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- Title
In vivo responses of human A375M melanoma to a σ ligand: 18F-FDG PET imaging.
- Authors
Rybczynska, Anna A; de Bruyn, Marco; Ramakrishnan, Nisha K; de Jong, Johan R; Elsinga, Philip H; Helfrich, Wijnand; Dierckx, Rudi A J O; van Waarde, Aren
- Abstract
σ-ligands can kill tumor cells. Previously we have shown that a short in vitro incubation of C6 tumor cells with σ-ligands (24 h) results in a dose-dependent increase of cellular (18)F-FDG uptake and that the magnitude of this increase is predictive of subsequent cell death. Here, we aimed to assess whether the σ-ligand rimcazole inhibits growth of A375M melanoma xenografts in nude mice and whether rimcazole treatment changes (18)F-FDG uptake in vivo.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013, Vol 54, Issue 9, p1613
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.113.122655