Antimicrobial and Antibiofilm Activity of D-amino acids Combined with Nanoparticles against Candida albicans.

Jasim, Saif Talib; Noori, Asoda Mohammed; Sadiq, Shadman Tariq; Flayyih, May Talib

For the examined acids of D-amino, our findings indicated that Daspartic (D-asp) acid was of high antifungal potentential, and then Dglycine. Also, the current study aimed to determine the effects of Damino acids and nanoparticles against Candida albicans adhered cells and biofilms, results illustrated the D-asp concentration of 50 μg /ml caused inhibition as the highest, whereas the least was of D-gly 100 μg /ml of against mature bio-film cell adhesion and. The results proved that the combination of amino acid (D-glycine and D-aspartic acid) and nanoparticles (silver and lithium) at sub MIC concentrations (p≤0.05) inhibited cell adhesion and mature biofilm. Scanning electron microscope (SEM) results in observing the structure consisted of biofilm isolate C.albicans revealed, whereas therapy of D-asp had an effect on bio-film layers of more losing loss in the layers merged of bio-film and destroyed it. On the other hand, merged lithium along the D-asp effect destroyed cells and caused the bio-film single layer survival.

Systematic Reviews in Pharmacy, 2020, Vol 11, Issue 5, p274

0975-8453

Academic Journal

10.31838/srp.2020.5.40