Works matching DE "DRUG design"

Results: 5000

IL-1 Superfamily Across 400+ Species: Therapeutic Targets and Disease Implications.

Published in:

Biology (2079-7737), 2025, v. 14, n. 5, p. 561, doi. 10.3390/biology14050561

By:

Wang, Weibin;
Li, Dawei;
Luo, Kaiyong;
Chen, Baozheng;
Hao, Tingting;
Li, Xuzhen;
Guo, Dazhong;
Dong, Yang;
Ning, Ya

Publication type:

Article

Novel Phenoxyacetic Acid (4‐Aminophenoacetic Acid) Shikonin Ester Kills KRAS Mutant Colon Cancer Cells via Targeting the Akt Allosteric Site.

Published in:

Chemical Biology & Drug Design, 2025, v. 105, n. 5, p. 1, doi. 10.1111/cbdd.70125

By:

Ma, Yudi;
Sun, Yuqian;
Tu, Qingqing;
Lin, Faxiang;
Mei, Feng;
Chen, Qingqing;
Fu, Ting;
Yang, Liu;
Lai, Xiaohui;
Yang, Minkai;
Yin, Tongming;
Lu, Guihua;
Qi, Jinliang;
Lin, Hongyan;
Wen, Zhongling;
Yang, Yonghua;
Han, Hongwei

Publication type:

Article

Design, Synthesis, Anticancer Evaluation and Molecular Docking of Pyrimidine, Pyrido[4,3-d]pyrimidine and 5,6,7,8-Tetrahydropyrido[3,4-d]pyrimidine Derivatives as Novel KRAS-G12D Inhibitors and PROTACs.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 5, p. 696, doi. 10.3390/ph18050696

By:

Yang, Hailong;
Gan, Lu;
Zhang, Huabei

Publication type:

Article

Quinoline Quest: Kynurenic Acid Strategies for Next-Generation Therapeutics via Rational Drug Design.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 5, p. 607, doi. 10.3390/ph18050607

By:

Tanaka, Masaru;
Szatmári, István;
Vécsei, László

Publication type:

Article

Integrative Genomic and in Silico Analysis Reveals Mitochondrially Encoded Cytochrome C Oxidase III (MT—CO3) Overexpression and Potential Neem-Derived Inhibitors in Breast Cancer.

Published in:

Genes, 2025, v. 16, n. 5, p. 546, doi. 10.3390/genes16050546

By:

Agboola, Oluwaseun E.;
Agboola, Samuel S.;
Oyinloye, Oluwatoyin M.;
Fadugba, Abimbola E.;
Omolayo, Esther Y.;
Ayinla, Zainab A.;
Osunsanmi, Foluso O.;
Olaiya, Oluranti E.;
Olojo, Folake O.;
Ajiboye, Basiru O.;
Oyinloye, Babatunji E.

Publication type:

Article

In Silico Approach to Design of New Multi-Targeted Inhibitors Based on Quinoline Ring with Potential Anticancer Properties.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4620, doi. 10.3390/ijms26104620

By:

Czyżnikowska, Żaneta;
Mysłek, Martyna;
Marciniak, Aleksandra;
Płaczek, Remigiusz;
Kotynia, Aleksandra;
Krzyżak, Edward

Publication type:

Article

Genomic Subtypes in Choosing Adjuvant Therapy for Breast Cancer.

Published in:

Oncology (08909091), 2013, v. 27, n. 3, p. 204

By:

Zelnak, Amelia B.;
O'regan, Ruth M.

Publication type:

Article

Announcements.

Published in:: Oncology (08909091), 2007, v. 21, n. 2, p. 160
Publication type:: Article

Using health technology assessment to assess the value of new medicines: results of a systematic review and expert consultation across eight European countries.

Published in:

2018

By:

Angelis, Aris;
Lange, Ansgar;
Kanavos, Panos

Publication type:

journal article

Why trash don't pass? pharmaceutical licensing and safety performance of drugs.

Published in:

2017

By:

Banerjee, Tannista;
Nayak, Arnab

Publication type:

journal article

Antidepresanla Birlikte Atipik Antipsikotik Ekleme Tedavisi Kullanan ve Kullanmayan Obsesif Kompulsif Bozukluk Hastalarında Metabolik Sendrom Sıklığı: Naturalistik, Tanımlayıcı Bir Ön Çalışma

Published in:: Klinik Psikofarmakoloji Bulteni, 2010, v. 20, n. 4, p. 307, doi. 10.1080/10177833.2010.11790677
Publication type:: Article

Sequencing parasite populations.

Published in:

Nature Reviews Microbiology, 2012, v. 10, n. 2, p. 85, doi. 10.1038/nrmicro2738

By:

Sanchez-Flores, Alejandro

Publication type:

Article

Viral shape-shifting: norovirus evasion of the human immune system.

Published in:

Nature Reviews Microbiology, 2010, v. 8, n. 3, p. 231, doi. 10.1038/nrmicro2296

By:

Donaldson, Eric F.;
Lindesmith, Lisa C.;
LoBue, Anna D.;
Baric, Ralph S.

Publication type:

Article

The biology and future prospects of antivirulence therapies.

Published in:

Nature Reviews Microbiology, 2008, v. 6, n. 1, p. 17, doi. 10.1038/nrmicro1818

By:

Cegelski, Lynette;
Marshall, Garland R.;
Eldridge, Gary R.;
Hultgren, Scott J.

Publication type:

Article

Protozoan parasites: Spot the difference.

Published in:

Nature Reviews Microbiology, 2004, v. 2, n. 11, p. 854, doi. 10.1038/nrmicro1033

By:

Saunders, Jane

Publication type:

Article

Antibody-based HIV-1 vaccines: recent developments and future directions.

Published in:

2007

By:

Montefiori, David;
Sattentau, Quentin;
Flores, Jorge;
Esparza, José;
Mascola, John;
Esparza, José;
Working Group convened by the Global HIV Vaccine Enterprise

Publication type:

journal article

Live, attenuated influenza A H5N1 candidate vaccines provide broad cross-protection in mice and ferrets.

Published in:

2006

By:

Suguitan Jr., Amorsolo L.;
McAuliffe, Josephine;
Mills, Kimberly L.;
Hong Jin;
Duke, Greg;
Bin Lu;
Luke, Catherine J.;
Murphy, Brian;
Swayne, David E.;
Kemble, George;
Subbarao, Kanta;
Suguitan, Amorsolo L Jr;
Jin, Hong;
Lu, Bin

Publication type:

journal article

Designing Drugs for Parasitic Diseases of the Developing World.

Published in:

PLoS Medicine, 2005, v. 2, n. 8, p. 712, doi. 10.1371/journal.pmed.0020210

By:

McKerrow, James H.

Publication type:

Article

Letter to the Editor: Acharya Prafulla Chandra Ray, Hydroxychloroquine and COVID-19.

Published in:

2020

By:

Gupta, Nikhil;
Goswami, Binita

Publication type:

Letter

DRUG DESIGN, DEVELOPMENT, AND DELIVERY: An Interdisciplinary Course on Pharmaceuticals.

Published in:

CEE: Chemical Engineering Education, 2011, v. 45, n. 1, p. 47

By:

PRAUSNITZ, MARK R.;
BOMMARIUS, ANDREAS S.

Publication type:

Article

A SIMPLIFIED MODEL OF HUMAN ALCOHOL METABOLISM.

Published in:

CEE: Chemical Engineering Education, 2011, v. 45, n. 1, p. 21

By:

YANG, ALLEN H. J.;
DIMIDUK, KATHRYN;
DANIEL, SUSAN

Publication type:

Article

The Promise of Predictive Modeling in Drug Discovery.

Published in:

Bio-IT World, 2008, v. 7, n. 7, p. 18

By:

MAY, MIKE

Publication type:

Article

Rational Decisions.

Published in:

Bio-IT World, 2004, v. 3, n. 6, p. 94

By:

Garvey, John;
Morency, Michel

Publication type:

Article

Catalytic Asymmetric Synthesis of N−N Biaryl Atropisomers.

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 2, p. 1, doi. 10.1002/chem.202303165

By:

Feng, Jia;
Liu, Ren‐Rong

Publication type:

Article

Antimalarial Agents Derived from Metal‐Amodiaquine Complexes with Activity in Multiple Stages of the Plasmodium Life Cycle.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 55, p. 1, doi. 10.1002/chem.202301642

By:

Colina‐Vegas, Legna;
da Cruz B. Silva, Mariana;
de Souza Pereira, Caroline;
Isis Barros, Ariane;
Araújo Nobrega, Joaquim;
Navarro, Maribel;
Rottmann, Matthias;
D'Alessandro, Sarah;
Basilico, Nicoletta;
Azevedo Batista, Alzir;
Moreira, Diogo R. M.

Publication type:

Article

Cover Feature: Exploration of N‐Arylation of Backbone Amides as a Novel Tool for Conformational Modification in Peptides (Chem. Eur. J. 40/2023).

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 40, p. 1, doi. 10.1002/chem.202301803

By:

Dangi, Abha;
Kiran Marelli, Udaya

Publication type:

Article

A Late-Stage Aryl C--H Olefination Strategy and Its Application Towards Global Proteome Profiling of Δ8-Tetrahydrocannabinol.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 29, p. 1, doi. 10.1002/chem.202300531

By:

Ying-Jie Lim;
Guanghui Tang;
Zi Ye;
Chong-Jing Zhang;
Jie Wu;
Yao, Shao Q.

Publication type:

Article

Atroposelective Nenitzescu Indole Synthesis.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 25, p. 1, doi. 10.1002/chem.202300279

By:

Thönnißen, Vinzenz;
Atodiresei, Iuliana L.;
Patureau, Frederic W.

Publication type:

Article

Carbotrifluoromethylations of C−C Multiple Bonds (Excluding Aryl‐ and Alkynyltrifluoromethylations).

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 19, p. 1, doi. 10.1002/chem.202203499

By:

Aradi, Klára;
Kiss, Loránd

Publication type:

Article

Frontispiece: New Opportunities for the Utilization of the Sulfoximine Group in Medicinal Chemistry from the Drug Designer's Perspective.

Published in:: Chemistry - A European Journal, 2022, v. 28, n. 56, p. 1, doi. 10.1002/chem.202285661
Publication type:: Article

Optical Modulation of Antibiotic Resistance by Photoswitchable Cystobactamids.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 54, p. 1, doi. 10.1002/chem.202201297

By:

Testolin, Giambattista;
Richter, Jana;
Ritter, Antje;
Prochnow, Hans;
Köhnke, Jesko;
Brönstrup, Mark

Publication type:

Article

Broad‐Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve‐Agent‐Inhibited Acetylcholinesterase.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 40, p. 1, doi. 10.1002/chem.202200678

By:

Lindgren, Cecilia;
Forsgren, Nina;
Hoster, Norman;
Akfur, Christine;
Artursson, Elisabet;
Edvinsson, Lotta;
Svensson, Richard;
Worek, Franz;
Ekström, Fredrik;
Linusson, Anna

Publication type:

Article

Effect of gem‐Difluorination on the Key Physicochemical Properties Relevant to Medicinal Chemistry: The Case of Functionalized Cycloalkanes.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 19, p. 1, doi. 10.1002/chem.202200331

By:

Holovach, Sergey;
Melnykov, Kostiantyn P.;
Skreminskiy, Artem;
Herasymchuk, Maksym;
Tavlui, Olha;
Aloshyn, Danylo;
Borysko, Petro;
Rozhenko, Alexander B.;
Ryabukhin, Sergey V.;
Volochnyuk, Dmitriy M.;
Grygorenko, Oleksandr O.

Publication type:

Article

Frontispiece: Polymer Nanodiscs and Their Bioanalytical Potential.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 51, p. 1, doi. 10.1002/chem.202185161

By:

Farrelly, Michelle D.;
Martin, Lisandra L.;
Thang, San H.

Publication type:

Article

Polymer Nanodiscs and Their Bioanalytical Potential.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 51, p. 12922, doi. 10.1002/chem.202101572

By:

Farrelly, Michelle D.;
Martin, Lisandra L.;
Thang, San H.

Publication type:

Article

Stable and Storable N(CF3)2 Transfer Reagents.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 42, p. 10973, doi. 10.1002/chem.202101436

By:

Schneider, Leon N.;
Tanzer Krauel, Eva‐Maria;
Deutsch, Carl;
Urbahns, Klaus;
Bischof, Tobias;
Maibom, Kristina A. M.;
Landmann, Johannes;
Keppner, Fabian;
Kerpen, Christoph;
Hailmann, Michael;
Zapf, Ludwig;
Knuplez, Tanja;
Bertermann, Rüdiger;
Ignat'ev, Nikolai V.;
Finze, Maik

Publication type:

Article

Do Sulfonamides Interact with Aromatic Rings?

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 18, p. 5721, doi. 10.1002/chem.202004732

By:

Jian, Jie;
Hammink, Roel;
McKenzie, Christine J.;
Bickelhaupt, F. Matthias;
Poater, Jordi;
Mecinović, Jasmin

Publication type:

Article

Cover Feature: In Cellulo Generation of Fluorescent Probes for Live‐Cell Imaging of Cylooxygenase‐2 (Chem. Eur. J. 10/2021).

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 10, p. 3189, doi. 10.1002/chem.202004150

By:

Kaur, Jatinder;
Bhardwaj, Atul;
Wuest, Frank

Publication type:

Article

The Role of Fluorine in Glycomimetic Drug Design.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 7, p. 2240, doi. 10.1002/chem.202003135

By:

Hevey, Rachel

Publication type:

Article

Cover Feature: Simple Synthesis of a Heterocyclophane Exhibiting Anti‐c‐Met Activity by Acting as a Hatch Blocking Access to the Active Site (Chem. Eur. J. 5/2021).

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 5, p. 1479, doi. 10.1002/chem.202004973

By:

Takimoto, Tatsuya;
Sasaki, Hideaki;
Tsue, Hirohito;
Takahashi, Hiroki;
MacKerell, Alexander D.;
Nakamura, Ayumi;
Nakano, Katsuya;
Okazaki, Eori;
Betsuyaku, Tatsuki;
Tachibana, Ryosuke;
Hioki, Kazuhito;
Yoluk, Ozge;
Jo, Sunhwan

Publication type:

Article

Frontispiece: Cyclic Peptides as Drugs for Intracellular Targets: The Next Frontier in Peptide Therapeutic Development.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 5, p. 1, doi. 10.1002/chem.202180561

By:

Buckton, Laura K.;
Rahimi, Marwa N.;
McAlpine, Shelli R.

Publication type:

Article

Simple Synthesis of a Heterocyclophane Exhibiting Anti‐c‐Met Activity by Acting as a Hatch Blocking Access to the Active Site**.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 5, p. 1648, doi. 10.1002/chem.202001382

By:

Takimoto, Tatsuya;
Sasaki, Hideaki;
Tsue, Hirohito;
Takahashi, Hiroki;
MacKerell, Alexander D.;
Nakamura, Ayumi;
Nakano, Katsuya;
Okazaki, Eori;
Betsuyaku, Tatsuki;
Tachibana, Ryosuke;
Hioki, Kazuhito;
Yoluk, Ozge;
Jo, Sunhwan

Publication type:

Article

Frontispiece: Escaping from Flatland: Stereoconvergent Synthesis of Three‐Dimensional Scaffolds via Ruthenium(II)‐Catalyzed Noyori–Ikariya Transfer Hydrogenation.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 1, p. 1, doi. 10.1002/chem.202180162

By:

Cotman, Andrej Emanuel

Publication type:

Article

Ligand Selectivity by Inserting GCGC‐Tetrads into G‐Quadruplex Structures.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 64, p. 14730, doi. 10.1002/chem.202003004

By:

Cao, Yanwei;
Yang, Luyan;
Ding, Pi;
Li, Wenjing;
Pei, Renjun

Publication type:

Article

Frontispiece: The Thioredoxin System: A Promising Target for Cancer Drug Development.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 45, p. 1, doi. 10.1002/chem.202084562

By:

Ghareeb, Hiba;
Metanis, Norman

Publication type:

Article

Frontispiece: Benzazetidines and Related Compounds: Synthesis and Potential.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 45, p. 1, doi. 10.1002/chem.202084561

By:

Salvio, Riccardo;
Placidi, Simone;
Bella, Marco

Publication type:

Article

The Thioredoxin System: A Promising Target for Cancer Drug Development.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 45, p. 10175, doi. 10.1002/chem.201905792

By:

Ghareeb, Hiba;
Metanis, Norman

Publication type:

Article

Benzazetidines and Related Compounds: Synthesis and Potential.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 45, p. 10157, doi. 10.1002/chem.201905668

By:

Salvio, Riccardo;
Placidi, Simone;
Bella, Marco

Publication type:

Article

Cover Feature: Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics (Chem. Eur. J. 32/2020).

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 32, p. 7141, doi. 10.1002/chem.202002127

By:

Elgaher, Walid A. M.;
Hamed, Mostafa M.;
Baumann, Sascha;
Herrmann, Jennifer;
Siebenbürger, Lorenz;
Krull, Jana;
Cirnski, Katarina;
Kirschning, Andreas;
Brönstrup, Mark;
Müller, Rolf;
Hartmann, Rolf W.

Publication type:

Article

Frontispiece: Designing Molecular Spanners to Throw in the Protein Networks.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 21, p. 1, doi. 10.1002/chem.202082162

By:

Serapian, Stefano A.;
Colombo, Giorgio

Publication type:

Article