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Title: Synthesis and leishmanicidal activity of 2,3,4-substituted-5-imidazolones.
Authors: Khan, Khalid Mohammed; Mughal, Uzma Rasool; Ambreen, Nida; Samreen; Perveen, Shahnaz; Choudhary, M. Iqbal
Abstract: Twenty-nine imidazolones 1–29 were synthesized and were randomly screened for their in vitro anti-leishmanial potential. Compound 17 showed a good anti-leishmanial activity with an IC50 value of 12.98 ± 0.32 μg/mL. Compounds 14 and 24 were also found to be moderately active (IC50 values 28.20 ± 0.03 and 41.12 ± 0.32 μg/mL, respectively). The activity was compared with that of standard drugs, amphotericin B (IC50 = 0.12 ± 0.41 μg/mL) and pentamidine (IC50 = 2.56 ± 0.10 μg/mL).
Subjects: LEISHMANIA; AMPHOTERICIN B; IONOPHORES; POLYENE antibiotics; PHARMACODYNAMICS
Publication: Journal of Enzyme Inhibition & Medicinal Chemistry, 2010, Vol 25, Issue 1, p29
ISSN: 1475-6366
Publication type: Academic Journal
DOI: 10.3109/14756360902932768

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Synthesis and leishmanicidal activity of 2,3,4-substituted-5-imidazolones.