
The objective was to study the relationship between clinical symptoms and the functional state of the bronchopul monary system of cleanup workers of the Chornobyl Nuclear Power Plant accident with chronic obstructive pul monary disease in the remote postaccident period. Materials and methods. A retrospective analysis of 824 cases of COPD in male patients who underwent inpatient treatment in the radiation pulmonology department from 2014 to 2024 was conducted. The observation groups included 579 (70.3%) of cleanup workers (main group) and 245 (29.7%) of COPD patients (nosological control) who were irradiated within the natural background. For prospective observation, 100 COPD cleanup workers and 30 COPD patients from the nosological control group were selected. A complex of clinical and functional tests was provided. Results. In cleanup workers of Chornobyl NPP accident with COPD the regularities of damage to the bronchopul monary system under the influence of ionizing radiation should be considered a change in the minimal clinical symptoms of the early period, the rapid development of fibrotic changes in the lungs and bronchial mucosa, which is accompanied by a deepening of violations of functional pulmonary tests, structural and morphological changes according to the results of radiological research methods. Conclusions The analysis of various patterns and phenotypes of COPD requires further study in order to improve early diagnosis and treatment of the disease, in particular in people who have exposure to ionizing radiation.
- Subjects
NUCLEAR power plant accidents; IONIZING radiation; LUNGS; THERAPEUTICS; DIAGNOSIS
- Publication
Problems of Radiation Medicine & Radiobiology, 2024, Issue 29, p425
- ISSN
2304-8336
- Publication type
Academic Journal
- DOI
10.33145/2304-8336-2024-29-425-434