The relationship between preeclampsia, pregnancy-induced hypertension and maternal risk of breast cancer: A meta-analysis.

Kim, Jung Sun; Kang, Eun Joo; Woo, Ok Hee; Park, Kyong Hwa; Woo, Sang Uk; Yang, Dae Sik; Kim, Ae-Ree; Lee, Jae-Bok; Kim, Yeul Hong; Kim, Jun Suk; Seo, Jae Hong

Background. It has long been recognized that some human breast cancers are hormone dependent. Preeclampsia is a syndrome of pregnancy defined by the onset of hypertension and proteinuria and characterized by dysfunction of the maternal endothelium. Many hormonal changes occur with preeclampsia, and we hypothesize that these changes may influence the risk of maternal breast cancer. We also analyzed the relation between pregnancy-induced hypertension (PIH) and maternal risk of breast cancer. Methods. Among 13 relevant publications about preeclampsia and six relevant publications about PIH, some studies find preeclampsia associated with a lower risk of breast cancer, but others did not. Therefore, these results are inconclusive. We conducted meta-analysis to evaluate more precisely the relationship between preeclampsia, PIH and maternal risk of breast cancer. Results. The pooled estimate of the hazard ratio (HR) associated with preeclampsia was 0.86 (95% CI 0.73-1.01), and that associated with PIH was 0.83 (0.66-1.06), both based on the random effects model. Conclusion. Some suggestive but not entirely consistent nor conclusive evidence was found on the association between the history of preeclampsia or PIH with the subsequent risk of breast cancer.

BREAST tumor risk factors; CONFIDENCE intervals; EPIDEMIOLOGY; HYPERTENSION in pregnancy; INFORMATION storage & retrieval systems; MEDICAL databases; MEDLINE; META-analysis; ONLINE information services; PREECLAMPSIA; RESEARCH funding; STATISTICAL hypothesis testing; SYSTEMATIC reviews; DATA analysis; DATA analysis software; DESCRIPTIVE statistics

Acta Oncologica, 2013, Vol 52, Issue 8, p1643

0284-186X

Academic Journal

10.3109/0284186X.2012.750033