Application of stearic acid in organogel as a floating system.

KADDOORI, ZAINAB SAAD; MOHAMED, MASAR BASIM MOHSIN; NUMAN, NAWFAL AM.; AL-FALAHI, NADIA HAMEED RIJA

Stearic acid in sesame oil prepared in three different concentrations which were: 7%, 10% and 15% w/w SA/SO as organogel and Cinnarizine (CN) was loaded as a model drug for its advantageous physical and chemical properties. The aim of the work was firstly, detection of floating properties for organogel which are floating lag time and floating duration. Secondly, detections of organogel properties which starting with the thermal behavior by table top rheology study, rheological properties via oscillatory amplitude sweep test and probing the organogel network morphology with an optical microscope. Furthermore, the assembly of gelators was investigated by Fourier-transform infrared spectroscopy (FTIR), this was followed by in-vitro release and invivo floating studies. The floating properties of the 15% w/w SA/SO organogel whether being liquid or solid was the zero of the lag time and the floating duration was 24 hours as well as the transition temperature was reversible that showed stability in 37 °C. Also, optical images showed fibrillar scaffold and the fiber length decreased when the concentration of gelator increased. Also, FTIR showed that the hydrogen bonds could be involved in scaffold construction by making gelator-gelator interactions as a shift in the peaks that associated with the carbonyl group was noticed. Moreover, organogels viscoelastic properties showed G' larger than G" and increase of both values as the concentration of SA increased. Lastly, the 15%w/w SA/SO slowed the release of CN and SA/SO organogel was retained in the rat's stomach for 12 hours.

STEARIC acid; SESAME oil; CARBONYL group; RHEOLOGY; TRANSITION temperature; OPTICAL microscopes; SALICYLIC acid

International Journal of Pharmaceutical Research (09752366), 2020, p1832

0975-2366

Academic Journal

10.31838/ijpr/2020.SP1.280