Roll compaction/dry granulation: Comparison between roll mill and oscillating granulator in dry granulation.

Sakwanichol, Jarunee; Puttipipatkhachorn, Satit; Ingenerf, Gernot; Kleinebudde, Peter

Different experimental factorial designs were employed to evaluate granule properties obtained from oscillating granulator and roll mill. Four oscillating-granulator parameters were varied, i.e. rotor speed, oscillating angle, aperture of mesh screen and rotor type. Six roll-mill parameters that were throughput, speed ratio in both first and second stages, gap between roll pair in both stages and roll-surface texture were also investigated. Afterwards, the granule properties obtained from two milling types with similar median particle size were compared. All milling parameters in both milling types affected significantly the median particle size, size distribution and amount of fine particles ( P < 0.05), except the rotor types of oscillating granulator on fines. Only three milling parameters influenced significantly the flowability ( P < 0.05). These were the throughput and the gap size in the first stage of roll mill and the sieve size of oscillating granulator. In comparison between milling types, the differences of granule properties were not practically relevant. However, the roll mill had much higher capacity than the oscillating granulator about seven times, resulting in improving energy savings per unit of product. Consequently, the roll mill can be applied instead of oscillating granulator for roll compaction/dry granulation technique.

DRUG granulation; ROLL compacting; FACTORIAL experiment designs; PARTICLE size distribution; COMPARATIVE studies; ENERGY conservation

Pharmaceutical Development & Technology, 2012, Vol 17, Issue 1, p30

1083-7450

Academic Journal

10.3109/10837450.2010.508078