Results
Title

SOLVENT-FREE SYNTHESIS OF 4'-HYDROXY-4-HYDROXY CHALCONE AND ITS POTENTIAL AS AN ANTIBACTERIAL.

Authors

Elfi Susanti, V. H.; Mulyani, S.; S. R. D., Ariani; Utomo, Suryadi Budi; Wathon, Muhammad Hizbul

Abstract

This study aimed to synthesize 4'-hydroxy-4-hydroxy chalcone from 4-hydroxy acetophenone and 4- hydroxybenzaldehyde by a solvent-free method using a grinding technique and determine its potential as an antibacterial against Staphylococcus aureus and Escherichia coli. Synthesis of 4'-hydroxy-4-hydroxy chalcone was conducted using the Claisen-Schmidt method of grinding for 30 minutes. The grinding results were then extracted with chloroform. The formed crystals were tested for purity by thin-layer chromatography (TLC), and recrystallization was carried out to purify the compound. FTIR, ¹H-NMR, and 13C-NMR characterized the synthesized chalcone. The synthesized chalcone was determined for antibacterial activity using the disc method against Staphylococcus aureus and Escherichia coli. The results showed that 4'-hydroxy-4-hydroxy chalcone could be synthesized from 4-hydroxy acetophenone and 4-hydroxy benzaldehyde by grinding technique in orangish white crystals form (yield of 66.67%) and a melting point of 85-88°C. The synthesized chalcone has low antibacterial potential against Staphylococcus aureus and Escherichia coli.

Subjects

MELTING points; STAPHYLOCOCCUS aureus; ESCHERICHIA coli; RECRYSTALLIZATION (Metallurgy); ACETOPHENONE; CHALCONE

Publication

Rasayan Journal of Chemistry, 2024, Vol 17, Issue 4, p1604

ISSN

0974-1496

Publication type

Academic Journal

DOI

10.31788/RJC.2024.1748889