The pursuit of sustainable waste management solutions has led to the emergence of the oxidative liquefaction of municipal solid waste (MSW) as a promising approach for waste valorization. The primary objective of this study involves the investigation of a novel oxidative approach to decompose the integrated organic matrix of MSW into liquid-phase products of potential utility. The selected MSW samples have a carbon content of 50.30±0.50 %, as revealed through ultimate and proximate analysis. Oxidative liquefaction of MSW samples is carried out using a structured design of experiments. Temperature (200-300 °C), oxidant concentration (30- 60 %), waste-to-liquid ratio (3-7 %) were taken as experimental parameters. Liquid products were analyzed through gas chromatography with flame ionization detection (GC-FID), and oxygenated organic compounds (OOCs) were found to be in the range of 13-51 g/kg. Total solid reduction (TSR) was assumed as an indicator of the efficiency of the process. It was equal from 49 to 93 %. The current research article introduces the concept of oxidative liquefaction for treating MSW as a waste-to-fuel concept.