Title: POTENTIAL PROCESS RELATED SUBSTANCE OF ATORVASTATIN CALCIUM: IDENTIFICATION, SYNTHESIS AND SPECTRAL CHARACTERIZATION INCLUDING CONTROL STRATEGY.
Authors: Gutta, Madhusudhan; Chakradhar, Nandigama; Kotte, Chandramohan; Kokkula, Kishore; Mittapelli, Vasantha
Abstract: HPLC analysis of Atorvastatin Calcium showed an unknown compound peak, the sample was also analyzed by LCMS and the corresponding peak was identified at m/z 854.06. The pure compound was prepared individually and characterized. The compound structure was assigned as tert-butyl 2-((4R,6R)-6-(2-(2-((4R,6R)-6-(2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrol-1-yl]-ethyl)-2,2-dimethyl-1,3-dioxan-4- yl)acetamido)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate.
Subjects: ATORVASTATIN; CALCIUM; HIGH performance liquid chromatography; CONDENSATION; ACETATES
Publication: Rasayan Journal of Chemistry, 2024, Vol 17, Issue 4, p1573
ISSN: 0974-1496
Publication type: Academic Journal
DOI: 10.31788/RJC.2024.1748984

POTENTIAL PROCESS RELATED SUBSTANCE OF ATORVASTATIN CALCIUM: IDENTIFICATION, SYNTHESIS AND SPECTRAL CHARACTERIZATION INCLUDING CONTROL STRATEGY.

Gutta, Madhusudhan; Chakradhar, Nandigama; Kotte, Chandramohan; Kokkula, Kishore; Mittapelli, Vasantha