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- Title
Chromosomal Abnormalities in Chromosome 5 and Chromosome 8 in Iraqi Patients with Acute Myeloid Leukemia.
- Authors
Ali, Amal Mohammed; Almukhtar, Asmaa Amer; Ismail, Noor Hashim; Majeed, Ayeda M.; Thaer, Noor; Mutlak, Fatima Abd; Alrahman, Shaimaa Abdul
- Abstract
Acute myeloid leukemia (AML) is the mostly diagnosed leukemia in adults, resulting from accumulate immature blasts in the bone marrow that are replaced instead of normal blasts that cannot function like normal blood cells. AML resulting from genetic abnormalities, including multiple gene mutations and chromosomal aberrations, are found in approximately 80% of children with AML. These shown correlations between specific recurrent chromosomal abnormalities and clinical-biological characteristics and outcomes, also, novel therapies are being developed that target some of the identified genetic defects. The aim of this study was to investigate and record the role of chromosome 5 and 8 aberrations in the development of newly diagnosed and relapsed cases of AML in Iraqi patients. Chromosomal changes were studied in peripheral blood samples from 30 Iraqi patient samples diagnosed with acute myeloid leukemia and divided into 9 newly diagnosed and 13 chemotherapytreated subjects who were incomplete remission and 8 relapsed subjects. The results of the chromosomal analysis of this study revealed numerical and structural abnormalities of both chromosomes: 5 and 8 in 16 (53.33%) and 12 (40%), respectively, within a complex karyotype and high frequencies in numerical abnormalities of chromosomes for chromosome 5 and structural abnormalities for chromosome 8. Chromosomal aberrations involving chromosomes 5 and 8 are linked to AML development and prognosis, and their presence in a complex karyotype can lead to disease progression and the worst prognosis, especially for abnormalities on chromosome 5, which were detected the most frequently. Future molecular genetic tests and complete karyotype analysis should enhance AML diagnosis and treatment.
- Subjects
CHROMOSOME abnormalities; ACUTE myeloid leukemia; GENETIC mutation; KARYOTYPES; IRAQIS
- Publication
Iraqi Journal of Cancer & Medical Genetics, 2024, Vol 17, Issue 1, p65
- ISSN
2078-6123
- Publication type
Academic Journal
- DOI
10.29409/ijcmg.v17i1.356