Comparison of Biopyrrin, Bilirubin and Creatinine in Neonatal Jaundice in Al-Najaf City, Iraq.

ALJAZAERI, SARAH ALI

Background: Neonatal jaundice (hyperbilirubinemia) is a higher than-normal level of bilirubin in the blood. Bilirubin is a by-product of the breakdown of red blood cells. Methods: This study was designed to investigate biopyrrin and creatinine levels and their relationship with increasing level of total serum bilirubin for neonates infected by hyperbilirubinemia, as well as find a relationship between the above criteria in both male and female. In this study sixty neonatal patients suffering from hyperbilirubinemia (35 males, 25females) where they were admitted to the prematurity unit (PU) in Al-Najaf Al-Ashraf during the period from August, 2019 to February, 2020. A group of 20 randomly (12 males, 8 females) selected apparently healthy group. Results: The results of the study show a significant increase (p<0.05) in serum levels of biopyrrin, bilirubin and creatinine in neonatal with hyperbilirubinemia as compared with healthy group. The results of the study also reveal no significant differences (p<0.05) in serum levels of biopyrrin, between males and females, while shows a significant increase (p<0.05) in serum levels of bilirubin and creatinine in male when compared with female. Conclusions: Biopyrrin is important as biomarker in the detection and diagnosis of neonatal hyperbilirubinemia. High level of biopyrrin is involved in kidney dysfunction, initiation and progression of neonatal hyperbilirubinemia. There is a relationship between age and the high level of biomarkers as a result of severe systemic damage.

IRAQ; NAJAF (Iraq); NEONATAL jaundice; BILIRUBIN; CREATININE; ERYTHROCYTES

International Journal of Pharmaceutical Research (09752366), 2020, p841

0975-2366

Academic Journal

10.31838/ijpr/2020.SP1.132