Works matching DE "CYCLOPAMINE"

Results: 58

Hedgehog signaling is activated in canine transitional cell carcinoma and contributes to cell proliferation and survival.

Published in:

Veterinary & Comparative Oncology, 2017, v. 15, n. 1, p. 174, doi. 10.1111/vco.12149

By:

Gustafson, T. L.;
Kitchell, B. E.;
Biller, B.

Publication type:

Article

The sonic hedgehog pathway mediates Tongxinluo capsule‐induced protection against blood‐brain barrier disruption after ischaemic stroke in mice.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2019, v. 124, n. 6, p. 660, doi. 10.1111/bcpt.13186

By:

Liu, Shen;
Chang, Liping;
Wei, Cong

Publication type:

Article

Effects of cyclopamine on the biological characteristics of human breast cancer MCF-7 cell line and its mechanism.

Published in:

European Journal of Gynaecological Oncology, 2015, v. 36, n. 4, p. 469, doi. 10.12892/ejgo2670.2015

By:

Zhu, D. M.;
Xue, W. L.;
Tao, W.;
Li, J. C.

Publication type:

Article

Effects and mechanisms of blocking the hedgehog signaling pathway in human gastric cancer cells.

Published in:

Oncology Letters, 2015, v. 9, n. 5, p. 1997, doi. 10.3892/ol.2015.3032

By:

HONGBING GU;
XU LI;
CONGZHI ZHOU;
YUGANG WEN;
YANG SHEN;
LISHENG ZHOU;
JIKUN LI

Publication type:

Article

Sonic hedgehog and androgen signaling in tumor and stromal compartments drives epithelial-mesenchymal transition in prostate cancer.

Published in:

Scandinavian Journal of Urology (Taylor & Francis Ltd), 2014, v. 48, n. 6, p. 523, doi. 10.3109/21681805.2014.898336

By:

Yamamichi, Fukashi;
Shigemura, Katsumi;
Behnsawy, Hosny M.;
Meligy, Fatma Y.;
Huang, Wen-Chin;
Li, Xiangyan;
Yamanaka, Kunito;
Hanioka, Keisuke;
Miyake, Hideaki;
Tanaka, Kazushi;
Kawabata, Masato;
Shirakawa, Toshiro;
Fujisawa, Masato

Publication type:

Article

Ni(ClO<sub>4</sub>)<sub>2</sub>‐Catalyzed Friedel–Crafts Reaction of Coumarin‐Fused Donor–Acceptor Cyclopropanes with Indoles: Stereoselective Synthesis of trans‐3,4‐Disubstituted‐3,4‐dihydrocoumarins.

Published in:

European Journal of Organic Chemistry, 2018, v. 2018, n. 30, p. 4166, doi. 10.1002/ejoc.201800669

By:

Lee, Jusung;
Ko, Kwang Min;
Kim, Sung‐Gon

Publication type:

Article

New Spiro‐Lactam C‐nor‐D‐homo Steroids.

Published in:

European Journal of Organic Chemistry, 2018, v. 2018, n. 30, p. 4147, doi. 10.1002/ejoc.201800667

By:

Roumana, Aggeliki;
Yektaoğlu, Aybike;
Pliatsika, Dimanthi;
Bantzi, Marina;
Nikolaropoulos, Sotiris S.;
Giannis, Athanassios;
Fousteris, Manolis A.

Publication type:

Article

Activated hedgehog pathway is a potential target for pharmacological intervention in biliary tract cancer.

Published in:

Molecular & Cellular Biochemistry, 2014, v. 396, n. 1/2, p. 257, doi. 10.1007/s11010-014-2161-9

By:

Kiesslich, Tobias;
Wachter, Julia;
Ocker, Matthias;
Mayr, Christian;
Bach, Doris;
Fuereder, Julia;
Wagner, Andrej;
Berr, Frieder;
Alinger, Beate;
Neureiter, Daniel;
Pichler, Martin;
Di Fazio, Pietro

Publication type:

Article

The Hedgehog inhibitor cyclopamine impairs the benefits of immunotherapy with activated T and NK lymphocytes derived from patients with advanced cancer.

Published in:

Cancer Immunology, Immunotherapy, 2013, v. 62, n. 6, p. 1029, doi. 10.1007/s00262-013-1419-5

By:

Onishi, Hideya;
Morisaki, Takashi;
Kiyota, Akifumi;
Koya, Norihiro;
Tanaka, Hiroto;
Umebayashi, Masayo;
Katano, Mitsuo

Publication type:

Article

Down-regulation of specific miRNAs enhances the expression of the gene Smoothened and contributes to T-cell lymphoblastic lymphoma development.

Published in:

Carcinogenesis, 2013, v. 34, n. 4, p. 902

By:

González-Gugel, Elena;
Villa-Morales, María;
Santos, Javier;
Bueno, Maria José;
Malumbres, Marcos;
Rodríguez-Pinilla, Socorro María;
Piris, Miguel Ángel;
Fernández-Piqueras, José

Publication type:

Article

Molecular Characterization of the Hedgehog Signaling Pathway and Its Necessary Function on Larval Myogenesis in the Pacific Oyster Crassostrea gigas.

Published in:

Frontiers in Physiology, 2018, p. N.PAG, doi. 10.3389/fphys.2018.01536

By:

Li, Huijuan;
Li, Qi;
Yu, Hong

Publication type:

Article

Shh Signaling through the Primary Cilium Modulates Rat Oligodendrocyte Differentiation.

Published in:

PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0133567

By:

Falcón-Urrutia, Paulina;
Carrasco, Carlos M.;
Lois, Pablo;
Palma, Veronica;
Roth, Alejandro D.

Publication type:

Article

Combination of Cyclopamine and Tamoxifen Promotes Survival and Migration of MCF-7 Breast Cancer Cells – Interaction of Hedgehog-Gli and Estrogen Receptor Signaling Pathways.

Published in:

PLoS ONE, 2014, v. 9, n. 12, p. 1, doi. 10.1371/journal.pone.0114510

By:

Sabol, Maja;
Trnski, Diana;
Uzarevic, Zvonimir;
Ozretic, Petar;
Musani, Vesna;
Rafaj, Maja;
Cindric, Mario;
Levanat, Sonja

Publication type:

Article

Impact of the Smoothened Inhibitor, IPI-926, on Smoothened Ciliary Localization and Hedgehog Pathway Activity.

Published in:

PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0090534

By:

Peluso, Marisa O.;
Campbell, Veronica T.;
Harari, Joseph A.;
Tibbitts, Thomas T.;
Proctor, Jennifer L.;
Whitebread, Nigel;
Conley, James M.;
White, Kerry F.;
Kutok, Jeffery L.;
Read, Margaret A.;
McGovern, Karen;
Faia, Kerrie L.

Publication type:

Article

Irradiated Riboflavin Diminishes the Aggressiveness of Melanoma In Vitroand In Vivo.

Published in:

PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0054269

By:

Machado, Daisy;
Shishido, Silvia M.;
Queiroz, Karla C. S.;
Oliveira, Diogo N.;
Faria, Ana L. C.;
Catharino, Rodrigo R.;
Spek, C. Arnold;
Ferreira, Carmen V.

Publication type:

Article

Sonic Hedgehog-Signalling Patterns the Developing Chicken Comb as Revealed by Exploration of the Peacomb Mutation.

Published in:

PLoS ONE, 2012, v. 7, n. 12, p. 1, doi. 10.1371/journal.pone.0050890

By:

Boije, Henrik;
Harun-Or-Rashid, Mohammad;
Yu-Jen Lee;
Imsland, Freyja;
Bruneau, Nicolas;
Vieaud, Agathe;
Gourichon, David;
Tixier-Boichard, Michèle;
Bed'hom, Bertrand;
Andersson, Leif;
Hallböök, Finn

Publication type:

Article

Hedgehog Pathway Signaling Regulates Human Colon Carcinoma HT-29 Epithelial Cell Line Apoptosis and Cytokine Secretion.

Published in:

PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0045332

By:

Yoshimoto, Agnes N.;
Bernardazzi, Claudio;
Carneiro, Antonio José V.;
Elia, Celeste C. S.;
Martinusso, Cesonia A.;
Ventura, Grasiella M.;
Castelo-Branco, Morgana T. L.;
De Souza, Heitor S. P.;
Katoh, Masaru

Publication type:

Article

Tissue Plasminogen Activator and Plasminogen Activator Inhibitor 1 Contribute to Sonic Hedgehog-Induced In Vitro Cerebral Angiogenesis.

Published in:

PLoS ONE, 2012, v. 7, n. 3, p. 1, doi. 10.1371/journal.pone.0033444

By:

Teng, Hua;
Chopp, Michael;
Hozeska-Solgot, Ann;
Shen, Lihong;
Lu, Mei;
Tang, Clark;
Zhang, Zheng Gang

Publication type:

Article

Inhibition of Hedgehog Signaling Antagonizes Serous Ovarian Cancer Growth in a Primary Xenograft Model.

Published in:

PLoS ONE, 2011, v. 6, n. 11, p. 1, doi. 10.1371/journal.pone.0028077

By:

McCann, Christopher K.;
Growdon, Whitfield B.;
Kulkarni-Datar, Kashmira;
Curley, Michael D.;
Friel, Anne M.;
Proctor, Jennifer L.;
Sheikh, Hana;
Deyneko, Igor;
Ferguson, Jeanne A.;
Vathipadiekal, Vinod;
Birrer, Michael J.;
Borger, Darrell R.;
Mohapatra, Gayatry;
Zukerberg, Lawrence R.;
Foster, Rosemary;
MacDougall, John R.;
Rueda, Bo R.

Publication type:

Article

Expression of DNMT1 and DNMT3a Are Regulated by GLI1 in Human Pancreatic Cancer.

Published in:

PLoS ONE, 2011, v. 6, n. 11, p. 1, doi. 10.1371/journal.pone.0027684

By:

ShanShan He;
Feng Wang;
LiJuan Yang;
ChuanYong Guo;
Rong Wan;
AiWu Ke;
Ling Xu;
GuoYong Hu;
XuanFu Xu;
Jie Shen;
XingPeng Wang

Publication type:

Article

Sonic Hedgehog Pathway Is Essential for Maintenance of Cancer Stem-Like Cells in Human Gastric Cancer.

Published in:

PLoS ONE, 2011, v. 6, n. 3, p. 1, doi. 10.1371/journal.pone.0017687

By:

Zhou Song;
Wen Yue;
Bo Wei;
Ning Wang;
Tao Li;
Lidong Guan;
Shuangshuang Shi;
Quan Zeng;
Xuetao Pei;
Lin Chen

Publication type:

Article

Cyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cells.

Published in:

2016

By:

Alam, Md Maksudul;
Sohoni, Sagar;
Kalainayakan, Sarada Preeta;
Garrossian, Massoud;
Li Zhang;
Zhang, Li

Publication type:

journal article

The Effect of Pancreas Islet-Releasing Factors on the Direction of Embryonic Stem Cells Towards Pdx1 Expressing Cells.

Published in:

Applied Biochemistry & Biotechnology, 2018, v. 186, n. 2, p. 371, doi. 10.1007/s12010-018-2733-3

By:

Elham, Hoveizi;
Mahmoud, Hashemitabar

Publication type:

Article

Hypoxia Accelerates Aggressiveness of Hepatocellular Carcinoma Cells Involving Oxidative Stress, Epithelial-Mesenchymal Transition and Non-Canonical Hedgehog Signaling.

Published in:

Cellular Physiology & Biochemistry (Karger AG), 2017, v. 44, n. 5, p. 1856, doi. 10.1159/000485821

By:

Liu, Zhikui;
Tu, Kangsheng;
Wang, Yufeng;
Yao, Bowen;
Li, Qing;
Wang, Liang;
Dou, Changwei;
Liu, Qingguang;
Zheng, Xin

Publication type:

Article

Protective Effects of Sonic Hedgehog Against Ischemia/Reperfusion Injury in Mouse Skeletal Muscle via AKT/mTOR/p70S6K Signaling.

Published in:

Cellular Physiology & Biochemistry (Karger AG), 2017, v. 43, n. 5, p. 1813, doi. 10.1159/000484068

By:

Zeng, Qiu;
Fu, Qining;
Wang, Xuehu;
Zhao, Yu;
Liu, Hong;
Li, Zhui;
Li, Fenghe

Publication type:

Article

Resveratrol Enhances Neurite Outgrowth and Synaptogenesis Via Sonic Hedgehog Signaling Following Oxygen-Glucose Deprivation/Reoxygenation Injury.

Published in:

Cellular Physiology & Biochemistry (Karger AG), 2017, v. 43, n. 2, p. 852, doi. 10.1159/000481611

By:

Tang, Fanren;
Guo, Shuang;
Liao, Hongyan;
Yu, Pingping;
Wang, Li;
Song, Xiaosong;
Chen, Jixiang;
Yang, Qin

Publication type:

Article

Baicalin Attenuates Alcoholic Liver Injury through Modulation of Hepatic Oxidative Stress, Inflammation and Sonic Hedgehog Pathway in Rats.

Published in:

Cellular Physiology & Biochemistry (Karger AG), 2016, v. 39, n. 3, p. 1129, doi. 10.1159/000447820

By:

Wang, Huifen;
Zhang, Yanli;
Bai, Ruxue;
Wang, Miao;
Du, Shiyu

Publication type:

Article

Relationship between Hedgehog Signaling Pathway and Drug Resistance of Poorly Differentiated Gliomas.

Published in:

Bulletin of Experimental Biology & Medicine, 2018, v. 164, n. 3, p. 356, doi. 10.1007/s10517-018-3989-x

By:

Cherepanov, S.;
Grinenko, N.;
Antonova, O.;
Kurapov, P.;
Shepeleva, I.;
Chekhonin, V.

Publication type:

Article

Effect of Hedgehog Signaling Pathway Activation on Proliferation of High-Grade Gliomas.

Published in:

Bulletin of Experimental Biology & Medicine, 2016, v. 161, n. 5, p. 674, doi. 10.1007/s10517-016-3483-2

By:

Cherepanov, S.;
Cherepanova, K.;
Grinenko, N.;
Antonova, O.;
Chekhonin, V.

Publication type:

Article

Establishing clones of Veratrum californicum, a native medicinal species, for micropropagation.

Published in:

In Vitro Cellular & Developmental Biology Plant, 2014, v. 50, n. 3, p. 337, doi. 10.1007/s11627-014-9603-7

By:

Song, Ju;
Naylor-Adelberg, Jacqueline;
White, Sarah;
Mann, David;
Adelberg, Jeffrey

Publication type:

Article

Inhibition of early development stages of rust fungi by the two fungal metabolites cyclopaldic acid and epi-epoformin.

Published in:

Pest Management Science, 2017, v. 73, n. 6, p. 1161, doi. 10.1002/ps.4438

By:

Barilli, Eleonora;
Cimmino, Alessio;
Masi, Marco;
Evidente, Marco;
Rubiales, Diego;
Evidente, Antonio

Publication type:

Article

Cyclopamine treatment disrupts extracellular matrix and alleviates solid stress to improve nanomedicine delivery for pancreatic cancer.

Published in:

Journal of Drug Targeting, 2018, v. 26, n. 10, p. 913, doi. 10.1080/1061186X.2018.1452243

By:

Zhang, Bo;
Wang, Honglan;
Jiang, Ting;
Jin, Kai;
Luo, Zimiao;
Shi, Wei;
Mei, Heng;
Wang, Huafang;
Hu, Yu;
Pang, Zhiqing;
Jiang, Xinguo

Publication type:

Article

Attenuation of early liver fibrosis by pharmacological inhibition of smoothened receptor signaling.

Published in:

Journal of Drug Targeting, 2012, v. 20, n. 9, p. 770, doi. 10.3109/1061186X.2012.719900

By:

Pratap, Akshay;
Singh, Saurabh;
Mundra, Vaibhav;
Yang, Ningning;
Panakanti, Ravikiran;
Eason, James D.;
Mahato, Ram I.

Publication type:

Article

Sonic Hedgehog inhibition as a strategy to augment radiosensitivity of hepatocellular carcinoma.

Published in:

Journal of Gastroenterology & Hepatology, 2015, v. 30, n. 8, p. 1317, doi. 10.1111/jgh.12931

By:

Tsai, Chiao‐Ling;
Hsu, Feng‐Ming;
Tzen, Kai‐Yuan;
Liu, Wei‐Lin;
Cheng, Ann‐Lii;
Cheng, Jason Chia‐Hsien

Publication type:

Article

Cyclopamine-Paclitaxel-Containing Nanoparticles: Internalization in Cells Detected by Confocal and Super-Resolution Microscopy.

Published in:

ChemPlusChem, 2015, v. 80, n. 9, p. 1380, doi. 10.1002/cplu.201500156

By:

Fumagalli, Gaia;
Mazza, Davide;
Christodoulou, Michael S.;
Damia, Giovanna;
Ricci, Francesca;
Perdicchia, Dario;
Stella, Barbara;
Dosio, Franco;
Sotiropoulou, Panagiota A.;
Passarella, Daniele

Publication type:

Article

Sonic Hedgehog Promotes Neurite Outgrowth of Primary Cortical Neurons Through Up-Regulating BDNF Expression.

Published in:

Neurochemical Research, 2016, v. 41, n. 4, p. 687, doi. 10.1007/s11064-015-1736-5

By:

He, Weiliang;
Cui, Lili;
Zhang, Cong;
Zhang, Xiangjian;
He, Junna;
Xie, Yanzhao

Publication type:

Article

The sonic hedgehog pathway mediates brain plasticity and subsequent functional recovery after bone marrow stromal cell treatment of stroke in mice.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2013, v. 33, n. 7, p. 1015, doi. 10.1038/jcbfm.2013.50

By:

Ding, Xiaoshuang;
Li, Yi;
Liu, Zhongwu;
Zhang, Jing;
Cui, Yisheng;
Chen, Xiaoguang;
Chopp, Michael

Publication type:

Article

The combined effect of <italic>Pdx1</italic> overexpression and Shh manipulation on the function of insulin‐producing cells derived from adipose‐tissue stem cells.

Published in:

FEBS Open Bio, 2018, v. 8, n. 3, p. 372, doi. 10.1002/2211-5463.12378

By:

Hashemi Tabar, Mahmoud;
Tabandeh, Mohammad Reza;
Moghimipour, Eskandar;
Dayer, Dian;
Ghadiri, Ata A.;
Allah Bakhshi, Elham;
Orazizadeh, Mahmoud;
Ghafari, Mohammad Ali

Publication type:

Article

Activation of sonic hedgehog signaling enhances cell migration and invasion by induction of matrix metalloproteinase-2 and -9 via the phosphoinositide-3 kinase/AKT signaling pathway in glioblastoma.

Published in:

Molecular Medicine Reports, 2015, v. 12, n. 5, p. 6702, doi. 10.3892/mmr.2015.4229

By:

LIANG CHANG;
DAN ZHAO;
HUI-BIN LIU;
QIU-SHI WANG;
PING ZHANG;
CHEN-LONG LI;
WEN-ZHONG DU;
HONG-JUN WANG;
XING LIU;
ZHI-REN ZHANG;
CHUAN-LU JIANG

Publication type:

Article

Inhibitory Potential of Postnatal Treatment with Cyclopamine, a Hedgehog Signaling Inhibitor, on Medulloblastoma Development in Ptch1 Heterozygous Mice.

Published in:

Toxicologic Pathology, 2014, v. 42, n. 8, p. 1174, doi. 10.1177/0192623314530194

By:

Matsuo, Saori;
Takahashi, Miwa;
Inoue, Kaoru;
Tamura, Kei;
Irie, Kaoru;
Kodama, Yukio;
Nishikawa, Akiyoshi;
Yoshida, Midori

Publication type:

Article

Liver kinase B1 suppresses growth of lung cancer cells through sonic hedgehog signaling pathway.

Published in:

Cell Biology International, 2018, v. 42, n. 8, p. 994, doi. 10.1002/cbin.10965

By:

Song, Kuiyuan;
Zheng, Guanqun;
Zhao, Yue

Publication type:

Article

mTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions.

Published in:

Scientific Reports, 2013, p. 1, doi. 10.1038/srep03230

By:

Shyuichiro Matsubara;
Qiang Ding;
Yumi Miyazaki;
Taisaku Kuwahata;
Koichiro Tsukasa;
Sonshin Takao

Publication type:

Article

A partial synthesis of 23-hydroxybetulonic acid and 23-hydroxybetulinic acid starting from betulinic acid.

Published in:

Journal of Chemical Research, 2012, v. 36, n. 5, p. 254, doi. 10.3184/174751912X13332875186150

By:

Sun, Fei;
Zhu, Peiqing;
Yao, Hequan;
Wu, Xiaoming;
Xu, Jinyi

Publication type:

Article

Sonic hedgehog signaling regulates mode of cell division of early cerebral cortex progenitors and increases astrogliogenesis.

Published in:

Frontiers in Cellular Neuroscience, 2014, v. 8, p. 1, doi. 10.3389/fncel.2014.00077

By:

Araújo, Geissy L. L.;
Araújo, Jessica A. M.;
Schroeder, Timm;
Tort, Adriano B. L.;
Costa, Marcos R.

Publication type:

Article

Clobetasol Modulates Adult Neural Stem Cell Growth via Canonical Hedgehog Pathway Activation.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 8, p. 1991, doi. 10.3390/ijms20081991

By:

Vicario, Nunzio;
Bernstock, Joshua D.;
Spitale, Federica M.;
Giallongo, Cesarina;
Giunta, Maria A.S.;
Li Volti, Giovanni;
Gulisano, Massimo;
Leanza, Giampiero;
Tibullo, Daniele;
Parenti, Rosalba;
Gulino, Rosario

Publication type:

Article

The Effects of Inhibiting Hedgehog Signaling Pathways by Using Specific Antagonist Cyclopamine on the Chondrogenic Differentiation of Mesenchymal Stem Cells.

Published in:

International Journal of Molecular Sciences, 2013, v. 14, n. 3, p. 5966, doi. 10.3390/ijms14035966

By:

Xing Wu;
Zheng-Dong Cai;
Lei-Ming Lou;
Zheng-Rong Chen

Publication type:

Article

Trophic and proliferative effects of Shh on motor neurons in embryonic spinal cord culture from wildtype and G93A SOD1 mice.

Published in:

BMC Neuroscience, 2013, v. 14, n. 1, p. 1, doi. 10.1186/1471-2202-14-119

By:

Xiaoxing Ma;
Patrick Turnbull;
Randy Peterson;
John Turnbull

Publication type:

Article

Sonic hedgehog (Shh)/Gli modulates the spatial organization of neuroepithelial cell proliferation in the developing chick optic tectum.

Published in:

BMC Neuroscience, 2012, v. 13, n. 1, p. 1, doi. 10.1186/1471-2202-13-117

By:

Rapacioli, Melina;
Botelho, Joao;
Cerda, Gustavo;
Duarte, Santiago;
Elliot, Matías;
Palma, Verónica;
Flores, Vladimir

Publication type:

Article

Therapeutic Targeting of the Myeloma Stem Cell.

Published in:

Current Medical Literature: Leukemia & Lymphoma, 2013, v. 21, n. 2, p. 37

By:

Vicente-Dueñas, Carolina;
Sánchez-García, Isidro

Publication type:

Article

Native V. californicum Alkaloid Combinations Induce Differential Inhibition of Sonic Hedgehog Signaling.

Published in:

Molecules, 2018, v. 23, n. 9, p. 2222, doi. 10.3390/molecules23092222

By:

Turner, Matthew W.;
Cruz, Roberto;
Elwell, Jordan;
French, John;
Mattos, Jared;
McDougal, Owen M.

Publication type:

Article