Results
Title

Predictive value of early pregnancy uric acid levels for adverse pregnancy outcomes.

Authors

Qiaohong Lai; Xin Zhang

Abstract

Elevated serum uric acid (SUA) levels in pregnancy are linked to adverse outcomes, including preterm birth, preeclampsia, and low birth weight. To assess the predictive value of SUA levels in early pregnancy for adverse pregnancy outcomes (APOs). A cohort of 4,240 pregnant women admitted for delivery from January 2021 to December 2022 was analyzed. APOs were compared between women with hyperuricemia (HUA) (UA > 360 µmol/L) and those without HUA. Logistic regression (LR) analysis was used to identify risk factors for APOs. Among the cohort, 295 women (6.9%) had HUA. Compared to the non-HUA group, the HUA group had a higher BMI (22.45 vs. 21.34), higher rates of hypertension (6.1% vs. 3.4%), preterm birth (10.2% vs. 6.3%), and low birth weight (10.2% vs. 5.9%). Multivariate LR analysis identified elevated UA levels, BMI, diabetes, and preeclampsia as significant risk factors for APOs. The optimal UA threshold for predicting preterm birth was 253.855 µmol/L (sensitivity: 71.4%, specificity: 55.2%). Early pregnancy SUA levels are predictive of adverse pregnancy outcomes, providing a foundation for potential clinical interventions. Given the moderate sensitivity and specificity of the identified SUA threshold for predicting preterm birth, further research is warranted to refine these values and establish their clinical implications in obstetric practice.

Subjects

CHINA; RISK factors of preeclampsia; PREDICTIVE tests; RISK assessment; RESEARCH funding; BODY mass index; PREMATURE infants; LOGISTIC regression analysis; HYPERURICEMIA; PREGNANCY outcomes; PREGNANT women; DESCRIPTIVE statistics; MULTIVARIATE analysis; LOW birth weight; LONGITUDINAL method; URIC acid; PREGNANCY complications; COMPARATIVE studies; BIOMARKERS; DIABETES; SENSITIVITY & specificity (Statistics); DISEASE risk factors; DISEASE complications; PREGNANCY

Publication

African Journal of Reproductive Health, 2024, Vol 28, Issue 12, p52

ISSN

1118-4841

Publication type

Academic Journal

DOI

10.29063/ajrh2024/v28i12.6