Title: Proton therapy and helical tomotherapy result in reduced dose deposition to the pancreas in the setting of cranio-spinal irradiation for medulloblastoma: Implications for reduced risk of diabetes mellitus in long-term survivors.
Authors: Brower, Jeffrey V.; Gans, Shae; Hartsell, William F.; Goldman, Stewart; Fangusaro, Jason R.; Patel, Neha; Lulla, Rishi R.; Smiley, Natasha Pillay; Chang, John Han-Chih; Gondi, Vinai
Abstract: The article discusses research which examines the association of cranio-spinal irradiation (CSI) for medulloblastoma with the development of diabetes mellitus (DM) in long-term survivors. It indicates the potential of proton beam therapy (PBT) and helical tomotherapy (HT) to reduce total dose to pancreas and pancreatic tail in the setting of CSI for medulloblastoma. It reveals that patients receiving central nervous system (CNS) irradiation are at risk for the development of late effects.
Subjects: DIABETES prevention; ANALYSIS of variance; CANCER cells; DOSE-response relationship (Radiation); LUNGS; PANCREAS; SPIRAL computed tomography; DATA analysis software; DESCRIPTIVE statistics; PROTON therapy
Publication: Acta Oncologica, 2015, Vol 54, Issue 4, p563
ISSN: 0284-186X
Publication type: Academic Journal
DOI: 10.3109/0284186X.2014.978368

Proton therapy and helical tomotherapy result in reduced dose deposition to the pancreas in the setting of cranio-spinal irradiation for medulloblastoma: Implications for reduced risk of diabetes mellitus in long-term survivors.

Brower, Jeffrey V.; Gans, Shae; Hartsell, William F.; Goldman, Stewart; Fangusaro, Jason R.; Patel, Neha; Lulla, Rishi R.; Smiley, Natasha Pillay; Chang, John Han-Chih; Gondi, Vinai