Combined Analysis of Smoking, TP53, and FGFR3 Mutations in Tunisian Patients with Invasive and Superficial High-Grade Bladder Tumors.

Ouerhani, Slah; Rouissi, Kamel; Kourda, Nadia; Marrakchi, Raja; Bougatef, Karim; Riadh Ben Slama, Mohamed; Sfaxi, Mohamed; Chebil, Mohamed; Ben Jilani, Sarra; Benammar Elgaaied, Amel

In our cohort, FGFR3 mutations were detected in 31.1% of bladder tumors and are associated with lower stage and grade. Concerning TP53, 62 mutations were found in tumors from 44 cases (48.88%) and are associated with advanced forms. The combined analysis of FGFR3 and TP53 mutations in our cohort showed an independent distribution. In addition, we have reported that FGFR3 mutations spectrum depends on the intensity of tobacco use (pack years: PY). Finally, we have found that the FGFR3wt/TP53mut genotype, which was associated with advanced bladder tumors; was overrepresented in light smokers (PY < 40) compared to nonsmoker patients ( p =.01).

SMOKING; GENETIC mutation; BLADDER cancer; URINARY organs; GENETIC research

Cancer Investigation, 2009, Vol 27, Issue 10, p998

0735-7907

Academic Journal

10.3109/07357900902849707