The Effect of Carbofuran Exposure on Mice During Lactation Period Against on Histopathology Description of The Heart of Mice (Mus Musculus) Offspring.

ASRIANTI, AISYAH; WIDJIATI; LEGOWO, DJOKO; MASLACHAH, LILIK; ARIMBI; LUQMAN, EPY MUHAMMAD

Carbofuran exposure has been reported to be able to induce reactive oxygen species or free radicals in the heart that cause oxidative stress. In the present study of carbofuran induced increase heart damage in histophatological analysis of mice heart. Aim: this study was to evaluate the effect of carbofuran exposure during lactation period on heart histopathological of mice offspring. Adult in lactation period BABLB/C were randomly divided into four treatment groups. Group K as control were given distilled water, group P1 were given carbofuran 1/16 LD50 (=0.3125 mg/kg), P2 1/8 LD50 (=0.625 mg/kg), and P3 1/4 LD50 (=1.25 mg/kg) for nine days from first day their offspring born. Twenty offspring were randomly selected each treatment group. On the ten day of experimental offspring dissected and the heart organ was taken to made histophatology sample. Samples were compared and the results showed a significant increase in the degree of cardiac damage between K, P1, P2, and P3. Results, carbofuran caused increased group P1 suffered heart damage as much as 9.28 including minor damage, group P2 suffered heart damage as much as 12.56 including moderate damage, and group P3 suffered heart damage as much as 18.04 including severe damage. Conclusion, carbofuran exposure in heart cells triggers histopathological damage to heart organs such as inflammatory cells, degeneration, necrosis, and congestion as the dose is increased.

CARBOFURAN; MICE; REACTIVE oxygen species; OXIDATIVE stress; HEART failure; LACTATION; HEART cells

International Journal of Pharmaceutical Research (09752366), 2020, Vol 12, Issue 4, p4674

0975-2366

Academic Journal

10.31838/ijpr/2020.12.04.327