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- Title
Genetic polymorphisms of XRCC1 gene and susceptibility to gastric cancer in Chinese Han population.
- Authors
Lu, Zhengmao; Luo, Tianhang; Nie, Mingming; Bi, Jianwei; Ke, Chongwei; Xue, Xuchao; Ma, Liye; Fang, Guoen
- Abstract
This study aims to evaluate whether the c.1471G>A and c.1686C>G genetic polymorphisms of XRCC1 gene influencing gastric cancer susceptibility. A total of 813 subjects with Chinese Han ethnicity were enrolled. Our data suggest that the allele and genotype frequencies are significantly different from gastric cancer patients with cancer-free controls. We find that c.1471G>A and c.1686C>G genetic polymorphisms statistically increase the risk of gastric cancer. Our findings indicate these two genetic polymorphisms are related with the susceptibility to gastric cancer, and could be used as molecular markers for detecting gastric cancer in Chinese Han ethnicity.
- Subjects
STOMACH cancer; GENETIC polymorphism research; CHINESE people; GENETICS of disease susceptibility; CANCER risk factors research; CANCER genetics; DISEASES
- Publication
Biomarkers, 2013, Vol 18, Issue 6, p542
- ISSN
1354-750X
- Publication type
Academic Journal
- DOI
10.3109/1354750X.2013.822562