Works matching DE "ALPHA-synuclein"

Results: 1497

Are Preformed Fibrils a Model of Parkinson's Disease?

Published in:

Journal of Parkinson's Disease, 2024, v. 14, n. 6, p. 1095, doi. 10.3233/JPD-240228

By:

Woerman, Amanda L.;
Luk, Kelvin C.

Publication type:

Article

Colonoscopy and Subsequent Risk of Parkinson's Disease.

Published in:

Journal of Parkinson's Disease, 2024, v. 14, n. 4, p. 747, doi. 10.3233/JPD-240017

By:

Holtz, Anna-Victoria;
Fink, Anne;
Tamgüney, Gültekin;
Doblhammer, Gabriele

Publication type:

Article

Association of Misfolded α-Synuclein Derived from Neuronal Exosomes in Blood with Parkinson's Disease Diagnosis and Duration.

Published in:

Journal of Parkinson's Disease, 2024, v. 14, n. 4, p. 667, doi. 10.3233/JPD-230390

By:

Schaeffer, Eva;
Kluge, Annika;
Schulte, Claudia;
Deuschle, Christian;
Bunk, Josina;
Welzel, Julius;
Maetzler, Walter;
Berg, Daniela

Publication type:

Article

Automated Capillary Electrophoresis Immunoblot for the Detection of Alpha-Synuclein in Mouse Tissue.

Published in:

Journal of Parkinson's Disease, 2024, v. 14, n. 4, p. 681, doi. 10.3233/JPD-230379

By:

Erdmann, Leonie;
Santos, Patrícia I.;
Rieper, Petra;
Klafki, Hans W.;
Beutner, Dirk;
Wiltfang, Jens;
Outeiro, Tiago F.;
Setz, Cristian

Publication type:

Article

Defining a Lewy Body: Running Up the Hill of Shifting Definitions and Evolving Concepts.

Published in:

Journal of Parkinson's Disease, 2024, v. 14, n. 1, p. 17, doi. 10.3233/JPD-230183

By:

Moors, Tim E.;
Milovanovic, Dragomir

Publication type:

Article

Prevalence of Concomitant Pathologies in Parkinson's Disease: Implications for Prognosis, Diagnosis, and Insights into Common Pathogenic Mechanisms.

Published in:

Journal of Parkinson's Disease, 2024, v. 14, n. 1, p. 35, doi. 10.3233/JPD-230154

By:

Walker, Lauren;
Attems, Johannes

Publication type:

Article

Alpha-Synuclein Pre-Formed Fibrils Injected into Prefrontal Cortex Primarily Spread to Cortical and Subcortical Structures.

Published in:

Journal of Parkinson's Disease, 2024, v. 14, n. 1, p. 81, doi. 10.3233/JPD-230129

By:

Weber, Matthew A.;
Kerr, Gemma;
Thangavel, Ramasamy;
Conlon, Mackenzie M.;
Gumusoglu, Serena B.;
Gupta, Kalpana;
Abdelmotilib, Hisham A.;
Halhouli, Oday;
Zhang, Qiang;
Geerling, Joel C.;
Narayanan, Nandakumar S.;
Aldridge, Georgina M.

Publication type:

Article

Astrocytes and Alpha-Synuclein: Friend or Foe?

Published in:

Journal of Parkinson's Disease, 2023, v. 13, n. 8, p. 1289, doi. 10.3233/JPD-230284

By:

Ozoran, Hakan;
Srinivasan, Rahul

Publication type:

Article

Distinct Patterns of Gene Expression Changes in the Colon and Striatum of Young Mice Overexpressing Alpha-Synuclein Support Parkinson's Disease as a Multi-System Process.

Published in:

Journal of Parkinson's Disease, 2023, v. 13, n. 7, p. 1127, doi. 10.3233/JPD-223568

By:

Videlock, Elizabeth J.;
Hatami, Asa;
Zhu, Chunni;
Kawaguchi, Riki;
Chen, Han;
Khan, Tasnin;
Yehya, Ashwaq Hamid Salem;
Stiles, Linsey;
Joshi, Swapna;
Hoffman, Jill M.;
Law, Ka Man;
Rankin, Carl Robert;
Chang, Lin;
Maidment, Nigel T.;
John, Varghese;
Geschwind, Daniel H.;
Pothoulakis, Charalabos

Publication type:

Article

Parkinson's Progression Markers Initiative: A Milestone-Based Strategy to Monitor Parkinson's Disease Progression.

Published in:

Journal of Parkinson's Disease, 2023, v. 13, n. 6, p. 899, doi. 10.3233/JPD-223433

By:

Brumm, Michael C.;
Siderowf, Andrew;
Simuni, Tanya;
Burghardt, Elliot;
Choi, Seung Ho;
Caspell-Garcia, Chelsea;
Chahine, Lana M.;
Mollenhauer, Brit;
Foroud, Tatiana;
Galasko, Douglas;
Merchant, Kalpana;
Arnedo, Vanessa;
Hutten, Samantha J.;
O'Grady, Alyssa N.;
Poston, Kathleen L.;
Tanner, Caroline M.;
Weintraub, Daniel;
Kieburtz, Karl;
Marek, Kenneth;
Coffey, Christopher S.

Publication type:

Article

RAGE Against the Glycation Machine in Synucleinopathies: Time to Explore New Questions.

Published in:

Journal of Parkinson's Disease, 2023, v. 13, n. 5, p. 717, doi. 10.3233/JPD-230070

By:

Gelain, Daniel Pens;
Bittencourt, Reykla Ramon;
Bastos Mendes, Luiz Filipe;
Moreira, José Claudio Fonseca;
Outeiro, Tiago Fleming

Publication type:

Article

Immunological Features of LRRK2 Function and Its Role in the Gut-Brain Axis Governing Parkinson's Disease.

Published in:

Journal of Parkinson's Disease, 2023, v. 13, n. 3, p. 279, doi. 10.3233/JPD-230021

By:

Peter, Inga;
Strober, Warren

Publication type:

Article

miR-101a-3p Impairs Synaptic Plasticity and Contributes to Synucleinopathy.

Published in:

Journal of Parkinson's Disease, 2023, v. 13, n. 2, p. 179, doi. 10.3233/JPD-225055

By:

Xylaki, Mary;
Paiva, Isabel;
Al-Azzani, Mohammed;
Gerhardt, Ellen;
Jain, Gaurav;
Islam, Md Rezaul;
Vasili, Eftychia;
Wassouf, Zinah;
Schulze-Hentrich, Julia M.;
Fischer, André;
Outeiro, Tiago Fleming

Publication type:

Article

Specific Detection of Physiological S129 Phosphorylated α-Synuclein in Tissue Using Proximity Ligation Assay.

Published in:

Journal of Parkinson's Disease, 2023, v. 13, n. 2, p. 255, doi. 10.3233/JPD-213085

By:

Arlinghaus, Ryan;
Iba, Michiyo;
Masliah, Eliezer;
Cookson, Mark R.;
Landeck, Natalie

Publication type:

Article

A Combined α-Synuclein/Fibril (SynFib) Model of Parkinson-Like Synucleinopathy Targeting the Nigrostriatal Dopamine System.

Published in:

Journal of Parkinson's Disease, 2022, v. 12, n. 8, p. 2307, doi. 10.3233/JPD-223452

By:

Björklund, Anders;
Nilsson, Fredrik;
Mattsson, Bengt;
Hoban, Deirdre B.;
Parmar, Malin

Publication type:

Article

Phosphorylated α-Synuclein Deposits in Cutaneous Nerves of Early Parkinsonism.

Published in:

Journal of Parkinson's Disease, 2022, v. 12, n. 8, p. 2453, doi. 10.3233/JPD-223421

By:

Nolano, Maria;
Caporaso, Giuseppe;
Manganelli, Fiore;
Stancanelli, Annamaria;
Borreca, Ilaria;
Mozzillo, Stefania;
Tozza, Stefano;
Dubbioso, Raffaele;
Iodice, Rosa;
Vitale, Floriana;
Koay, Shiwen;
Vichayanrat, Ekawat;
da Silva, Fernanda Valerio;
Santoro, Lucio;
Iodice, Valeria;
Provitera, Vincenzo

Publication type:

Article

Early-Onset Parkinson's Disease: Creating the Right Environment for a Genetic Disorder.

Published in:

Journal of Parkinson's Disease, 2022, v. 12, n. 8, p. 2353, doi. 10.3233/JPD-223380

By:

Kolicheski, Ana;
Turcano, Pierpaolo;
Tamvaka, Nicole;
McLean, Pamela J.;
Springer, Wolfdieter;
Savica, Rodolfo;
Ross, Owen A.

Publication type:

Article

Role of NLRP3 Inflammasome in Parkinson's Disease and Therapeutic Considerations.

Published in:

Journal of Parkinson's Disease, 2022, v. 12, n. 7, p. 2117, doi. 10.3233/JPD-223290

By:

Nguyen, Linh Thi Nhat;
Nguyen, Huu Dat;
Kim, Yun Joong;
Nguyen, Tinh Thi;
Lai, Thuy Thi;
Lee, Yoon Kyoung;
Ma, Hyeo-il;
Kim, Young Eun

Publication type:

Article

Dual Effects: Intrastriatal Injection of α-syn N103/tau N368 Preformed Fibrils Promotes Endogenous α-synuclein Aggregates in the Proximal Colon.

Published in:

Journal of Parkinson's Disease, 2022, v. 12, n. 7, p. 2097, doi. 10.3233/JPD-223294

By:

Wang, Jialing;
Yang, Xiaoman;
Zeng, Weiqi;
Zhang, Xiaoqian;
Yang, Xiaomei;
Xu, Yu;
Liu, Ke;
Zhang, Zhaoyuan;
Xu, Yan;
Cao, Xuebing

Publication type:

Article

Inflammasome Activation in Parkinson's Disease.

Published in:

Journal of Parkinson's Disease, 2022, v. 12, p. S113, doi. 10.3233/JPD-223338

By:

Jewell, Shannon;
Herath, Ashane M.;
Gordon, Richard;
Bloem, Bastiaan R.;
Brundin, Patrik;
Tan, Eng King;
Harms, Ashley;
Lindestam Arlehamn, Cecilia;
Williams-Gray, Caroline

Publication type:

Article

Microglia in Parkinson's Disease.

Published in:

Journal of Parkinson's Disease, 2022, v. 12, p. S105, doi. 10.3233/JPD-223237

By:

Stefanova, Nadia;
Bloem, Bastiaan R.;
Brundin, Patrik;
Tan, Eng King;
Harms, Ashley;
Lindestam Arlehamn, Cecilia;
Williams-Gray, Caroline

Publication type:

Article

Inflammatory Animal Models of Parkinson's Disease.

Published in:

Journal of Parkinson's Disease, 2022, v. 12, p. S165, doi. 10.3233/JPD-213138

By:

García-Revilla, Juan;
Herrera, Antonio J.;
de Pablos, Rocío M.;
Venero, José Luis;
Bloem, Bastiaan R.;
Brundin, Patrik;
Tan, Eng King;
Harms, Ashley;
Lindestam Arlehamn, Cecilia;
Williams-Gray, Caroline

Publication type:

Article

Comparative Analysis of Total Alpha-Synuclein (αSYN) Immunoassays Reveals That They Do Not Capture the Diversity of Modified αSYN Proteoforms.

Published in:

Journal of Parkinson's Disease, 2022, v. 12, n. 5, p. 1449, doi. 10.3233/JPD-223285

By:

Petricca, Lara;
Chiki, Nour;
Hanna-El-Daher, Layane;
Aeschbach, Lorène;
Burai, Ritwik;
Stoops, Erik;
Fares, Mohamed-Bilal;
Lashuel, Hilal A.

Publication type:

Article

Disease-Modifying Therapies for Multiple System Atrophy: Where Are We in 2022?

Published in:

Journal of Parkinson's Disease, 2022, v. 12, n. 5, p. 1369, doi. 10.3233/JPD-223183

By:

Sidoroff, Victoria;
Bower, Pam;
Stefanova, Nadia;
Fanciulli, Alessandra;
Stankovic, Iva;
Poewe, Werner;
Seppi, Klaus;
Wenning, Gregor K.;
Krismer, Florian

Publication type:

Article

The proSAAS Chaperone Provides Neuroprotection and Attenuates Transsynaptic α-Synuclein Spread in Rodent Models of Parkinson's Disease.

Published in:

Journal of Parkinson's Disease, 2022, v. 12, n. 5, p. 1463, doi. 10.3233/JPD-213053

By:

Lindberg, Iris;
Shu, Zhan;
Lam, Hoa;
Helwig, Michael;
Yucer, Nur;
Laperle, Alexander;
Svendsen, Clive N.;
Di Monte, Donato A.;
Maidment, Nigel T.

Publication type:

Article

Cardiac Alpha-Synuclein Is Present in Alpha-Synucleinopathies.

Published in:

Journal of Parkinson's Disease, 2022, v. 12, n. 4, p. 1125, doi. 10.3233/JPD-223161

By:

Javanshiri, Keivan;
Drakenberg, Tove;
Haglund, Mattias;
Englund, Elisabet

Publication type:

Article

Sequential or Simultaneous Injection of Preformed Fibrils and AAV Overexpression of Alpha-Synuclein Are Equipotent in Producing Relevant Pathology and Behavioral Deficits.

Published in:

Journal of Parkinson's Disease, 2022, v. 12, n. 4, p. 1133, doi. 10.3233/JPD-212555

By:

Negrini, Matilde;
Tomasello, Giuseppe;
Davidsson, Marcus;
Fenyi, Alexis;
Adant, Cécile;
Hauser, Swantje;
Espa, Elena;
Gubinelli, Francesco;
Manfredsson, Fredric P.;
Melki, Ronald;
Heuer, Andreas

Publication type:

Article

Presence of Skin α-Synuclein Deposits Discriminates Parkinson's Disease from Progressive Supranuclear Palsy and Corticobasal Syndrome.

Published in:

Journal of Parkinson's Disease, 2022, v. 12, n. 2, p. 585, doi. 10.3233/JPD-212904

By:

Giannoccaro, Maria Pia;
Avoni, Patrizia;
Rizzo, Giovanni;
Incensi, Alex;
Infante, Rossella;
Donadio, Vincenzo;
Liguori, Rocco

Publication type:

Article

The Compound ATH434 Prevents Alpha-Synuclein Toxicity in a Murine Model of Multiple System Atrophy.

Published in:

Journal of Parkinson's Disease, 2022, v. 12, n. 1, p. 105, doi. 10.3233/JPD-212877

By:

Finkelstein, David I.;
Shukla, Jay J.;
Cherny, Robert A.;
Billings, Jessica L.;
Saleh, Eiman;
Stefanova, Nadia;
Barnham, Kevin J.;
Adlard, Paul A.

Publication type:

Article

A Summary of Phenotypes Observed in the In Vivo Rodent Alpha-Synuclein Preformed Fibril Model.

Published in:

Journal of Parkinson's Disease, 2021, v. 11, n. 4, p. 1555, doi. 10.3233/JPD-212847

By:

Polinski, Nicole K.

Publication type:

Article

Comparison of Different Platform Immunoassays for the Measurement of Plasma Alpha-Synuclein in Parkinson's Disease Patients.

Published in:

Journal of Parkinson's Disease, 2021, v. 11, n. 4, p. 1761, doi. 10.3233/JPD-212694

By:

Youssef, Priscilla;
Kim, Woojin S.;
Halliday, Glenda M.;
Lewis, Simon J.G.;
Dzamko, Nicolas

Publication type:

Article

Effects of Alpha-Synuclein Targeted Antisense Oligonucleotides on Lewy Body-Like Pathology and Behavioral Disturbances Induced by Injections of Pre-Formed Fibrils in the Mouse Motor Cortex.

Published in:

Journal of Parkinson's Disease, 2021, v. 11, n. 3, p. 1091, doi. 10.3233/JPD-212566

By:

Boutros, Sydney Weber;
Raber, Jacob;
Unni, Vivek K.

Publication type:

Article

Detection of Dermal Alpha-Synuclein Deposits as a Biomarker for Parkinson's Disease.

Published in:

Journal of Parkinson's Disease, 2021, v. 11, n. 3, p. 937, doi. 10.3233/JPD-202489

By:

Doppler, Kathrin

Publication type:

Article

Gene Therapy to Modulate Alpha-Synuclein in Synucleinopathies.

Published in:

Journal of Parkinson's Disease, 2021, v. 11, p. S189, doi. 10.3233/JPD-212679

By:

Sandoval, Ivette M.;
Marmion, David J.;
Meyers, Kimberly T.;
Manfredsson, Fredric P.;
Björklund, Anders;
Bloem, Bastiaan R.;
Brundin, Patrik;
Federoff, Howard

Publication type:

Article

Treating Parkinson's Disease with Antibodies: Previous Studies and Future Directions.

Published in:

Journal of Parkinson's Disease, 2021, v. 11, n. 1, p. 71, doi. 10.3233/JPD-202221

By:

Castonguay, Anne-Marie;
Gravel, Claude;
Lévesque, Martin

Publication type:

Article

Crosstalk Between Alpha-Synuclein and Other Human and Non-Human Amyloidogenic Proteins: Consequences for Amyloid Formation in Parkinson's Disease.

Published in:

Journal of Parkinson's Disease, 2020, v. 10, n. 3, p. 819, doi. 10.3233/JPD-202085

By:

Werner, Tony;
Horvath, Istvan;
Wittung-Stafshede, Pernilla

Publication type:

Article

Serum Uric Acid Level as a Biomarker in Idiopathic and Genetic (p.A53T Alpha-Synuclein Carriers) Parkinson's Disease: Data from the PPMI Study.

Published in:

Journal of Parkinson's Disease, 2020, v. 10, n. 2, p. 481, doi. 10.3233/JPD-191860

By:

Koros, Christos;
Simitsi, Athina-Maria;
Papadimitriou, Dimitra;
Bougea, Anastasia;
Prentakis, Andreas;
Papagiannakis, Nikolaos;
Pachi, Ioanna;
Bozi, Maria;
Antonelou, Roubina;
Angelopoulou, Efthalia;
Beratis, Ion;
Papageorgiou, Sokratis G.;
Trapali, Xenia Geronicola;
Stamelou, Maria;
Stefanis, Leonidas

Publication type:

Article

Gastrointestinal Immunity and Alpha-Synuclein.

Published in:

Journal of Parkinson's Disease, 2019, v. 9, p. S313, doi. 10.3233/JPD-191702

By:

Barbut, Denise;
Stolzenberg, Ethan;
Zasloff, Michael;
van Laar, Teus

Publication type:

Article

Revisiting the History of the 1997 Alpha-Synuclein Discovery in Parkinson's Disease.

Published in:

2019

By:

Polymeropoulos, Mihael H.

Publication type:

Letter

Clinical Trial Highlights: Targetting Alpha-Synuclein.

Published in:

Journal of Parkinson's Disease, 2019, v. 9, n. 1, p. 5, doi. 10.3233/JPD-189004

By:

McFarthing, Kevin;
Simuni, Tanya

Publication type:

Article

A Proposed Roadmap for Parkinson's Disease Proof of Concept Clinical Trials Investigating Compounds Targeting Alpha-Synuclein.

Published in:

Journal of Parkinson's Disease, 2019, v. 9, n. 1, p. 31, doi. 10.3233/JPD-181471

By:

Merchant, Kalpana M.;
Cedarbaum, Jesse M.;
Brundin, Patrik;
Dave, Kuldip D.;
Eberling, Jamie;
Espay, Alberto J.;
Hutten, Samantha J.;
Javidnia, Monica;
Luthman, Johan;
Maetzler, Walter;
Menalled, Liliana;
Reimer, Alyssa N.;
Stoessl, A. Jon;
Weiner, David M.

Publication type:

Article

Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson’s Disease in Rodents.

Published in:

Journal of Parkinson's Disease, 2018, v. 8, n. 2, p. 303, doi. 10.3233/JPD-171248

By:

Polinski, Nicole K.;
Volpicelli-Daley, Laura A.;
Sortwell, Caryl E.;
Luk, Kelvin C.;
Cremades, Nunilo;
Gottler, Lindsey M.;
Froula, Jessica;
Duffy, Megan F.;
Lee, Virginia M.Y.;
Martinez, Terina N.;
Dave, Kuldip D.

Publication type:

Article

Glucocerebrosidase Mutations in Parkinson Disease.

Published in:

Journal of Parkinson's Disease, 2017, v. 7, n. 3, p. 411, doi. 10.3233/JPD-171092

By:

O'Regan, Grace;
deSouza, Ruth-Mary;
Balestrino, Roberta;
Schapir, Anthony H.

Publication type:

Article

Cutaneous Alpha-Synuclein From Paraffin Embedded Autopsy Specimens in Parkinson's Disease.

Published in:

Journal of Parkinson's Disease, 2017, v. 7, n. 3, p. 503, doi. 10.3233/JPD-171088

By:

Gibbons, Christopher H.;
Wang, Ningshan;
Freeman, Roy

Publication type:

Article

The Identification of Alpha-Synuclein as the First Parkinson Disease Gene.

Published in:

Journal of Parkinson's Disease, 2017, v. 7, p. S45, doi. 10.3233/JPD-179003

By:

Nussbaum, Robert L.

Publication type:

Article

Multicenter Assessment of Immunohistochemical Methods for Pathological Alpha-Synuclein in Sigmoid Colon of Autopsied Parkinson's Disease and Control Subjects.

Published in:

Journal of Parkinson's Disease, 2016, v. 6, n. 4, p. 761, doi. 10.3233/JPD-160888

By:

Beach, Thomas G.;
Corbillé, Anne-Gaëlle;
Letournel, Franck;
Kordower, Jeffrey H.;
Kremer, Thomas;
Munoz, David G.;
Intorcia, Anthony;
Hentz, Joseph;
Adler, Charles H.;
Sue, Lucia I.;
Walker, Jessica;
Serrano, Geidy;
Derkinderen, Pascal

Publication type:

Article

Reduction of Immunoreactivity Against the C-Terminal Region of the Intracellular α-Synuclein by Exogenous α-Synuclein Aggregates: Possibility of Conformational Changes.

Published in:

Journal of Parkinson's Disease, 2016, v. 6, n. 3, p. 569, doi. 10.3233/JPD-160835

By:

Yasuhiko Izumi;
Naoto Kondo;
Ryosuke Takahashi;
Akinori Akaike;
Toshiaki Kume

Publication type:

Article

An Efficient Procedure for Removal and Inactivation of Alpha-Synuclein Assemblies from Laboratory Materials.

Published in:

Journal of Parkinson's Disease, 2016, v. 6, n. 1, p. 143, doi. 10.3233/JPD-150691

By:

Bousset, Luc;
Brundin, Patrik;
Böckmann, Anja;
Meierd, Beat;
Melki, Ronald

Publication type:

Article

Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?

Published in:

Journal of Parkinson's Disease, 2016, v. 6, n. 1, p. 39, doi. 10.3233/JPD-160779

By:

Oueslati, Abid

Publication type:

Article

Role of α-Synuclein in Inducing Innate and Adaptive Immunity in Parkinson Disease.

Published in:

Journal of Parkinson's Disease, 2015, v. 5, n. 1, p. 1, doi. 10.3233/JPD-140491

By:

Allen Reish, Heather E.;
Standaert, David G.

Publication type:

Article