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Results: 140

Experimental designs for small randomised clinical trials: an algorithm for choice.
Published in:
2013
By:
- Cornu, Catherine;
- Kassai, Behrouz;
- Fisch, Roland;
- Chiron, Catherine;
- Alberti, Corinne;
- Guerrini, Renzo;
- Rosati, Anna;
- Pons, Gerard;
- Tiddens, Harm;
- Chabaud, Sylvie;
- Caudri, Daan;
- Ballot, Clément;
- Kurbatova, Polina;
- Castellan, Anne-Charlotte;
- Bajard, Agathe;
- Nony, Patrice;
- CRESim & Epi-CRESim Project Groups;
- Aarons, Leon;
- Bertrand, Yves;
- Bretz, Frank
Publication type:
journal article
One-sided Simultaneous Confidence Intervals for Effective Dose Steps in Unbalanced Designs.
Published in:
Biometrical Journal, 2000, v. 42, n. 8, p. 995, doi. 10.1002/1521-4036(200012)42:8<995::AID-BIMJ995>3.0.CO;2-4
By:
- Hothorn, Ludwig A.;
- Bretz, Frank
Publication type:
Article
Evaluation of Animal Carcinogenicity Studies: Cochran-Armitage Trend Test vs. Multiple Contrast Tests.
Published in:
Biometrical Journal, 2000, v. 42, n. 5, p. 553, doi. 10.1002/1521-4036(200009)42:5<553::AID-BIMJ553>3.0.CO;2-R
By:
- Hothorn, Ludwig A.;
- Bretz, Frank
Publication type:
Article
Efficient and easy-to-use sample size formulas in ratio-based non-inferiority tests.
Published in:
Journal of Applied Statistics, 2008, v. 35, n. 8, p. 893, doi. 10.1080/02664760802125544
By:
- Djira, GemechisD.;
- Guiard, Volker;
- Bretz, Frank
Publication type:
Article
Statistical calibration for infinite many future values in linear regression: simultaneous or pointwise tolerance intervals or what else?
Published in:
Journal of the Royal Statistical Society: Series C (Applied Statistics), 2023, v. 72, n. 1, p. 37, doi. 10.1093/jrsssc/qlac004
By:
- Han, Yang;
- Sun, Yujia;
- Wang, Lingjiao;
- Liu, Wei;
- Bretz, Frank
Publication type:
Article
Bayesian two-stage dose finding for cytostatic agents via model adaptation.
Published in:
Journal of the Royal Statistical Society: Series C (Applied Statistics), 2016, v. 65, n. 3, p. 465, doi. 10.1111/rssc.12129
By:
- Xu, Jiajing;
- Yin, Guosheng;
- Ohlssen, David;
- Bretz, Frank
Publication type:
Article
Simultaneous Confidence Tubes in Multivariate Linear Regression.
Published in:
Scandinavian Journal of Statistics, 2016, v. 43, n. 3, p. 879, doi. 10.1111/sjos.12217
By:
- Liu, Wei;
- Han, Yang;
- Wan, Fang;
- Bretz, Frank;
- Hayter, Anthony J.
Publication type:
Article
Simultaneous Tests and Confidence Intervals for the Evaluation of Agricultural Field Trials.
Published in:
Agronomy Journal, 2004, v. 96, n. 5, p. 1323, doi. 10.2134/agronj2004.1323
By:
- Frömke, Cornelia;
- Bretz, Frank
Publication type:
Article
Symmetric graphs for equally weighted tests, with application to the Hochberg procedure.
Published in:
2019
By:
- Xi, Dong;
- Bretz, Frank
Publication type:
journal article
Correction.
Published in:
2019
By:
- Bretz, Frank
Publication type:
corrected article
Flexible alpha allocation strategies for confirmatory adaptive enrichment clinical trials with a prespecified subgroup.
Published in:
2018
By:
- Sugitani, Toshifumi;
- Posch, Martin;
- Bretz, Frank;
- Koenig, Franz
Publication type:
journal article
Assessing the similarity of dose response and target doses in two non-overlapping subgroups.
Published in:
2018
By:
- Bretz, Frank;
- Möllenhoff, Kathrin;
- Dette, Holger;
- Liu, Wei;
- Trampisch, Matthias
Publication type:
journal article
Tutorial on statistical considerations on subgroup analysis in confirmatory clinical trials.
Published in:
2017
By:
- Alosh, Mohamed;
- Huque, Mohammad F.;
- Bretz, Frank;
- D'Agostino, Ralph B.;
- D'Agostino, Ralph B Sr
Publication type:
journal article
Estimands in clinical trials - broadening the perspective.
Published in:
2017
By:
- Akacha, Mouna;
- Bretz, Frank;
- Ruberg, Stephen
Publication type:
journal article
Comparing a stratified treatment strategy with the standard treatment in randomized clinical trials.
Published in:
2016
By:
- Sun, Hong;
- Bretz, Frank;
- Gerke, Oke;
- Vach, Werner
Publication type:
journal article
Model selection versus model averaging in dose finding studies.
Published in:
2016
By:
- Schorning, Kirsten;
- Bornkamp, Björn;
- Bretz, Frank;
- Dette, Holger
Publication type:
journal article
Authors' response to comments.
Published in:
2016
By:
- Bauer, Peter;
- Bretz, Frank;
- Dragalin, Vladimir;
- König, Franz;
- Wassmer, Gernot
Publication type:
journal article
Twenty-five years of confirmatory adaptive designs: opportunities and pitfalls.
Published in:
2016
By:
- Bauer, Peter;
- Bretz, Frank;
- Dragalin, Vladimir;
- König, Franz;
- Wassmer, Gernot;
- König, Franz
Publication type:
journal article
Multiplicity in confirmatory clinical trials: a case study with discussion from a JSM panel.
Published in:
2015
By:
- Wang, Sue‐Jane;
- Bretz, Frank;
- Dmitrienko, Alex;
- Hsu, Jason;
- Hung, H. M. James;
- Koch, Gary;
- Maurer, Willi;
- Offen, Walt;
- O'Neill, Robert
Publication type:
journal article
Seventh international French Society of Statistics meeting on statistical methods in biopharmacy: emerging topics for statistical methodology in clinical drug development.
Published in:
Statistics in Medicine, 2015, v. 34, n. 22, p. 2981, doi. 10.1002/sim.6570
By:
- Bretz, Frank
Publication type:
Article
A note on testing families of hypotheses using graphical procedures.
Published in:
Statistics in Medicine, 2014, v. 33, n. 30, p. 5340, doi. 10.1002/sim.6267
By:
- Maurer, Willi;
- Bretz, Frank
Publication type:
Article
Model-based dose finding under model uncertainty using general parametric models.
Published in:
Statistics in Medicine, 2014, v. 33, n. 10, p. 1646, doi. 10.1002/sim.6052
By:
- Pinheiro, José;
- Bornkamp, Björn;
- Glimm, Ekkehard;
- Bretz, Frank
Publication type:
Article
Advanced multiplicity adjustment methods in clinical trials.
Published in:
Statistics in Medicine, 2014, v. 33, n. 4, p. 693, doi. 10.1002/sim.5974
By:
- Alosh, Mohamed;
- Bretz, Frank;
- Huque, Mohammad
Publication type:
Article
Memory and other properties of multiple test procedures generated by entangled graphs.
Published in:
Statistics in Medicine, 2013, v. 32, n. 10, p. 1739, doi. 10.1002/sim.5711
By:
- Maurer, Willi;
- Bretz, Frank
Publication type:
Article
Joint EMA, ISBS, and DR-IBS International Symposium on Biopharmaceutical Statistics: Bridging drug development from research to marketing.
Published in:
Statistics in Medicine, 2013, v. 32, n. 10, p. 1619, doi. 10.1002/sim.5739
By:
- Koenig, Franz;
- Bretz, Frank
Publication type:
Article
On the efficiency of two-stage response-adaptive designs.
Published in:
Statistics in Medicine, 2013, v. 32, n. 10, p. 1646, doi. 10.1002/sim.5555
By:
- Dette, Holger;
- Bornkamp, Björn;
- Bretz, Frank
Publication type:
Article
Test and power considerations for multiple endpoint analyses using sequentially rejective graphical procedures.
Published in:
Statistics in Medicine, 2011, v. 30, n. 13, p. 1489, doi. 10.1002/sim.3988
By:
- Bretz, Frank;
- Maurer, Willi;
- Hommel, Gerhard
Publication type:
Article
Practical considerations for optimal designs in clinical dose finding studies.
Published in:
Statistics in Medicine, 2010, v. 29, n. 7/8, p. 731, doi. 10.1002/sim.3802
By:
- Bretz, Frank;
- Dette, Holger;
- Pinheiro, Jose C.
Publication type:
Article
Hierarchical testing of multiple endpoints in group-sequential trials.
Published in:
Statistics in Medicine, 2010, v. 29, n. 2, p. 219, doi. 10.1002/sim.3748
By:
- Glimm, Ekkehard;
- Maurer, Willi;
- Bretz, Frank
Publication type:
Article
Robustness considerations in selecting efficient two-color microarray designs.
Published in:
Bioinformatics, 2009, v. 25, n. 18, p. 2355, doi. 10.1093/bioinformatics/btp407
By:
- Latif, A. H. M. Mahbub;
- Bretz, Frank;
- Brunner, Edgar
Publication type:
Article
Efficient Two-Sample Designs for Microarray Experiments with Biological Replications.
Published in:
In Silico Biology, 2004, v. 4, n. 4, p. 461, doi. 10.3233/isb-00148
By:
- Landgrebe, Jobst;
- Bretz, Frank;
- Brunner, Edgar
Publication type:
Article
Authors' response.
Published in:
Statistical Methods in Medical Research, 2022, v. 31, n. 11, p. 2257, doi. 10.1177/09622802221111376
By:
- Liu, Wei;
- Bretz, Frank;
- Cortina-Borja, Mario
Publication type:
Article
Combined statistical decision limits based on two GH-2000 scores for the detection of growth hormone misuse.
Published in:
Statistical Methods in Medical Research, 2022, v. 31, n. 8, p. 1439, doi. 10.1177/09622802221093730
By:
- Liu, Wei;
- Bretz, Frank;
- Böhning, Dankmar;
- Holt, Richard I.G.;
- Han, Yang;
- Böhning, Walailuck;
- Guha, Nishan;
- Cowan, David A.
Publication type:
Article
Reference range: Which statistical intervals to use?
Published in:
Statistical Methods in Medical Research, 2021, v. 30, n. 2, p. 523, doi. 10.1177/0962280220961793
By:
- Liu, Wei;
- Bretz, Frank;
- Cortina-Borja, Mario
Publication type:
Article
Beyond Randomized Clinical Trials: Use of External Controls.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 806, doi. 10.1002/cpt.1723
By:
- Schmidli, Heinz;
- Häring, Dieter A.;
- Thomas, Marius;
- Cassidy, Adrian;
- Weber, Sebastian;
- Bretz, Frank
Publication type:
Article
Estimands—What they are and why they are important for pharmacometricians.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 4, p. 279, doi. 10.1002/psp4.12617
By:
- Akacha, Mouna;
- Bartels, Christian;
- Bornkamp, Björn;
- Bretz, Frank;
- Coello, Neva;
- Dumortier, Thomas;
- Looby, Michael;
- Sander, Oliver;
- Schmidli, Heinz;
- Steimer, Jean‐Louis;
- Vong, Camille
Publication type:
Article
Testing for similarity of multivariate mixed outcomes using generalized joint regression models with application to efficacy-toxicity responses.
Published in:
Biometrics, 2024, v. 80, n. 3, p. 1, doi. 10.1093/biomtc/ujae077
By:
- Hagemann, Niklas;
- Marra, Giampiero;
- Bretz, Frank;
- Möllenhoff, Kathrin
Publication type:
Article
Optimal test procedures for multiple hypotheses controlling the familywise expected loss.
Published in:
Biometrics, 2023, v. 79, n. 4, p. 2781, doi. 10.1111/biom.13907
By:
- Maurer, Willi;
- Bretz, Frank;
- Xun, Xiaolei
Publication type:
Article
Rejoinder to discussions on "Optimal test procedures for multiple hypotheses controlling the familywise expected loss".
Published in:
Biometrics, 2023, v. 79, n. 4, p. 2811, doi. 10.1111/biom.13905
By:
- Maurer, Willi;
- Bretz, Frank;
- Xun, Xiaolei
Publication type:
Article
Equivalence of regression curves sharing common parameters.
Published in:
Biometrics, 2020, v. 76, n. 2, p. 518, doi. 10.1111/biom.13149
By:
- Möllenhoff, Kathrin;
- Bretz, Frank;
- Dette, Holger
Publication type:
Article
Confidence sets for optimal factor levels of a response surface.
Published in:
Biometrics, 2016, v. 72, n. 4, p. 1285, doi. 10.1111/biom.12500
By:
- Wan, Fang;
- Liu, Wei;
- Bretz, Frank;
- Han, Yang
Publication type:
Article
Dose Response Signal Detection under Model Uncertainty.
Published in:
Biometrics, 2015, v. 71, n. 4, p. 996, doi. 10.1111/biom.12357
By:
- Dette, Holger;
- Titoff, Stefanie;
- Volgushev, Stanislav;
- Bretz, Frank
Publication type:
Article
Confirmatory adaptive designs with Bayesian decision tools for a targeted therapy in oncology.
Published in:
Statistics in Medicine, 2009, v. 28, n. 10, p. 1445, doi. 10.1002/sim.3559
By:
- Brannath, Werner;
- Zuber, Emmanuel;
- Branson, Michael;
- Bretz, Frank;
- Gallo, Paul;
- Posch, Martin;
- Racine-Poon, Amy
Publication type:
Article
Adaptive designs for confirmatory clinical trials.
Published in:
Statistics in Medicine, 2009, v. 28, n. 8, p. 1181, doi. 10.1002/sim.3538
By:
- Bretz, Frank;
- Koenig, Franz;
- Brannath, Werner;
- Glimm, Ekkehard;
- Posch, Martin
Publication type:
Article
A graphical approach to sequentially rejective multiple test procedures.
Published in:
Statistics in Medicine, 2009, v. 28, n. 4, p. 586, doi. 10.1002/sim.3495
By:
- Bretz, Frank;
- Maurer, Willi;
- Brannath, Werner;
- Posch, Martin
Publication type:
Article
Compatible simultaneous lower confidence bounds for the Holm procedure and other Bonferroni-based closed tests.
Published in:
Statistics in Medicine, 2008, v. 27, n. 24, p. 4914, doi. 10.1002/sim.3338
By:
- Strassburger, Klaus;
- Bretz, Frank
Publication type:
Article
Adaptive Dunnett tests for treatment selection.
Published in:
Statistics in Medicine, 2008, v. 27, n. 10, p. 1612, doi. 10.1002/sim.3048
By:
- Koenig, Franz;
- Brannath, Werner;
- Bretz, Frank;
- Posch, Martin
Publication type:
Article
Bayesian predictive power for interim adaptation in seamless phase II/III trials where the endpoint is survival up to some specified timepoint.
Published in:
Statistics in Medicine, 2007, v. 26, n. 27, p. 4925, doi. 10.1002/sim.2957
By:
- Schmidli, Heinz;
- Bretz, Frank;
- Racine-Poon, Amy
Publication type:
Article
Powerful short-cuts for multiple testing procedures with special reference to gatekeeping strategies.
Published in:
Statistics in Medicine, 2007, v. 26, n. 22, p. 4063, doi. 10.1002/sim.2873
By:
- Hommel, Gerhard;
- Bretz, Frank;
- Maurer, Willi
Publication type:
Article
Power and sample size computations in simultaneous tests for non-inferiority based on relative margins.
Published in:
Statistics in Medicine, 2006, v. 25, n. 7, p. 1131, doi. 10.1002/sim.2359
By:
- Dilba, Gemechis;
- Bretz, Frank;
- Hothorn, Ludwig A.;
- Guiard, Volker
Publication type:
Article