Works matching DE "DARDARIN"

Results: 628

Extra-terrestrial neurosciences.

Published in:

2019

By:

Ganapathy, Krishnan

Publication type:

Editorial

Multi‐omics analysis suggests enhanced epileptogenesis in the Cornu Ammonis 3 of the pilocarpine model of mesial temporal lobe epilepsy.

Published in:

Hippocampus, 2021, v. 31, n. 2, p. 122, doi. 10.1002/hipo.23268

By:

Canto, Amanda M.;
Matos, Alexandre H. B.;
Godoi, Alexandre B.;
Vieira, André S.;
Aoyama, Beatriz B.;
Rocha, Cristiane S.;
Henning, Barbara;
Carvalho, Benilton S.;
Pascoal, Vinicius D.B.;
Veiga, Diogo F. T.;
Gilioli, Rovilson;
Cendes, Fernando;
Lopes‐Cendes, Iscia

Publication type:

Article

Correction: Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.

Published in:: Biochemical Journal, 2025, v. 482, n. 7, p. 357, doi. 10.1042/BCJ20200937_COR
Publication type:: Article

The Parkinson’s disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress.

Published in:

Biochemical Journal, 2024, v. 481, n. 4, p. 265, doi. 10.1042/BCJ20230492

By:

McCarron, Katy R.;
Elcocks, Hannah;
Mortiboys, Heather;
Urbé, Sylvie;
Clague, Michael J.

Publication type:

Article

From structure to ætiology: a new window on the biology of leucine-rich repeat kinase 2 and Parkinson's disease.

Published in:

Biochemical Journal, 2021, v. 478, n. 14, p. 2945, doi. 10.1042/BCJ20210383

By:

Herbst, Susanne;
Lewis, Patrick A.

Publication type:

Article

Revealing aperiodic aspects of solenoid proteins from sequence information.

Published in:

Bioinformatics, 2016, v. 32, n. 18, p. 2776, doi. 10.1093/bioinformatics/btw319

By:

Hrabe, Thomas;
Jaroszewski, Lukasz;
Godzik, Adam

Publication type:

Article

Effects of Calcium Ion Dyshomeostasis and Calcium Ion-Induced Excitotoxicity in Parkinson's Disease.

Published in:

Journal of Molecular Pathology, 2024, v. 5, n. 4, p. 544, doi. 10.3390/jmp5040037

By:

Nam, Daleum;
Kim, Hyejung;
Han, Sun Jung;
Son, Ilhong;
Ho, Dong Hwan

Publication type:

Article

Possible association between the lrrk2 gene and anxiety behavior: a systematic literature review.

Published in:

Journal of Neurogenetics, 2022, v. 36, n. 4, p. 98, doi. 10.1080/01677063.2022.2144293

By:

Moreira-Júnior, RE;
Souza, RM;
de Carvalho, JG;
Bergamini, JP;
Brunialti-Godard, AL

Publication type:

Article

Clinical features and progression of Parkinson's disease with LRRK2 variants: A prospective study.

Published in:

Annals of Clinical & Translational Neurology, 2025, v. 12, n. 1, p. 34, doi. 10.1002/acn3.52244

By:

Song, Tingwei;
Zhou, Xiaoxia;
Wang, Chunyu;
Wu, Heng;
Yan, Xinxiang;
Guo, Jifeng;
Tang, Beisha;
Lei, Lifang;
Xu, Qian

Publication type:

Article

LRRK2 and Parkinson's disease: from genetics to targeted therapy.

Published in:

Annals of Clinical & Translational Neurology, 2023, v. 10, n. 6, p. 850, doi. 10.1002/acn3.51776

By:

Sosero, Yuri L.;
Gan‐Or, Ziv

Publication type:

Article

F-box/ LRR-repeat protein 7 is genetically associated with Alzheimer's disease.

Published in:

Annals of Clinical & Translational Neurology, 2015, v. 2, n. 8, p. 810, doi. 10.1002/acn3.223

By:

Tosto, Giuseppe;
Fu, Hongjun;
Vardarajan, Badri N.;
Lee, Joseph H.;
Cheng, Rong;
Reyes‐Dumeyer, Dolly;
Lantigua, Rafael;
Medrano, Martin;
Jimenez‐Velazquez, Ivonne Z.;
Elkind, Mitchell S. V.;
Wright, Clinton B.;
Sacco, Ralph L.;
Pericak‐Vance, Margaret;
Farrer, Lindsay;
Rogaeva, Ekaterina;
St George‐Hyslop, Peter;
Reitz, Christiane;
Mayeux, Richard

Publication type:

Article

Genome-Wide Identification and Characterization of the LRR-RLK Gene Family in Two Vernicia Species.

Published in:

International Journal of Genomics, 2015, p. 1, doi. 10.1155/2015/823427

By:

Zhu, Huiping;
Wang, Yangdong;
Yin, Hengfu;
Gao, Ming;
Zhang, Qiyan;
Chen, Yicun

Publication type:

Article

Expression and clinical significance of SALL4 and LGR5 in patients with lung cancer.

Published in:

Oncology Letters, 2015, v. 10, n. 6, p. 3629, doi. 10.3892/ol.2015.3772

By:

GAUTAM, AJAY KUMAR;
CHANGMING WANG;
JINRONG ZENG;
JIYING WANG;
JINGYAN LU;
JIANGHONG WEI;
GUOJIN HUANG;
BIFAN MO;
MIAO LUO;
BIWEN MO

Publication type:

Article

Plasma Metabolite Signature Classifies Male LRRK2 Parkinson's Disease Patients.

Published in:

Metabolites (2218-1989), 2022, v. 12, n. 2, p. N.PAG, doi. 10.3390/metabo12020149

By:

Dong, Chen;
Honrao, Chandrashekhar;
Rodrigues, Leonardo O.;
Wolf, Josephine;
Sheehan, Keri B.;
Surface, Matthew;
Alcalay, Roy N.;
O'Day, Elizabeth M.

Publication type:

Article

Distinctive genomic signature of neural and intestinal organoids from familial Parkinson's disease patient-derived induced pluripotent stem cells.

Published in:

Neuropathology & Applied Neurobiology, 2017, v. 43, n. 7, p. 584, doi. 10.1111/nan.12396

By:

Son, M.‐Y.;
Sim, H.;
Son, Y. S.;
Jung, K. B.;
Lee, M.‐O.;
Oh, J.‐H.;
Chung, S.‐K.;
Jung, C.‐R.;
Kim, J.

Publication type:

Article

LGI1 autoantibodies associated with cerebellar degeneration.

Published in:

Neuropathology & Applied Neurobiology, 2014, v. 40, n. 5, p. 645, doi. 10.1111/nan.12132

By:

Steriade, Claude;
Day, Gregory S.;
Lee, Liesly;
Murray, Brian J.;
Fritzler, Marvin J.;
Keith, Julia

Publication type:

Article

Asporin activates coordinated invasion of scirrhous gastric cancer and cancer-associated fibroblasts.

Published in:

Oncogene, 2015, v. 34, n. 5, p. 650, doi. 10.1038/onc.2013.584

By:

Satoyoshi, R;
Kuriyama, S;
Aiba, N;
Yashiro, M;
Tanaka, M

Publication type:

Article

Identification of critical functional residues of receptor-like kinase ERECTA.

Published in:

Journal of Experimental Botany, 2017, v. 68, n. 7, p. 1507, doi. 10.1093/jxb/erx022

By:

Kosentka, Pawel Z.;
Liang Zhang;
Simon, Yonas A.;
Satpathy, Binita;
Maradiaga, Richard;
Mitoubsi, Omar;
Shpak, Elena D.

Publication type:

Article

Dynamic changes of small RNAs in rice spikelet development reveal specialized reproductive phasiRNA pathways.

Published in:

Journal of Experimental Botany, 2016, v. 67, n. 21, p. 6037, doi. 10.1093/jxb/erw361

By:

Qili Fei;
Li Yang;
Wanqi Liang;
Dabing Zhang;
Meyers, Blake C.

Publication type:

Article

Take a deep breath: peptide signalling in stomatal patterning and differentiation.

Published in:

Journal of Experimental Botany, 2013, v. 64, n. 17, p. 5243, doi. 10.1093/jxb/ert246

By:

Richardson, Lynn G. L.;
Torii, Keiko U.

Publication type:

Article

Motor subtypes and clinical characteristics in sporadic and genetic Parkinson’s disease groups: analysis of the PPMI cohort.

Published in:

Frontiers in Neurology, 2023, p. 1, doi. 10.3389/fneur.2023.1276251

By:

Eun Hye Jeong;
Jae Yong Lee;
Sun-Ku Han;
Yoo Sung Song

Publication type:

Article

LRRK2 inhibitors and their potential in the treatment of Parkinson's disease: current perspectives.

Published in:

Clinical Pharmacology, 2016, v. 8, p. 177, doi. 10.2147/CPAA.S102191

By:

Atashrazm, Farzaneh;
Dzamko, Nicolas

Publication type:

Article

Effect of a Leucine-rich Repeat Kinase 2 Variant on Motor and Non-motor Symptoms in Chinese Parkinson's Disease Patients.

Published in:

Aging & Disease, 2016, v. 7, n. 3, p. 230, doi. 10.14336/AD.2015.1026

By:

Qian Sun;
Tian Wang;
Tian-Fang Jiang;
Pei Huang;
Dun-Hui Li;
Ying Wang;
Qin Xiao;
Jun Liu;
Sheng-Di Chen

Publication type:

Article

The Evolution of Genetic Variability at the LRRK2 Locus.

Published in:

Genes, 2024, v. 15, n. 7, p. 878, doi. 10.3390/genes15070878

By:

Guenther, Dylan T.;
Follett, Jordan;
Amouri, Rim;
Sassi, Samia Ben;
Hentati, Faycel;
Farrer, Matthew J.

Publication type:

Article

Structural Insights and Development of LRRK2 Inhibitors for Parkinson's Disease in the Last Decade.

Published in:

Genes, 2022, v. 13, n. 8, p. 1426, doi. 10.3390/genes13081426

By:

Thakur, Gunjan;
Kumar, Vikas;
Lee, Keun Woo;
Won, Chungkil

Publication type:

Article

Comprehensive Genomic Analysis Reveals the Prognostic Role of LRRK2 Copy-Number Variations in Human Malignancies.

Published in:

Genes, 2020, v. 11, n. 8, p. 846, doi. 10.3390/genes11080846

By:

Lopez, Gianluca;
Lazzeri, Giulia;
Rappa, Alessandra;
Isimbaldi, Giuseppe;
Cribiù, Fulvia Milena;
Guerini-Rocco, Elena;
Ferrero, Stefano;
Vaira, Valentina;
Di Fonzo, Alessio

Publication type:

Article

Genome-Wide Analysis of LRR-RLK Gene Family in Four Gossypium Species and Expression Analysis during Cotton Development and Stress Responses.

Published in:

Genes, 2018, v. 9, n. 12, p. 592, doi. 10.3390/genes9120592

By:

Sun, Ruibin;
Wang, Shaohui;
Ma, Dan;
Liu, Chuanliang

Publication type:

Article

Inhibitory role of peroxiredoxin 2 in LRRK2 kinase activity induced cellular pathogenesis.

Published in:

Journal of Biomedical Research, 2020, v. 34, n. 2, p. 103, doi. 10.7555/JBR.33.20190090

By:

Kang Yan;
Wenfeng Zhang;
Xu Han;
Fei Chang;
Yongjian Liu

Publication type:

Article

Distinctive roles of Rac1 and Rab29 in LRRK2 mediated membrane trafficking and neurite outgrowth.

Published in:

Journal of Biomedical Research, 2018, v. 32, n. 2, p. 145, doi. 10.7555/JBR.31.20170039

By:

Min Feng;
Xin Hu;
Na Li;
Fan Hu;
Fei Chang;
Hongfei Xu;
Yongjian Liu

Publication type:

Article

Leucine-Rich Repeat Kinase 2 in Parkinson’s Disease: Updated from Pathogenesis to Potential Therapeutic Target.

Published in:

European Neurology, 2018, v. 79, n. 5/6, p. 256, doi. 10.1159/000488938

By:

Chen, Jinhua;
Chen, Ying;
Pu, Jiali

Publication type:

Article

LRRK2 phosphorylation level correlates with abnormal motor behaviour in an experimental model of levodopa-induced dyskinesias.

Published in:

Molecular Brain, 2016, v. 9, p. 1, doi. 10.1186/s13041-016-0234-2

By:

Stanic, Jennifer;
Mellone, Manuela;
Cirnaru, Maria Daniela;
Perez-Carrion, Maria;
Zianni, Elisa;
Di Luca, Monica;
Gardoni, Fabrizio;
Piccoli, Giovanni

Publication type:

Article

Regulation of LRRK2 promoter activity and gene expression by Sp1.

Published in:

Molecular Brain, 2016, v. 9, p. 1, doi. 10.1186/s13041-016-0215-5

By:

Juelu Wang;
Weihong Song

Publication type:

Article

Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21<sup>WAF1/CIP1</sup> expression.

Published in:

Molecular Brain, 2015, v. 8, n. 1, p. 1, doi. 10.1186/s13041-015-0145-7

By:

Dong Hwan Ho;
Hyejung Kim;
Jisun Kim;
Hyuna Sim;
Hyunjun Ahn;
Janghwan Kim;
Hyemyung Seo;
Kwang Chul Chung;
Bum-Joon Park;
Ilhong Son;
Wongi Seol

Publication type:

Article

MAP1B rescues LRRK2 mutant-mediated cytotoxicity.

Published in:

Molecular Brain, 2014, v. 7, n. 1, p. 1, doi. 10.1186/1756-6606-7-29

By:

Chan, Sharon L.;
Ling-Ling Chua;
Angeles, Dario C.;
Eng-King Tan

Publication type:

Article

Expression of microRNA in human retinal pigment epithelial cells following infection with Zaire ebolavirus.

Published in:

BMC Research Notes, 2019, v. 12, n. 1, p. N.PAG, doi. 10.1186/s13104-019-4671-8

By:

Oliver, Genevieve F.;
Orang, Ayla V.;
Appukuttan, Binoy;
Marri, Shashikanth;
Michael, Michael Z.;
Marsh, Glenn A.;
Smith, Justine R.

Publication type:

Article

LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia.

Published in:

PLoS ONE, 2019, v. 14, n. 1, p. 1, doi. 10.1371/journal.pone.0210248

By:

Kim, Judong;
Pajarillo, Edward;
Rizor, Asha;
Son, Deok-Soo;
Lee, Jayden;
Aschner, Michael;
Lee, Eunsook

Publication type:

Article

Designing antibodies against LRRK2-targeted tau epitopes.

Published in:

PLoS ONE, 2018, v. 13, n. 9, p. 1, doi. 10.1371/journal.pone.0204367

By:

Hamm, Matthew;
Ladd, Thomas B.;
Levites, Yona;
Golde, Todd E.;
Giasson, Benoit I.;
Lewis, Jada

Publication type:

Article

Elucidating Critical Proteinopathic Mechanisms and Potential Drug Targets in Neurodegeneration.

Published in:

Cellular & Molecular Neurobiology, 2020, v. 40, n. 3, p. 313, doi. 10.1007/s10571-019-00741-0

By:

Dar, Khalid Bashir;
Bhat, Aashiq Hussain;
Amin, Shajrul;
Reshi, Bilal Ahmad;
Zargar, Mohammad Afzal;
Masood, Akbar;
Ganie, Showkat Ahmad

Publication type:

Article

LGR5 is a Proneural Factor and is Regulated by OLIG2 in Glioma Stem-Like Cells.

Published in:

Cellular & Molecular Neurobiology, 2013, v. 33, n. 6, p. 851, doi. 10.1007/s10571-013-9951-6

By:

Mao, Xing-gang;
Song, Shao-Jun;
Xue, Xiao-yan;
Yan, Ming;
Wang, Liang;
Lin, Wei;
Guo, Geng;
Zhang, Xiang

Publication type:

Article

LRRK2 Regulates Voltage-Gated Calcium Channel Function.

Published in:

Frontiers in Molecular Neuroscience, 2016, p. 1, doi. 10.3389/fnmol.2016.00035

By:

Bedford, Cade;
Sears, Catherine;
Perez-Carrion, Maria;
Piccoli, Giovanni;
Condliffe, Steven B.;
De Vos, Kurt;
Milnerwood, Austen J.

Publication type:

Article

LRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site status.

Published in:

Frontiers in Molecular Neuroscience, 2014, v. 7, p. 1, doi. 10.3389/fnmol.2014.00054

By:

Reynolds, April;
Doggett, Elizabeth A.;
Riddle, Steve M.;
Lebakken, Connie S.;
Nichols, R. Jeremy

Publication type:

Article

LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex.

Published in:

Frontiers in Molecular Neuroscience, 2014, v. 7, p. 1, doi. 10.3389/fnmol.2014.00049

By:

Cirnaru, Maria D.;
Marte, Antonella;
Belluzzi, Elisa;
Russo, Isabella;
Gabrielli, Martina;
Longo, Francesco;
Arcuri, Ludovico;
Murru, Luca;
Bubacco, Luigi;
Matteoli, Michela;
Fedele, Ernesto;
Sala, Carlo;
Passafaro, Maria;
Morari, Michele;
Greggio, Elisa;
Onofri, Franco;
Piccoli, Giovanni

Publication type:

Article

LRRK2 Kinase Activity and Biology are Not Uniformly Predicted by its Autophosphorylation and Cellular Phosphorylation Site Status.

Published in:

Frontiers in Molecular Neuroscience, 2014, v. 7, p. 1, doi. 10.3389/fnmol.2014.00054

By:

Reynolds, April;
Doggett, Elizabeth A.;
Riddle, Steve M.;
Lebakken, Connie S.;
Nichols, R. Jeremy

Publication type:

Article

Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation.

Published in:

Frontiers in Molecular Neuroscience, 2014, v. 7, p. 1, doi. 10.3389/fnmol.2014.00032

By:

Gilsbach, Bernd K.;
Kortholt, Arjan

Publication type:

Article

In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.

Published in:

Frontiers in Molecular Neuroscience, 2014, v. 7, p. 1, doi. 10.3389/fnmol.2014.00051

By:

Vancraenenbroeck, Renée;
De Raeymaecker, Joren;
Lobbestael, Evy;
Gao, Fangye;
De Maeyer, Marc;
Voet, Arnout;
Baekelandt, Veerle;
Taymans, Jean-Marc

Publication type:

Article

Structural biology of the LRRK2 GTPase and Kinase domains: Implications for regulation.

Published in:

Frontiers in Molecular Neuroscience, 2014, v. 7, p. 1, doi. 10.3389/fnmol.2014.00032

By:

Gilsbach, Bernd K.;
Kortholt, Arjan

Publication type:

Article

Non-motor symptoms of Parkinson's disease-insights from genetics.

Published in:

Journal of Neural Transmission, 2024, v. 131, n. 11, p. 1277, doi. 10.1007/s00702-024-02833-8

By:

Jerčić, Kristina Gotovac;
Blažeković, Antonela;
Borovečki, Sabina;
Borovečki, Fran

Publication type:

Article

Genetic testing for Parkinson's disease in clinical practice.

Published in:

Journal of Neural Transmission, 2023, v. 130, n. 6, p. 777, doi. 10.1007/s00702-023-02612-x

By:

Gasser, Thomas

Publication type:

Article

CSF Nrf2 and HSPA8 in Parkinson's disease patients with and without LRRK2 gene mutations.

Published in:

Journal of Neural Transmission, 2016, v. 123, n. 3, p. 179, doi. 10.1007/s00702-015-1479-0

By:

Loeffler, David;
Smith, Lynnae;
Coffey, Mary;
Aasly, Jan;
LeWitt, Peter

Publication type:

Article

Non-motor symptoms in Chinese Parkinson's disease patients with and without LRRK2 G2385R and R1628P variants.

Published in:

Journal of Neural Transmission, 2015, v. 122, n. 5, p. 661, doi. 10.1007/s00702-014-1281-4

By:

Li, Da-Wei;
Gu, Zhuqin;
Wang, Chaodong;
Ma, Jinghong;
Tang, Bei-Sha;
Chen, Sheng-Di;
Chan, Piu

Publication type:

Article