Works matching DE "GLUCURONIDATION"

Results: 310

Investigation of phase II metabolism of 11-hydroxy-Δ-9-tetrahydrocannabinol and metabolite verification by chemical synthesis of 11-hydroxy-Δ-9-tetrahydrocannabinol-glucuronide.

Published in:

International Journal of Legal Medicine, 2020, v. 134, n. 6, p. 2105, doi. 10.1007/s00414-020-02387-w

By:

Hassenberg, Christoph;
Clausen, Florian;
Hoffmann, Grete;
Studer, Armido;
Schürenkamp, Jennifer

Publication type:

Article

Multiplex analysis of genetic polymorphisms within UGT1A9, a gene involved in phase II of Δ9-THC metabolism.

Published in:

International Journal of Legal Medicine, 2019, v. 133, n. 2, p. 365, doi. 10.1007/s00414-018-1919-0

By:

Schneider, Julia Sophie;
Gasse, Angela;
Schürenkamp, Marianne;
Sibbing, Ursula;
Banken, Sabrina;
Pfeiffer, Heidi;
Schürenkamp, Jennifer;
Vennemann, Marielle

Publication type:

Article

In silico site of metabolism prediction for human UGT-catalyzed reactions.

Published in:

Bioinformatics, 2014, v. 30, n. 3, p. 398, doi. 10.1093/bioinformatics/btt681

By:

Peng, Jianlong;
Lu, Jing;
Shen, Qiancheng;
Zheng, Mingyue;
Luo, Xiaomin;
Zhu, Weiliang;
Jiang, Hualiang;
Chen, Kaixian

Publication type:

Article

Intestinal Glucuronidation, Prior to Hepatic Glucuronidation, Plays an Important Role in the Low Circulating Levels of Calycosin.

Published in:

Separations (2297-8739), 2022, v. 9, n. 5, p. 115, doi. 10.3390/separations9050115

By:

Jiang, Haodong;
Liu, Huan;
Hu, Pei;
Chen, Shuoji;
Ye, Yaqing;
Huang, Chenggang;
Tian, Xiaoting

Publication type:

Article

Glucuronidation: driving factors and their impact on glucuronide disposition.

Published in:

Drug Metabolism Reviews, 2017, v. 49, n. 2, p. 105, doi. 10.1080/03602532.2017.1293682

By:

Yang, Guangyi;
Ge, Shufan;
Singh, Rashim;
Basu, Sumit;
Shatzer, Katherine;
Zen, Ming;
Liu, Jiong;
Tu, Yifan;
Zhang, Chenning;
Wei, Jinbao;
Shi, Jian;
Zhu, Lijun;
Liu, Zhongqiu;
Wang, Yuan;
Gao, Song;
Hu, Ming

Publication type:

Article

Comparative metabolism of tramadol and tapentadol: a toxicological perspective.

Published in:

Drug Metabolism Reviews, 2016, v. 48, n. 4, p. 577, doi. 10.1080/03602532.2016.1229788

By:

Barbosa, Joana;
Faria, Juliana;
Queirós, Odília;
Moreira, Roxana;
Carvalho, Félix;
Dinis-Oliveira, Ricardo Jorge

Publication type:

Article

Specific features of pharmacokinetics in children.

Published in:

Drug Metabolism Reviews, 2016, v. 48, n. 1, p. 70, doi. 10.3109/03602532.2015.1135941

By:

Matalová, Petra;
Urbánek, Karel;
Anzenbacher, Pavel

Publication type:

Article

Potential drug interactions associated with glycyrrhizin and glycyrrhetinic acid.

Published in:

Drug Metabolism Reviews, 2015, v. 47, n. 2, p. 229, doi. 10.3109/03602532.2015.1029634

By:

Feng, Xinchi;
Ding, Liqin;
Qiu, Feng

Publication type:

Article

Transcriptional regulation of human UDP-glucuronosyltransferase genes.

Published in:

Drug Metabolism Reviews, 2014, v. 46, n. 4, p. 421, doi. 10.3109/03602532.2014.973037

By:

Hu, Dong Gui;
Meech, Robyn;
McKinnon, Ross A.;
Mackenzie, Peter I.

Publication type:

Article

A new perspective on the importance of glycine conjugation in the metabolism of aromatic acids.

Published in:

Drug Metabolism Reviews, 2014, v. 46, n. 3, p. 343, doi. 10.3109/03602532.2014.908903

By:

Badenhorst, Christoffel Petrus Stephanus;
Erasmus, Elardus;
van der Sluis, Rencia;
Nortje, Carla;
van Dijk, Alberdina Aike

Publication type:

Article

Abstracts from the DMW/ISSX 2000 Meeting.

Published in:: 2000
Publication type:: Conference Paper/Materials

Efflux and uptake transport and gut microbial reactivation of raloxifene glucuronides.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2025, v. 136, n. 1, p. 1, doi. 10.1111/bcpt.14107

By:

Uoti, Arttu;
Kurkela, Mika;
Niemi, Mikko;
Oksanen, Timo;
Oswald, Stefan;
Puustinen, Lauri;
Kidron, Heidi;
Sjöstedt, Noora

Publication type:

Article

Drug‐drug interaction of atazanavir on UGT1A1‐mediated glucuronidation of molidustat in human.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2021, v. 128, n. 3, p. 511, doi. 10.1111/bcpt.13538

By:

Mey, Dorina;
Gerisch, Michael;
Jungmann, Natalia A.;
Kaiser, Andreas;
Yoshikawa, Kenichi;
Schulz, Simone;
Radtke, Martin;
Lentini, Silvia

Publication type:

Article

New Insights into SN‐38 Glucuronidation: Evidence for the Important Role of UDP Glucuronosyltransferase 1A9.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2018, v. 122, n. 4, p. 424, doi. 10.1111/bcpt.12929

By:

Xiao, Ling;
Zhu, Liangliang;
Li, Wenjuan;
Li, Conghu;
Cao, Yunfeng;
Ge, Guangbo;
Sun, Xiaoyu

Publication type:

Article

Human UDP-Glucuronosyltransferases 1A1, 1A3, 1A9, 2B4 and 2B7 are Inhibited by Diethylstilbestrol.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2016, v. 119, n. 5, p. 505, doi. 10.1111/bcpt.12618

By:

Zhu, Liangliang;
Xiao, Ling;
Li, Wenjuan;
Zhang, Yuan;
Han, Wenwen;
Zhu, Yu;
Ge, Guangbo;
Yang, Ling

Publication type:

Article

Enantiomer Selective Glucuronidation of the Non-Steroidal Pure Anti-Androgen Bicalutamide by Human Liver and Kidney: Role of the Human UDP-Glucuronosyltransferase ( UGT)1A9 Enzyme.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2013, v. 113, n. 2, p. 92, doi. 10.1111/bcpt.12071

By:

Grosse, Laurent;
Campeau, Anne‐Sophie;
Caron, Sarah;
Morin, Frédéric‐Alexandre;
Meunier, Kim;
Trottier, Jocelyn;
Caron, Patrick;
Verreault, Mélanie;
Barbier, Olivier

Publication type:

Article

Human UDP-glucuronosyltransferase UGT1A4 forms tertiary N-glucuronides predominately with the energetically less favored tautomer of substituted 1 H-indazole (benzpyrazole).

Published in:

Journal of Analytical Science & Technology, 2017, v. 8, n. 1, p. 1, doi. 10.1186/s40543-017-0120-2

By:

Fredenhagen, Andreas;
Eggimann, Fabian;
Kittelmann, Matthias;
Lochmann, Thomas;
Kühnöl, Jürgen

Publication type:

Article

Species Differences in Ezetimibe Glucuronidation.

Published in:

Metabolites (2218-1989), 2024, v. 14, n. 11, p. 569, doi. 10.3390/metabo14110569

By:

Emmanuel, Shalom;
Asare, Eric A.;
Du, Ting;
Xie, Huan;
Liang, Dong;
Gao, Song

Publication type:

Article

Characterization and Metabolism of Drug Products Containing the Cocaine-Like New Psychoactive Substances Indatraline and Troparil †.

Published in:

Metabolites (2218-1989), 2024, v. 14, n. 6, p. 342, doi. 10.3390/metabo14060342

By:

Manier, Sascha K.;
Mumber, Paula;
Zapp, Josef;
Eckstein, Niels;
Meyer, Markus R.

Publication type:

Article

Profiling of Urinary Glucuronidated Bile Acids across Age Groups.

Published in:

Metabolites (2218-1989), 2022, v. 12, n. 12, p. 1230, doi. 10.3390/metabo12121230

By:

Muto, Yamato;
Suzuki, Mitsuyoshi;
Kakiyama, Genta;
Sasaki, Takahiro;
Murai, Tsuyoshi;
Takei, Hajime;
Nittono, Hiroshi

Publication type:

Article

Maternal Nutrient Restriction Disrupts Gene Expression and Metabolites Associated with Urea Cycle, Steroid Synthesis, Glucose Homeostasis, and Glucuronidation in Fetal Calf Liver.

Published in:

Metabolites (2218-1989), 2022, v. 12, n. 3, p. 203, doi. 10.3390/metabo12030203

By:

Muroya, Susumu;
Zhang, Yi;
Otomaru, Kounosuke;
Oshima, Kazunaga;
Oshima, Ichiro;
Sano, Mitsue;
Roh, Sanggun;
Ojima, Koichi;
Gotoh, Takafumi

Publication type:

Article

Obstetric Obesity is Associated with Neonatal Hyperbilirubinemia with High Prevalence in Native Hawaiians and Pacific Island Women.

Published in:

Hawaii Journal of Medicine & Public Health, 2016, v. 75, n. 12, p. 373

By:

Rougée, Luc R. A.;
Miyagi, Shogo J.;
Collie, Abby C.

Publication type:

Article

Metabolite Profiling of Dihydroartemisinin in Blood of Plasmodium -Infected and Healthy Mice Using UPLC-Q-TOF-MSE.

Published in:

Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.614159

By:

Zhao, Yifan;
Sun, Peng;
Ma, Yue;
Chang, Xiaoqiang;
Chen, Xingyu;
Ji, Xin;
Bai, Yue;
Zhang, Dong;
Yang, Lan

Publication type:

Article

Detection and Characterization of the Metabolites of Ciwujianoside B in Rats Based on UPLC-Fusion Lumos Orbitrap Mass Spectrometry.

Published in:

Journal of Analytical Methods in Chemistry, 2024, v. 2024, p. 1, doi. 10.1155/2024/3187511

By:

Dong, Wan-Ru;
Gao, Xue;
Li, Chen-Xue;
Song, Yan;
Chai, Jun-Hong;
Liang, Jun

Publication type:

Article

In vitro and in vivo studies on the metabolism and pharmacokinetics of the selective gut microbial β-glucuronidase targeting compound Inh 1.

Published in:

Xenobiotica, 2024, v. 54, n. 6, p. 304, doi. 10.1080/00498254.2024.2357765

By:

Kerins, Anna;
Butler, Phil;
Riley, Rob;
Koszyczarek, Marta;
Smith, Caroline;
Cruickshank, Faye;
Madgula, Vamsi;
Naik, Nilkanth;
Redinbo, Matthew R.;
Wilson, Ian D.

Publication type:

Article

The metabolite profiling of YR-1702 injection in human plasma, urine and feces by HPLC-Q-TOF-MS/MS.

Published in:

Xenobiotica, 2023, v. 53, n. 8/9, p. 536, doi. 10.1080/00498254.2023.2272193

By:

Yuxuan Fan;
Yufeng Ni;
Minlu Cheng;
Wenjing Guo;
Huaye Gao;
WenHui Hu;
Chang Shu;
Li Ding

Publication type:

Article

Mass balance study of [14C]SHR0302, a selective and potent JAK1 inhibitor in humans.

Published in:

Xenobiotica, 2023, v. 53, n. 2, p. 69, doi. 10.1080/00498254.2023.2176267

By:

Ge, Xinyu;
Ma, Sheng;
Yan, Shu;
Wu, Yali;
Chen, Chong;
Tang, Chongzhuang;
Zhan, Yan;
Bian, Yi-cong;
Shen, Kai;
Feng, Sheng;
Gao, Xuehu;
Zhong, Dafang;
Zhang, Hua;
Miao, Li-yan;
Diao, Xing-xing

Publication type:

Article

In vitro hepatic metabolism of the natural product quebecol.

Published in:

Xenobiotica, 2023, v. 53, n. 1, p. 1, doi. 10.1080/00498254.2023.2180691

By:

Bernardes, Gabriel;
Krol, Ed S.

Publication type:

Article

Species and tissue differences in regorafenib glucuronidation.

Published in:

Xenobiotica, 2022, v. 52, n. 2, p. 129, doi. 10.1080/00498254.2022.2055507

By:

Kojima, Ayaka;
Nadai, Masayuki;
Katoh, Miki

Publication type:

Article

Species-dependent hepatic and intestinal metabolism of selective oestrogen receptor degrader LSZ102 by sulphation and glucuronidation.

Published in:

Xenobiotica, 2022, v. 52, n. 1, p. 26, doi. 10.1080/00498254.2022.2037027

By:

Pearson, David;
Jin, Yi;
Romeo, Andrea;
Birlinger, Bertrand-Luc;
Schiller, Hilmar;
Ji, Yan;
Gunduz, Mithat;
Baldoni, Daniela;
Walles, Markus

Publication type:

Article

Adenine-related compounds modulate UDP-glucuronosyltransferase (UGT) activity in mouse liver microsomes.

Published in:

Xenobiotica, 2021, v. 51, n. 11, p. 1247, doi. 10.1080/00498254.2021.2001075

By:

Nakamura, Shoji;
Yamashita, Ryohei;
Miyauchi, Yuu;
Tanaka, Yoshitaka;
Ishii, Yuji

Publication type:

Article

Main contribution of UGT1A1 and CYP2C9 in the metabolism of UR-1102, a novel agent for the treatment of gout.

Published in:

Xenobiotica, 2021, v. 51, n. 1, p. 61, doi. 10.1080/00498254.2020.1812012

By:

Yamane, Mizuki;
Igarashi, Fumihiko;
Yamauchi, Tsuyoshi;
Nakagawa, Toshito

Publication type:

Article

Genetic variants of UDP-glucuronosyltransferases 1A1, 1A6, and 1A9 in cynomolgus and rhesus macaques.

Published in:

Xenobiotica, 2021, v. 51, n. 1, p. 115, doi. 10.1080/00498254.2020.1810367

By:

Uno, Yasuhiro;
Mikami, Takahiro;
Tsukazaki, Yasuko;
Nakanishi, Yasuharu;
Murayama, Norie;
Ikushiro, Shinichi;
Tsusaki, Hideshi;
Yamazaki, Hiroshi

Publication type:

Article

Metabolism and in vitro drug–drug interaction assessment of viloxazine.

Published in:

Xenobiotica, 2020, v. 50, n. 11, p. 1285, doi. 10.1080/00498254.2020.1767319

By:

Yu, Chungping

Publication type:

Article

Inhibition of UDP-glucuronosyltransferases by different furoquinoline alkaloids.

Published in:

Xenobiotica, 2020, v. 50, n. 10, p. 1170, doi. 10.1080/00498254.2020.1760400

By:

Li, Yixuan;
Zhang, Weihua;
Yin, Tingting;
Wang, Ce;
Wang, Feige;
Sun, Jing;
Liu, Lina;
Zhang, Qinghuai;
Zhang, Chunze

Publication type:

Article

Metabolic profiling of coumarins by the combination of UPLC-MS-based metabolomics and multiple mass defect filter.

Published in:

Xenobiotica, 2020, v. 50, n. 9, p. 1076, doi. 10.1080/00498254.2020.1744047

By:

Xiao, Yao;
Wang, Yi-Kun;
Xiao, Xue-Rong;
Zhao, Qi;
Huang, Jian-Feng;
Zhu, Wei-Feng;
Li, Fei

Publication type:

Article

Wogonin glucuronidation in liver and intestinal microsomes of humans, monkeys, dogs, rats, and mice.

Published in:

Xenobiotica, 2020, v. 50, n. 8, p. 906, doi. 10.1080/00498254.2020.1725180

By:

Hanioka, Nobumitsu;
Isobe, Takashi;
Tanaka-Kagawa, Toshiko;
Ohkawara, Susumu

Publication type:

Article

Uridine diphosphate glucuronosyltransferase 1A1.

Published in:

Xenobiotica, 2020, v. 50, n. 1, p. 64, doi. 10.1080/00498254.2019.1617910

By:

Steventon, Glyn

Publication type:

Article

Enzymatic analysis of glucuronidation of synthetic cannabinoid 1-naphthyl 1-(4-fluorobenzyl)-1H-indole-3-carboxylate (FDU-PB-22).

Published in:

Xenobiotica, 2019, v. 49, n. 12, p. 1388, doi. 10.1080/00498254.2019.1580403

By:

Jones, Sabrina;
Yarbrough, Azure L.;
Shoeib, Amal;
Bush, John M.;
Fantegrossi, William E.;
Prather, Paul L.;
Radominska-Pandya, Anna;
Fujiwara, Ryoichi

Publication type:

Article

Comparison of the inhibition potential of parthenolide and micheliolide on various UDP-glucuronosyltransferase isoforms.

Published in:

Xenobiotica, 2019, v. 49, n. 10, p. 1158, doi. 10.1080/00498254.2018.1544383

By:

Gao, Wei-Feng;
Li, Yi-Xuan;
Zhang, Wei-Hua;
Tao, Ran;
Yin, Ting-Ting;
Wang, Yi-Jia;
Liu, Li-Na;
Fu, Zhi-Wei;
Li, Sai-Nan;
Liu, Nai-Rong;
Zhang, Heng;
Liu, Guang;
Zhao, Li-Zhong;
Zhang, Xi-Peng;
Zhang, Chun-Ze

Publication type:

Article

In vitro characterization of the glucuronidation pathways of licochalcone A mediated by human UDP-glucuronosyltransferases.

Published in:

Xenobiotica, 2019, v. 49, n. 6, p. 671, doi. 10.1080/00498254.2018.1495345

By:

Xia, Yang-Liu;
Dou, Tong-Yi;
Lv, Xia;
Ge, Guang-Bo

Publication type:

Article

Identification of UGTs and BCRP as potential pharmacokinetic determinants of the natural flavonoid alpinetin.

Published in:

Xenobiotica, 2019, v. 49, n. 3, p. 276, doi. 10.1080/00498254.2018.1440657

By:

Qi, Chunli;
Fu, Jiangnan;
Zhao, Huinan;
Xing, Huijie;
Dong, Dong;
Wu, Baojian

Publication type:

Article

Regioselectivity significantly impacts microsomal glucuronidation efficiency of R/S-6, 7-, and 8-hydroxywarfarin.

Published in:

Xenobiotica, 2019, v. 49, n. 4, p. 397, doi. 10.1080/00498254.2018.1451668

By:

Kim, So-Young;
Jones, Drew R.;
Kang, Ji-Yeon;
Yun, Chul-Ho;
Miller, Grover P.

Publication type:

Article

Metabolic characteristics of Tanshinone I in human liver microsomes and S9 subcellular fractions.

Published in:

Xenobiotica, 2019, v. 49, n. 2, p. 152, doi. 10.1080/00498254.2018.1432087

By:

Li, Yue;
Fan, Yujuan;
Su, Huizong;
Wang, Qian;
Li, Guo-Fu;
Hu, Yiyang;
Jiang, Jian;
Tan, Bo;
Qiu, Furong

Publication type:

Article

Absorption, distribution, metabolism and excretion of an isocitrate dehydrogenase-2 inhibitor enasidenib in rats and humans.

Published in:

Xenobiotica, 2019, v. 49, n. 2, p. 200, doi. 10.1080/00498254.2018.1425511

By:

Tong, Zeen;
Atsriku, Christian;
Yerramilli, Usha;
Wang, Xiaomin;
Li, Yan;
Reyes, Josephine;
Fan, Bin;
Yang, Hua;
Hoffmann, Matthew;
Surapaneni, Sekhar

Publication type:

Article

Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole.

Published in:

Xenobiotica, 2018, v. 48, n. 10, p. 1021, doi. 10.1080/00498254.2017.1373312

By:

Lin, Molly;
Ly, Justin;
Takahashi, Ryan;
Chen, John;
Deese, Alan;
Robinson, Sarah J.;
Kolesnikov, Aleksandr;
Wong, Susan;
Wang, Xiaojing;
Chang, Jae H.

Publication type:

Article

The effects of UDP-sugars, UDP and Mg2+on uridine diphosphate glucuronosyltransferase activity in human liver microsomes.

Published in:

Xenobiotica, 2018, v. 48, n. 9, p. 882, doi. 10.1080/00498254.2017.1376260

By:

Walia, Gurinder;
Smith, Alexander D.;
Riches, Zoe;
Collier, Abby C.;
Coughtrie, Michael W. H.

Publication type:

Article

In vitro inhibition of human UGT isoforms by ritonavir and cobicistat.

Published in:

Xenobiotica, 2018, v. 48, n. 8, p. 764, doi. 10.1080/00498254.2017.1370655

By:

Algeelani, Sara;
Alam, Novera;
Hossain, Md Amin;
Mikus, Gerd;
Greenblatt, David J.

Publication type:

Article

Pharmacokinetic evaluation of β-caryophyllene alcohol in rats and beagle dogs.

Published in:

Xenobiotica, 2018, v. 48, n. 8, p. 845, doi. 10.1080/00498254.2017.1367441

By:

He, Jiake;
Zhou, Sufeng;
Li, Xiaonan;
Wang, Chunfeng;
Yu, Yang;
Chen, Xijing;
Lu, Yang

Publication type:

Article

Effect of UDP-Glucuronosyltransferase (UGT) 1A Polymorphism (rs8330 and rs10929303) on Glucuronidation Status of Acetaminophen.

Published in:

Dose-Response, 2017, v. 15, n. 3, p. 1, doi. 10.1177/1559325817723731

By:

Mehboob, Huma;
Tahir, Imtiaz Mahmood;
Tahiral, Tahira;
Saleem, Sadaf;
Perveen, Sofia;
Farooqi, Aboubakker

Publication type:

Article