Synthesis of non-glutamate-type pyrrolo[2,3-d]pyrimidines via direct aminocarbonylation of aryl halides using solid Co₂(CO)₈ as a CO source and their antibacterial activity.

Selvakumar, Balaraman; Elango, Kuppanagounder P.

The synthesis of pyrrolo[2,3-d]pyrimidine derivatives by direct aminocarbonylation was demonstrated using solid Co2(CO)8 as a CO source in an autoclave at elevated temperature by reacting an aryl halide scaffold with a variety of amines. Using this method, 12 non-glutamatetype pyrrolo[2,3-d]pyrimidine analogues were prepared. Some compounds exhibited antibacterial activity against both Gram-positive and Gram-negative bacteria.

CARBONYLATION; ARYL halides; PYRIMIDINES; ANTIBACTERIAL agents; GLUTAMIC acid

Journal of Chemical Research, 2017, Vol 41, Issue 4, p230

1747-5198

Academic Journal

10.3184/174751917X14894997017658