Introduction. Depression and anxiety are common in women of childbearing age and are associated with adverse perinatal outcomes. The prevalence in Colombian population with low obstetric risk is unknown. This study seeks to determine the prevalence of depression and gestational anxiety, as well as the associated variables in women from Bucaramanga and Floridablanca (Santander). Methodology. Descriptive cross-sectional study based on a survey and the scales of Edinburgh Postnatal Depression, Zung Anxiety Self-Assessment, Family APGAR and Perceived Social Support Questionnaire. Prevalence reasons were established. Results. In 244 pregnant women with an average age of 24.8 years the prevalence of depression was 24.6%, and anxiety 25.8%. Depression is associated with a family history of depression at a prevalence rate (RP) of 2.0; presence of anxiety at RP of 22.5, and alcohol consumption at RP of 2.9. As a protective factor, it was found that the patient had two sources of income (couple and family), at RP of 0.6. Anxiety was associated with the presence of depression at RP of 13.3; the presence of psychological violence at RP of 2.3, and not having confidence in the couple, at RP of 3.4. Discussion: The study is one of the first at the local level. It allows an approach to depression and anxiety during pregnancy in a population with low obstetric risk, with findings consistent with those reported in the literature. Conclusion. Anxiety and depression are strongly associated. It is recommended to detect psychosocial morbidity.