Relationship between uric acid and metabolic syndrome according to menopausal status.

Lee, Hee Jung; Park, Hyun Tae; Cho, Geum Joon; Yi, Kyung Wook; Ahn, Ki Hoon; Shin, Jung-Ho; Kim, Tak; Kim, Young Tae; Hur, Jun Young; Kim, Sun Haeng

Objective. Uric acid, the levels of which have been shown to increase after menopause, has been associated with metabolic syndrome. The prevalence of metabolic syndrome has also been determined to increase after menopause. Therefore, we surmised that menopausal status-specific analyses for the characterisation of the relationship between uric acid and the metabolic syndrome were warranted. Methods. We included 1644 patients: 1018 premenopausal women and 626 postmenopausal women, all of whom participated in annual health examinations at Anam Hospital in Seoul, Korea, from January 2008 through December 2008. Results. On the multivariate logistic regression analysis, uric acid was identified as an independent risk factor for metabolic syndrome in both premenopausal and postmenopausal women. Uric acid levels had different relationships with blood pressure based on menopausal status, however, no such relationships with fasting glucose or age were found. Conclusions. Increased uric acid levels were associated with increased risk for metabolic syndrome in both premenopausal and postmenopausal women. In studies regarding uric acid and metabolic syndrome in women, the effects of menopausal status should be considered.

URIC acid; METABOLIC syndrome; MENOPAUSE; PERIODIC health examinations; MULTIVARIATE analysis; LOGISTIC regression analysis

Gynecological Endocrinology, 2011, Vol 27, Issue 6, p406

0951-3590

Academic Journal

10.3109/09513590.2010.493962