Evaluating the level of trace elements in Iraqi women Genetics with early-stage breast cancer.

Jarallah, Shahad A.; Al-Fartusie, Falah S.; Zgeer, Dheaa Sh.

Breast cancer is one of a group of diseases in which cells in the breast tissue change and divide uncontrollably, causing these cells to clump. Invasive cancers can spread to nearby lymph nodes or other organs (metastasize). Elements are found in different forms in nature, and these elements are very necessary for the performance of the body›s various functions; Elements such as iron and zinc are essential components of enzymes where they attract or subtract molecules and facilitate their conversion to specific end products. Few elements donate or accept electrons during redox reactions. This study aimed to follow the change in the level of trace elements (TEs) and the extent to which these changes are related to the risk of breast cancer before taking chemotherapy or removing the tumor, by drawing 5 ml of venous blood from 120 women (60 patients and 60 control), the serum was separated then used to measure Zn, Cu, Fe, Mg, Cr, and whole blood (2ml) to measure Pb, Cd. In addition to studying the receiver operating characteristic curve (ROC) of these elements. Evaluation of trace elements revealed a significant increase in the levels of Fe, Cu, Pb, and Cd, in contrast to a significant decrease in the levels of Zn and Mg in breast cancer patients compared to a healthy control group. In the current study, it was found that the Cu/Zn ratio was significantly increased in serum from breast cancer patients (equal to 2.2) compared to controls (equal to 1.08); this result could be of great value in the diagnosis and evaluation of breast cancer patients, as well as a good indicator of impaired antioxidant defense in patients. In conclusion, ROC curves revealed that trace elements (Fe, Cu, Cd, Pb) can be used as a biomarker for the diagnosis of breast cancer, and further studies are needed to confirm the relationship between trace elements and breast cancer.

GENETICS of breast cancer; RECEIVER operating characteristic curves; COPPER; TRACE elements; BREAST cancer

Iraqi Journal of Cancer & Medical Genetics, 2024, Vol 17, Issue 1, p45

2078-6123

Academic Journal

10.29409/ijcmg.v17i1.353