DESIGN, SYNTHESIS, CHARACTERIZATION, AND CYTOTOXICITY EVALUATION OF NEW 4-BENZYL-1,3-OXAZOLE DERIVATIVES BEARING 4-(4-CHLOROPHENYLSULFONYL)PHENYL MOIETY.

APOSTOL, THEODORA-VENERA; SOCEA, LAURA-ILEANA; DRĂGHICI, CONSTANTIN; OLARU, OCTAVIAN TUDOREL; ȘARAMET, GABRIEL; ENACHE-PREOTEASA, CRISTIAN; BĂRBUCEANU, ȘTEFANIA-FELICIA

This paper presents the design, synthesis, characterization, and cytotoxicity evaluation of eight organic compounds that have in their molecules the 4-(4-chlorophenylsulfonyl)phenyl moiety: four acyclic precursors derived from phenylalanine (one Nacyl- α-amino acid, one N-acyl-α-amino acyl chloride, and two N-acyl-α-amino ketones), and four cyclization products: one 1,3-oxazol-5(4H)-one, and three 1,3-oxazoles substituted in 5-position with phenyl, p-tolyl, and m-xylyl group, respectively. Structures of synthesized compounds were confirmed by elemental analysis and spectral methods (UV-Vis, FT-IR, MS, ¹H-and 13C-NMR). The compounds purity determination was performed by RP-HPLC. Cytotoxic effect of synthesized compounds was evaluated on Daphnia magna crustacean.

MOIETIES (Chemistry); ACYL chlorides; DAPHNIA magna; CHEMICAL synthesis; ORGANIC compounds

Farmacia, 2021, Vol 69, Issue 2, p314

0014-8237

Academic Journal

10.31925/farmacia.2021.2.17