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Title: Synthesis of non-glutamate-type pyrrolo[2,3-d]pyrimidines via direct aminocarbonylation of aryl halides using solid Co<sub>2</sub>(CO)<sub>8</sub> as a CO source and their antibacterial activity.
Authors: Selvakumar, Balaraman; Elango, Kuppanagounder P.
Abstract: The synthesis of pyrrolo[2,3-d]pyrimidine derivatives by direct aminocarbonylation was demonstrated using solid Co2(CO)8 as a CO source in an autoclave at elevated temperature by reacting an aryl halide scaffold with a variety of amines. Using this method, 12 non-glutamatetype pyrrolo[2,3-d]pyrimidine analogues were prepared. Some compounds exhibited antibacterial activity against both Gram-positive and Gram-negative bacteria.
Subjects: CARBONYLATION; ARYL halides; PYRIMIDINES; ANTIBACTERIAL agents; GLUTAMIC acid
Publication: Journal of Chemical Research, 2017, Vol 41, Issue 4, p230
ISSN: 1747-5198
Publication type: Academic Journal
DOI: 10.3184/174751917X14894997017658

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Synthesis of non-glutamate-type pyrrolo[2,3-d]pyrimidines via direct aminocarbonylation of aryl halides using solid Co<sub>2</sub>(CO)<sub>8</sub> as a CO source and their antibacterial activity.