Title: Genetic polymorphisms of XRCC1 gene and susceptibility to gastric cancer in Chinese Han population.
Authors: Lu, Zhengmao; Luo, Tianhang; Nie, Mingming; Bi, Jianwei; Ke, Chongwei; Xue, Xuchao; Ma, Liye; Fang, Guoen
Abstract: This study aims to evaluate whether the c.1471G>A and c.1686C>G genetic polymorphisms of XRCC1 gene influencing gastric cancer susceptibility. A total of 813 subjects with Chinese Han ethnicity were enrolled. Our data suggest that the allele and genotype frequencies are significantly different from gastric cancer patients with cancer-free controls. We find that c.1471G>A and c.1686C>G genetic polymorphisms statistically increase the risk of gastric cancer. Our findings indicate these two genetic polymorphisms are related with the susceptibility to gastric cancer, and could be used as molecular markers for detecting gastric cancer in Chinese Han ethnicity.
Subjects: STOMACH cancer; GENETIC polymorphism research; CHINESE people; GENETICS of disease susceptibility; CANCER risk factors research; CANCER genetics; DISEASES
Publication: Biomarkers, 2013, Vol 18, Issue 6, p542
ISSN: 1354-750X
Publication type: Academic Journal
DOI: 10.3109/1354750X.2013.822562

Genetic polymorphisms of XRCC1 gene and susceptibility to gastric cancer in Chinese Han population.

Lu, Zhengmao; Luo, Tianhang; Nie, Mingming; Bi, Jianwei; Ke, Chongwei; Xue, Xuchao; Ma, Liye; Fang, Guoen