Works matching Proteasome inhibitors

Results: 4852

The proteasome and proteasome inhibitors in multiple myeloma.

Published in:

Cancer & Metastasis Reviews, 2017, v. 36, n. 4, p. 561, doi. 10.1007/s10555-017-9707-8

By:

Gandolfi, Sara;
Laubach, Jacob;
Hideshima, Teru;
Chauhan, Dharminder;
Anderson, Kenneth;
Richardson, Paul

Publication type:

Article

Metformin Induces Resistance of Cancer Cells to the Proteasome Inhibitor Bortezomib.

Published in:

Biomolecules (2218-273X), 2022, v. 12, n. 6, p. 756, doi. 10.3390/biom12060756

By:

Schlesser, Camille;
Meul, Thomas;
Stathopoulos, Georgios;
Meiners, Silke

Publication type:

Article

Oxidatively modified low‐density lipoproteins are potential mediators of proteasome inhibitor resistance in multiple myeloma.

Published in:

International Journal of Cancer, 2021, v. 148, n. 12, p. 3032, doi. 10.1002/ijc.33497

By:

Polusani, Srikanth R.;
Cortez, Valerie;
Esparza, Javier;
Nguyen, Huynh Nga;
Fan, Hongxin;
Velagaleti, Gopalrao V. N.;
Butler, Matthew J.;
Kinney, Marsha C.;
Oyajobi, Babatunde O.;
Habib, Samy L.;
Asmis, Reto;
Medina, Edward A.

Publication type:

Article

Proteasome inhibitors and Smac mimetics cooperate to induce cell death in diffuse large B‐cell lymphoma by stabilizing NOXA and triggering mitochondrial apoptosis.

Published in:

International Journal of Cancer, 2020, v. 147, n. 5, p. 1485, doi. 10.1002/ijc.32976

By:

Dietz, Anna;
Dalda, Nahide;
Zielke, Svenja;
Dittmann, Jessica;
Wijk, Sjoerd J.L.;
Vogler, Meike;
Fulda, Simone

Publication type:

Article

Therapeutic targeting of cancer cell cycle using proteasome inhibitors.

Published in:

Cell Division, 2012, v. 7, n. 1, p. 1, doi. 10.1186/1747-1028-7-26

By:

Rastogi, Namrata;
Mishra, Durga Prasad

Publication type:

Article

Different Strategies to Overcome Resistance to Proteasome Inhibitors—A Summary 20 Years after Their Introduction.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 16, p. 8949, doi. 10.3390/ijms25168949

By:

Tyrna, Paweł;
Procyk, Grzegorz;
Szeleszczuk, Łukasz;
Młynarczuk-Biały, Izabela

Publication type:

Article

Proteasome Inhibitors Interrupt the Activation of Non-Canonical NF-κB Signaling Pathway and Induce Cell Apoptosis in Cytarabine-Resistant HL60 Cells.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 1, p. 361, doi. 10.3390/ijms23010361

By:

Wang, Shuo-Yu;
Shih, Yin-Hwa;
Shieh, Tzong-Ming;
Tseng, Yu-Hsin

Publication type:

Article

Post-Transcriptional Regulation of Alpha One Antitrypsin by a Proteasome Inhibitor.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 12, p. 4318, doi. 10.3390/ijms21124318

By:

Rao, Lang;
Xu, Yi;
Reineke, Lucas Charles;
Bhattacharya, Abhisek;
Tyryshkin, Alexey;
Shin, Jin Na;
Eissa, N. Tony

Publication type:

Article

Disabling the Protease DDI2 Attenuates the Transcriptional Activity of NRF1 and Potentiates Proteasome Inhibitor Cytotoxicity.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 1, p. 327, doi. 10.3390/ijms21010327

By:

Northrop, Amy;
Vangala, Janakiram R.;
Feygin, Alex;
Radhakrishnan, Senthil K.

Publication type:

Article

The Effects of Proteasome Inhibitors on Telomerase Activity and Regulation in Multiple Myeloma Cells.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 10, p. 2509, doi. 10.3390/ijms20102509

By:

Shalem-Cohavi, Naama;
Beery, Einat;
Nordenberg, Jardena;
Rozovski, Uri;
Raanani, Pia;
Lahav, Meir;
Uziel, Orit

Publication type:

Article

Management and outcomes of proteasome inhibitor associated chalazia and blepharitis: a case series.

Published in:

2019

By:

Sklar, Bonnie A.;
Gervasio, Kalla A.;
Leng, Siyang;
Ghosh, Arnab;
Chari, Ajai;
Wu, Albert Y.

Publication type:

journal article

Comparison of antiproliferative and apoptotic effects of a novel proteasome inhibitor MLN2238 with bortezomib on K562 chronic myeloid leukemia cells.

Published in:

Immunopharmacology & Immunotoxicology, 2016, v. 38, n. 2, p. 87, doi. 10.3109/08923973.2015.1122616

By:

Engür, Selin;
Dikmen, Miriş;
Öztürk, Yusuf

Publication type:

Article

Attachment of the Oxadiazole Ring to Tetrazolecontaining Proteasome Inhibitor Increases Cell Death in ER+ Breast Cancer Cells.

Published in:

2023

By:

ÖZKAN, Hatice;
YENİGÜN, Vildan Betül;
KANIMDAN, Ebru;
ÖZKAN, Hamdi;
YETİM, Batuhan;
KOÇYİĞİT, Abdurrahim

Publication type:

Abstract

Peptidyl Aldehyde Inhibitors of Proteasome Induce Apoptosis Rapidly in Mouse Lymphoma RVC Cells1.

Published in:

Journal of Biochemistry, 1997, v. 121, n. 3, p. 542, doi. 10.1093/oxfordjournals.jbchem.a021620

By:

Tanimoto, Yutaka;
Onishi, Yoshiaki;
Hashimoto, Sadamitsu;
Kizaki, Harutoshi

Publication type:

Article

The Role of Proteasome Inhibitor MG132 in 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis in NC/Nga Mice.

Published in:

International Archives of Allergy & Immunology, 2018, v. 176, n. 2, p. 91, doi. 10.1159/000488155

By:

Ohkusu-Tsukada, Kozo;
Ito, Daiki;
Takahashi, Kimimasa

Publication type:

Article

Diminished feedback regulation of proteasome expression and resistance to proteasome inhibitors in breast cancer cells.

Published in:

Breast Cancer Research & Treatment, 2008, v. 107, n. 2, p. 267, doi. 10.1007/s10549-007-9553-4

By:

Xu, Haiming;
Ju, Donghong;
Jarois, Tiffany;
Xie, Youming

Publication type:

Article

Proteasome Inhibitors Decrease the Viability of Pulmonary Arterial Smooth Muscle Cells by Restoring Mitofusin-2 Expression under Hypoxic Conditions.

Published in:

Biomedicines, 2022, v. 10, n. 4, p. 873, doi. 10.3390/biomedicines10040873

By:

Chen, I-Chen;
Liu, Yi-Ching;
Wu, Yen-Hsien;
Lo, Shih-Hsing;
Wang, Shu-Chi;
Li, Chia-Yang;
Dai, Zen-Kong;
Hsu, Jong-Hau;
Yeh, Chung-Yu;
Tseng, Yu-Hsin

Publication type:

Article

Proteasome inhibitors in medullary thyroid carcinoma: time to restart with clinical trials?

Published in:

Frontiers in Endocrinology, 2023, p. 1, doi. 10.3389/fendo.2023.1145926

By:

Fanciulli, Giuseppe;
Modica, Roberta;
La Salvia, Anna;
Grossrubatscher, Erika Maria;
Florio, Tullio;
Ferraù, Francesco;
Veresani, Alessandro;
Russo, Flaminia;
Colao, Annamaria;
Faggiano, Antongiulio

Publication type:

Article

A High-Content Screening Assay for the Discovery of Novel Proteasome Inhibitors from Formosan Soft Corals.

Published in:

Marine Drugs, 2018, v. 16, n. 10, p. 395, doi. 10.3390/md16100395

By:

Ling, Xue-Hua;
Huang, Yun-Hsuan;
Huang, Min-Jay;
Duh, Chang-Yih;
Wang, Shang-Kwei

Publication type:

Article

Application of an R-group search technique in the molecular design of dipeptidyl boronic acid proteasome inhibitors.

Published in:

Journal of the Serbian Chemical Society, 2017, v. 82, n. 9, p. 1025, doi. 10.2298/JSC161227047T

By:

JIAN-BO TONG;
YUAN-YUAN LI;
GUO-YAN JIANG;
KANG-NAN LI

Publication type:

Article

Oral proteasome inhibitor with strong preclinical efficacy in myeloma models.

Published in:

2016

By:

Jonghoon Park;
Eok Park;
Cheol-Kyu Jung;
Seung-Wan Kang;
Byung Gyu Kim;
Youngjoo Jung;
Tae Hun Kim;
Ji-Young Lim;
Sung-Eun Lee;
Chang-Ki Min;
Kwang-Ai Won;
Park, Jonghoon;
Park, Eok;
Jung, Cheol-Kyu;
Kang, Seung-Wan;
Kim, Byung Gyu;
Jung, Youngjoo;
Kim, Tae Hun;
Lim, Ji-Young;
Lee, Sung-Eun

Publication type:

journal article

Tetrazolium reduction assays under-report cell death provoked by clinically relevant concentrations of proteasome inhibitors.

Published in:

Molecular Biology Reports, 2020, v. 47, n. 6, p. 4849, doi. 10.1007/s11033-020-05530-3

By:

Harris, Michael A.;
Hawkins, Christine J.;
Miles, Mark A.

Publication type:

Article

Effects of a novel proteasome inhibitor BU-32 on multiple myeloma cells.

Published in:

Cancer Chemotherapy & Pharmacology, 2014, v. 73, n. 6, p. 1263, doi. 10.1007/s00280-014-2463-3

By:

Roy, Sudipa;
Kirma, Nameer;
Santhamma, Bindu;
Tekmal, Rajeshwar;
Agyin, Joseph

Publication type:

Article

Inhibition of the PI3K/AKT signaling pathway sensitizes diffuse large B-cell lymphoma cells to treatment with proteasome inhibitors via suppression of BAG3.

Published in:

Oncology Letters, 2019, v. 17, n. 4, p. 3719

By:

Yuan, Ting;
Zhang, Feng;
Zhou, Xiangxiang;
Li, Ying;
Zhang, Ya;
Xu, Yangyang;
Wang, Xin

Publication type:

Article

Inhibition of autophagy promotes cell apoptosis induced by the proteasome inhibitor MG-132 in human esophageal squamous cell carcinoma EC9706 cells.

Published in:

Oncology Letters, 2015, v. 9, n. 5, p. 2278, doi. 10.3892/ol.2015.3047

By:

DONGLEI LIU;
MIN GAO;
YANG YANG;
YU QI;
KAI WU;
SONG ZHAO

Publication type:

Article

Proteasome inhibitor MG132 inhibits the process of renal interstitial fibrosis.

Published in:

Experimental & Therapeutic Medicine, 2019, v. 17, n. 4, p. 2953

By:

Han, Lin;
Zhu, Bingbing;
Chen, Hui;
Jin, Yuanmeng;
Liu, Jian;
Wang, Weiming

Publication type:

Article

Improving the efficacy of proteasome inhibitors in the treatment of renal cell carcinoma by combination with the human immunodeficiency virus (HIV)‐protease inhibitors lopinavir or nelfinavir.

Published in:

BJU International, 2018, v. 121, n. 4, p. 600, doi. 10.1111/bju.14083

By:

Abt, Dominik;
Besse, Andrej;
Sedlarikova, Lenka;
Kraus, Marianne;
Bader, Juergen;
Silzle, Tobias;
Vodinska, Martina;
Slaby, Ondrej;
Schmid, Hans‐Peter;
Engeler, Daniel Stephan;
Driessen, Christoph;
Besse, Lenka

Publication type:

Article

Proteasome inhibitors restore the STAT1 pathway and enhance the expression of MHC class I on human colon cancer cells.

Published in:

Journal of Biomedical Science, 2021, v. 28, n. 1, p. 1, doi. 10.1186/s12929-021-00769-9

By:

Liang, Yi-Hsin;
Chen, Kuo-Hsing;
Tsai, Jia-Huei;
Cheng, Yung-Ming;
Lee, Chang-Cheng;
Kao, Chiu-Hwa;
Chan, Kuang-Yu;
Chen, Yeh-Ting;
Hsu, Wen-Ling;
Yeh, Kun-Huei

Publication type:

Article

Role of Intracellular Calcium in Proteasome Inhibitor-Induced Endoplasmic Reticulum Stress, Autophagy, and Cell Death.

Published in:

Pharmaceutical Research, 2013, v. 30, n. 9, p. 2279, doi. 10.1007/s11095-013-1139-8

By:

Williams, Jessica;
Hou, Yifeng;
Ni, Hong-Min;
Ding, Wen-Xing

Publication type:

Article

Resistance to proteasome inhibitors and other targeted therapies in myeloma.

Published in:

British Journal of Haematology, 2018, v. 182, n. 1, p. 11, doi. 10.1111/bjh.15210

By:

Wallington‐Beddoe, Craig T.;
Sobieraj‐Teague, Magdalena;
Kuss, Bryone J.;
Pitson, Stuart M.

Publication type:

Article

Rational drug combination design in patient-derived avatars reveals effective inhibition of hepatocellular carcinoma with proteasome and CDK inhibitors.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2022, v. 41, n. 1, p. 1, doi. 10.1186/s13046-022-02436-9

By:

Lim, Jhin Jieh;
Hooi, Lissa;
Dan, Yock Young;
Bonney, Glenn K.;
Zhou, Lei;
Chow, Pierce K.-H.;
Chee, Cheng Ean;
Toh, Tan Boon;
Chow, Edward K.-H.

Publication type:

Article

Treatment with proteasome inhibitor bortezomib decreases organic anion transporting polypeptide (OATP) 1B3-mediated transport in a substrate-dependent manner.

Published in:

PLoS ONE, 2017, v. 12, n. 11, p. 1, doi. 10.1371/journal.pone.0186924

By:

Alam, Khondoker;
Farasyn, Taleah;
Crowe, Alexandra;
Ding, Kai;
Yue, Wei

Publication type:

Article

Positioning of proteasome inhibitors in therapy of solid malignancies.

Published in:

2018

By:

Roeten, Margot S. F.;
Cloos, Jacqueline;
Jansen, Gerrit

Publication type:

journal article

ZHX2 mediates proteasome inhibitor resistance via regulating nuclear translocation of NF‐κB in multiple myeloma.

Published in:

Cancer Medicine, 2020, v. 9, n. 19, p. 7244, doi. 10.1002/cam4.3347

By:

Jiang, Jifeng;
Sun, Yifeng;
Xu, Jiadai;
Xu, Tianhong;
Xu, Zhao;
Liu, Peng

Publication type:

Article

Proteasome inhibitors block intracellular growth and replication of Toxoplasma gondii.

Published in:

Parasitology, 2000, v. 121, n. 1, p. 35, doi. 10.1017/S0031182099006071

By:

SHAW, M. K.;
HE, C. Y.;
ROOS, D. S.;
TILNEY, L. G.

Publication type:

Article

Integrated transcriptomics- and structure-based drug repositioning identifies drugs with proteasome inhibitor properties.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-69465-6

By:

Larsson, Peter;
De Rosa, Maria Cristina;
Righino, Benedetta;
Olsson, Maxim;
Florea, Bogdan Iulius;
Forssell-Aronsson, Eva;
Kovács, Anikó;
Karlsson, Per;
Helou, Khalil;
Parris, Toshima Z.

Publication type:

Article

Novel copper complexes as potential proteasome inhibitors for cancer treatment (Review).

Published in:

Molecular Medicine Reports, 2017, v. 15, n. 1, p. 3, doi. 10.3892/mmr.2016.6022

By:

ZHEN ZHANG;
HUIYUN WANG;
MAOCAI YAN;
HUANNAN WANG;
CHUNYAN ZHANG

Publication type:

Article

Induction of autophagy by the MG-132 proteasome inhibitor is associated with endoplasmic reticulum stress in MCF-7 cells.

Published in:

Molecular Medicine Reports, 2016, v. 13, n. 1, p. 796, doi. 10.3892/mmr.2015.4599

By:

WENHUA BAO;
YIQI GU;
LA TA;
KEREN WANG;
ZHELI XU

Publication type:

Article

Proteasome inhibitor-induced autophagy in PC12 cells overexpressing A53T mutant α-synuclein.

Published in:

Molecular Medicine Reports, 2015, v. 11, n. 3, p. 1655, doi. 10.3892/mmr.2014.3011

By:

DANMEI LAN;
WENZHAO WANG;
JIANHUA ZHUANG;
ZHONGXIN ZHAO

Publication type:

Article

Proteasome Inhibitors Alter Levels of Intracellular Peptides in HEK293T and SH-SY5Y Cells.

Published in:

PLoS ONE, 2014, v. 9, n. 7, p. 1, doi. 10.1371/journal.pone.0103604

By:

Dasgupta, Sayani;
Castro, Leandro M.;
Dulman, Russell;
Yang, Ciyu;
Schmidt, Marion;
Ferro, Emer S.;
Fricker, Lloyd D.

Publication type:

Article

Proteasome Inhibitors Diminish c-Met Expression and Induce Cell Death in Non-Small Cell Lung Cancer Cells.

Published in:

Oncology Research, 2020, v. 28, n. 5, p. 497, doi. 10.3727/096504020X15929939001042

By:

Li, Yanhui;
Dong, Su;
Tamaskar, Arya;
Wang, Heather;
Zhao, Jing;
Ma, Haichun;
Zhao, Yutong

Publication type:

Article

Molecular Cardiotoxic Effects of Proteasome Inhibitors Carfilzomib and Ixazomib and Their Combination with Dexamethasone Involve Mitochondrial Dysregulation.

Published in:

Cardiovascular Toxicology, 2023, v. 23, n. 3/4, p. 121, doi. 10.1007/s12012-023-09785-7

By:

Jannuzzi, Ayse Tarbin;
Korkmaz, Nalan Sümeyra;
Gunaydin Akyildiz, Aysenur;
Arslan Eseryel, Sema;
Karademir Yilmaz, Betul;
Alpertunga, Buket

Publication type:

Article

Factors determining the sensitivity to proteasome inhibitors of multiple myeloma cells.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1351565

By:

Pelon, Marta;
Krzeminski, Patryk;
Tracz-Gaszewska, Zuzanna;
Misiewicz-Krzeminska, Irena

Publication type:

Article

The Proteasome Inhibitor Marizomib Evokes Endoplasmic Reticulum Stress and Promotes Apoptosis in Human Glioblastoma Cells.

Published in:

Pharmaceuticals (14248247), 2024, v. 17, n. 8, p. 1089, doi. 10.3390/ph17081089

By:

Kusaczuk, Magdalena;
Tyszka, Natalia;
Krętowski, Rafał;
Cechowska-Pasko, Marzanna

Publication type:

Article

Immunomodulatory Effect of Proteasome Inhibitors via the Induction of Immunogenic Cell Death in Myeloma Cells.

Published in:

Pharmaceuticals (14248247), 2023, v. 16, n. 10, p. 1367, doi. 10.3390/ph16101367

By:

Matsushita, Maiko;
Kashiwazaki, Sho;
Kamiko, Satoshi;
Kobori, Michio;
Osada, Makoto;
Kunieda, Hisako;
Hirao, Maki;
Ichikawa, Daiju;
Hattori, Yutaka

Publication type:

Article

New Scaffolds of Proteasome Inhibitors: Boosting Anticancer Potential by Exploiting the Synergy of In Silico and In Vitro Methodologies.

Published in:

Pharmaceuticals (14248247), 2023, v. 16, n. 8, p. 1096, doi. 10.3390/ph16081096

By:

Guedes, Romina A.;
Grilo, Jorge H.;
Carvalho, Andreia N.;
Fernandes, Pedro M. P.;
Ressurreição, Ana S.;
Brito, Vanessa;
Santos, Adriana O.;
Silvestre, Samuel;
Gallerani, Eleonora;
Gama, Maria João;
Gavioli, Riccardo;
Salvador, Jorge A. R.;
Guedes, Rita C.

Publication type:

Article

Clinical Use of Proteasome Inhibitors in the Treatment of Multiple Myeloma.

Published in:

Pharmaceuticals (14248247), 2015, v. 8, n. 1, p. 1, doi. 10.3390/ph8010001

By:

Merin, Noah M.;
Kelly, Kevin R.

Publication type:

Article

Expression of possible targets for new proteasome inhibitors in diffuse large B-cell lymphoma.

Published in:

European Journal of Haematology, 2017, v. 98, n. 1, p. 52, doi. 10.1111/ejh.12784

By:

Delforoush, Maryam;
Berglund, Mattias;
Edqvist, Per‐Henrik;
Sundström, Christer;
Gullbo, Joachim;
Enblad, Gunilla

Publication type:

Article

The anti-tumor effect of proteasome inhibitor MG132 for human adenoid cystic carcinoma: correlate with the emerging role of Nrf2/Keap1 signaling pathway.

Published in:

Head & Face Medicine, 2022, v. 18, n. 1, p. 1, doi. 10.1186/s13005-022-00318-1

By:

Xu, Jiazhi;
Wu, Haiwei;
Sun, Jiatong;
Gong, Zhiyuan;
Lu, Xiaoya;
Yang, Enli;
Chen, Zhanwei;
Huang, Shengyun;
Nong, Xiaolin;
Zhang, Dongsheng

Publication type:

Article

Interplay between proteasome inhibitors and NF-κB pathway in leukemia and lymphoma: a comprehensive review on challenges ahead of proteasome inhibitors.

Published in:

Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-023-01433-5

By:

Pakjoo, Mahdi;
Ahmadi, Seyed Esmaeil;
Zahedi, Mohammad;
Jaafari, Niloofar;
Khademi, Reyhane;
Amini, Ali;
Safa, Majid

Publication type:

Article