Hepatoprotective activity and molecular docking studies of Chloroxylon swietenia DC. fruit extract phytocompounds.

B., RAVISHANKARA; MAHMOOD, RIAZ; KRISHNA, V.; N. M., VINAYKUMAR; SHASTRI, SUDHESH L.

Chloroxylon swietenia DC. is a folklore medicinal plant that belongs to the family Rutaceae is known as 'East Indian satinwood' or 'Cylon satinwood' native to South India and Sri Lanka. Almost all parts of this plant are being used in the indigenous system of medicine for a long time. The invitro antioxidant activity screening of fruit petroleum ether, chloroform and ethanol extracts confirms that the fruit ethanol extract is stronger among the extracts tested. Therefore, this extract was considered further for invivo studies. In vivo, acute toxicity study of ethanol extract via oral administration indicated that it is non -toxic in a dose-dependent manner. This is revealed by morphological observation of no mortality and morbidity in experimental animals after completing 14 days of the experimental period. Further, the GC-MS identified phytocompounds of fruit ethanol extract from Chloroxylon swietenia DC were studied against CCl4 induced liver toxicity in Swiss albino rats. The activity was assessed by monitoring various parameters of serum marker enzyme activity such as Alanine transaminase (ALT), Aspartate transaminase (AST), Alkaline phosphatase (ALP), and liver tissue architecture. In silico ADMET studies and docking techniques were carried out to authenticate the drug likeliness. The results from the invivo and insilico studies have revealed that the fruit ethanol extract of Chloroxylon swietenia DC could be useful in preventing CCl4 induced liver toxicity.

MOLECULAR docking; PHYTOCHEMICALS; MEDICINAL plants; ANTIOXIDANT analysis; HEPATOTOXICOLOGY

International Journal of Pharmaceutical Research (09752366), 2021, Vol 13, Issue 2, p2704

0975-2366

Academic Journal

10.31838/ijpr/2021.13.02.377