Results
Title

FLAVONOID GLYCOSIDE COMPOUND FROM TOMBILI SEED (Caesalpinia bonducella) AND ITS ANTIOXIDANT ACTIVITY.

Authors

Musa, Weny J. A.; Bialangi, Nurhayati; Kilo, Ahmad Kadir; Lamangantjo, C. J.; Situmeang, Boima; Ibrahim, Agus Malik

Abstract

Caesalpinia bonducella, known as ‘tombili’ belongs to the family of Fabaceae. Tombili has been empirically used as traditional medicine. In a previous study, phytochemical screening showed that tombili seed contained alkaloid, flavonoid, terpenoid, and tannin compounds. This research aimed to isolate an antioxidant compound from tombili seed extract. Fractionated using n-hexane, ethyl acetate, and methanol as a solvent. All fractions were tested for their antioxidant potential. The ethyl acetate fraction gave a better antioxidant potential (IC50 86.153±4.22 ppm) than it has purified. Characterization of an isolated compound using various spectroscopies data, including UV, FTIR, 1D-NMR, 2D-NMR, and LCMS/MS. The structure of the isolated compound was suggested as 7- (β-DGlucopyranosyloxy) 5-hydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one (homoplantaginin). The IC50 value of the isolated compound was 40.53 ±3.13 ppm, indicating the isolated compound has potent antioxidant activity.

Subjects

FLAVONOIDS; CAESALPINIA; PHYTOCHEMICALS; ETHYL acetate; SEEDS; ANTIOXIDANT testing; GLYCOSIDES; LEGUMES; FLAVONOID glycosides

Publication

Rasayan Journal of Chemistry, 2022, Vol 15, Issue 4, p2237

ISSN

0974-1496

Publication type

Academic Journal

DOI

10.31788/RJC.2022.1547087