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- Title
Raloxifene: is it really effective on mood changes in postmenopausal osteopenic women?
- Authors
Karageyim Karsidag, A Yasemin; Karsidag, Cagatay; Buyukbayrak, Esra Esim; Kars, Bulent; Pirimoglu, Meltem; Unal, Orhan; Turan, M Cem
- Abstract
Objective. To investigate the effect of raloxifene therapy on menopausal symptoms, depression and anxiety scores using Kupperman's Scale, Hamilton Depression Rating Scale (HDRS) and Beck Anxiety Rating Scale (BARS) in osteopenic postmenopausal women. Methods. This was a prospective, randomised, parallel and open labeled clinical study. One-hundred thirty-two postmenopausal osteopenic women with natural menopause enrolled into the study. One-hundred twenty-four of them completed the study. Group I patients were treated with oral raloxifene (60 mg/day), Group II patients were treated with oral calcium supplementation (1000 mg/day) for 3 months. The patient's menopausal, depressive and anxiety symptoms were assessed by using Kupperman's Scale, HDRS and BARS, before and at the end of treatment. For statistical analysis unpaired t, ANOVA, RM-ANOVA, MANCOVA, Pearson correlation tests were used. Statistical significance level was established at p < 0.05. Results. Baseline Kupperman's Scale, HDRS and BARS scores were not different among two groups. At the end of 3 months of therapy, there was improvement in menopausal symptoms, depression and anxiety scores within both groups. When we compared change of scores before and after the treatment; group I scores were better than group II scores. Conclusion. Our results suggest that raloxifene may have a positive effect on mood in osteopenic postmenopausal women.
- Subjects
RALOXIFENE; POSTMENOPAUSE; CALCIUM; ANXIETY disorders; QUANTITATIVE research; WOMEN; THERAPEUTICS
- Publication
Journal of Psychosomatic Obstetrics & Gynecology, 2010, Vol 31, Issue 4, p273
- ISSN
0167-482X
- Publication type
Academic Journal
- DOI
10.3109/0167482X.2010.524718